Dual serotoninergic projections to forebrain in the rat: Morphologically distinct 5‐HT axon terminals exhibit differential vulnerability to neurotoxic amphetamine derivatives

Journal of Comparative Neurology

Volumn 314, Issue 3, 1991, Pages 558-586

  Mamounas, Laura A ^a   Mullen, Crystal A ^a   O'hearn, Elizabeth ^a   Molliver, Mark E ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

methylenedioxyamphetamine; neurotoxicity; p chloroamphetamine; raphe nuclei; serotonin

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; CHLORAMPHETAMINE; SEROTONIN;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; DENERVATION; DOSE RESPONSE; FOREBRAIN; IMMUNOCYTOCHEMISTRY; INNERVATION; MALE; NERVE CELL; NERVE FIBER; NERVE PROJECTION; NEUROTOXICITY; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM; SUBCUTANEOUS DRUG ADMINISTRATION;

3,4-METHYLENEDIOXYAMPHETAMINE; ANIMAL; AXONS; CEREBRAL CORTEX; COMPARATIVE STUDY; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; NEUROTOXINS; ORGAN SPECIFICITY; P-CHLOROAMPHETAMINE; PROSENCEPHALON; RATS; RATS, INBRED STRAINS; REFERENCE VALUES; SEROTONIN; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026342819     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.903140312     Document Type: Article

References (102)

1. Action of psychotogenic drugs on single midbrain raphe neurons
2. Ascending monoamine neurons to the telencephalon and diencephalon
3. Direct morphologic evidence for degeneration of serotonergic axons following administration of amphetamine derivatives: dl‐p‐chloroamphetamine, d‐methamphetamine, and d‐ and l‐fenfluramine
4. The serotonin‐producing neurons of the midbrain median and dorsal raphe nuclei
5. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat
6. 3H‐paroxetine‐labeled serotonin uptake sites
7. Psychotropic amphetamines have different sites of action at serotonergic (5‐HT) synapses: A comparison of p‐chloroamphetamine (PCA) and 3,4‐methylenedioxyamphetamine (MDA) with 2,5‐dimethoxy‐4‐methyiamphetamine (DOM)
8. Unlike systemic administration of p‐chloroamphetamine, direct intracerebral injection does not produce degeneration of 5‐HT axons
9. 2 receptors and serotonergic axons in rat neocortex
10. Ion conductances affected by 5‐HT receptor subtypes in mammalian neurons
11. Fine structure of labeled axons in the cerebellar cortex and nuclei of rodents and primates after intraventricular infusions with tritiated serotonin
12. Morphological correlates for transmitter synthesis, transport, release, uptake and catabolism: A study of serotonin neurons in the nuicleus paragigantocellularis lateralis
13. Differential modulation of three separate K‐conductances in hippocampal CA1 neurons by serotonin
14. Biochemical and histological evidence that methylenedioxymethamphetamine (MDMA) is toxic to neurons in the rat brain
15. Central serotonin receptors: Effector systems, physiological roles and regulation
16. Connections of the median and dorsal raphe nuclei in the rat: Autoradiographic and degeneration study
17. Evidence for the existence of monoamine‐containing neurons in the central nervous system I. Demonstration of monoamines in cell bodies of brain neurons
18. Synaptic relationships of serotonin‐immunoreactive terminal baskets on GABA neurons in the cat auditory cortex
19. Serotonergic control of the hippocampus via local inhibitory interneurons
20. Lowering of brain serotonin level by chloroamphetamines
21. Reversible and irreversible phases of serotonin depletion by 4‐chloroamphetamine
22. Fluoxetine enantiomers as antagonists of p‐chloroamphetamine effects in rats
23. Mechanisms of effects of d‐fenfluramine on brain serotonin metabolism in rats: Uptake inhibition versus release
24. Evidence for the existence of monoamine neurons in the central nervous system IV. Distribution of monoamine nerve terminal in the central nervous system
25. The mechanism of action of fenfluramine
26. The neostriatal mosaic I Compartmental organization of projections from the striatum to the substantia nigra in the rat
27. Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways
28. MDMA: Historical perspectives
29. Subjective reports of the effects of MDMA in a clinical setting
30. Can drugs be used to enhance the psychotherapeutic process? Am
31. The use of avidin biotin peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures
32. The organization of divergent axonal projections from the midbrain raphe nuclei in the rat
33. Differential behavioral effects of lesions of the median or dorsal raphe nuclei in rats: Open field and pain‐elicited aggression
34. Differential behavioral and neurochemical effects following lesions of the dorsal or median raphe nuclei in rats
35. 3H]dopamine release from superfused rat brain slices
36. Effect of depletion of brain serotonin by repeated fenfluramine on neurochemical and anorectic effects of acute fenfluramine
37. On the serotonergic innervation of the hippocampal region: An analysis employing immunohistochemistry and retrograde fluorescent tracing in the rat brain
38. Immunohistochemical localization of serotonin nerve terminals in the lateral entorhinal cortex of the rat: Demonstration of two separate patterns of innervation from the midbrain raphe
39. The distribution and orientation of serotonin fibers in the entorhinal and other retrohippocampal areas: An immunohistochemical study with anti‐serotonin antibodies in the rat's brain
40. Long‐term biochemical and behavioral effects of p‐chloroamphetamine in the rat
41. Identification of serotonin and non serotonin‐containing neurons of the mid‐brain raphe projecting to the entorhinal area and the hippocampal formation: A combined immunohistochemical and fluorescent retrograde tracing study in the rat brain
42. The serotoninergie innervation of cerebral cortex: Different classes of axon terminals arise from dorsal and median raphe nuclei
43. The serotonin innervation of the cerebral cortex in the rat: An immunohistochemical analysis
44. Accumulation of 5‐HT in non‐terminal axons after p‐chloro‐N‐methylamphetamine without degeneration of identified 5‐HT nerve terminals
45. Evidence for dual serotonergic projections to neocortex: Axons from the dorsal and median raphe nuclei are differentially vulnerable to the neurotoxin p‐chloroamphetamine (PCA)
46. Morphologically dissimilar serotonergic axon types in rat cerebral cortex are differentially vulnerable to the neurotoxin p‐chloroamphetamine (PCA)
47. Serotonergic afferents to the fat olfactory bulb: I Origins and laminar specificity of serotonergic inputs in the adult rat
48. 1 recognition site
49. Comparative effects of p‐chlorophenylalanine, p‐chloroamphetamine and p‐chloro‐N‐methylamphetamine on rat brain norepinephrine, serotonin and 5‐hydroxyindole‐3‐acetic acid
50. (±)3,4‐methelene‐dioxymethamphetamine (MDMA) produces long‐term reductions in brain 5‐hydroxytryptamine in rats
51. Anatomic evidence for a neurotoxic effect of (±) fenfluramine upon serotonergic projections in the rat
52. Serotonergic neuronal systems: What their anatomic organization tells us about function
53. Neurotoxicity of MDMA and related compounds: Anatomic studies
54. Effects of neurotoxic amphetamines on serotonergic neurons: Immunocytochemical studies
55. Dual serotonergic projections to forebrain in the rat: Two classes of axon terminals exhibit differential vulnerabiiity to the psychotropic drugs p‐chloroamphetamine (PCA) and 3,4‐methylenedioxyamphetamine (MDA)
56. Serotoninergic innervation of the cat cerebral cortex
57. 3H]serotonin from rat brain synaptosomes
58. Systemic MDA and MDMA, psychotropic substituted amphetamines, produce serotonin neurotoxicity
59. Methyl‐ enedioxyamphelamine (MDA) and methylenedioxymetham‐phetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: Immunocytochemical evidence for neurotoxicity
60. Organization of raphe‐cortical projections in rat: A quantitative retrograde study
61. Quantitative autoradipgraphic mapping of serotonin receptors in the rat brain II. Serotonin‐2 receptors
62. Quantitative autoradiographic mapping of serotonin receptors in the rat brain I. Serotonin‐1 receptors
63. 3H]5‐hydroxytryptamine binding sites by the nouroleptic spiperone in rat brain
64. 3H]spiroperidol
65. Effects of stimulation of the raphe nuclei on muricide behavior in rats
66. Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals
67. 5‐HT receptors coupled to phosphoinositide hydrolysis
68. Long‐term effects of p‐chloroamphetamine on tryptophan hydroxylase activity and on levels of 5‐hydroxytryptamine and 5‐hydroxyindole acetic acid in brain
69. P‐Chloroamphetamine: inhibition of cerebral tryptophan hydroxylase
70. Long‐term effects of p‐chloroamphetamine and related drugs on central seretonergic mechanisms
71. On the mechanism of brain 5‐hydroxytryptamine depletion by p‐chloroamphetamine and related drugs and the specificity of their action
72. Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine
73. Acute administration of methylenedioxymethamphetamine: Comparison with the neurochemical effects of its N‐desmethyl and N‐ethyl analogs
74. Neurotoxicity of MDMA: Neurochemical effects
75. In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain
76. Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine
77. Methylenedioxymethamphetamine: A potentially neurotoxic amphetamine analogue
78. Correlation between brain levels and biochemical effects of the optical isomers of p‐chloroamphetamine
79. 2‐activated interneuron
80. Behavioral effects of selective midbrain raphe lesions in the rat
81. 3H]monoamines into synaptosomes from different regions of rat brain
82. Long‐term effects of fenfluramine on central serotonergic mechanisms
83. Cells of origin of entorhinal cortical afferents to the hippocampus and fascia dentata of the rat
84. A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N‐methylated and N‐ethylated derivatives
85. Immediate and long‐term effects of 3,4‐methylenedioxymethamphetamine on serotonin pathways in brain of rat
86. The effects of 3,4‐methylenedioxymethamphetamine (MDMA) and 3,4‐methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain
87. Direct excitation of rat spinal motoneurones by serotonin
88. Quantitative morphometric analysis of two types of serotonin‐immunoreactive nerve fibers differentially responding to p‐chlorophenylalanine treatment in the rat brain
89. Interaction of serotonin and GABA in cerebral cortex and hippocampus
90. Serotonergic innervation of GABAergic neurons in the cerebral cortex
91. Behavioral evidence for the rapid release of CNS serotonin by PCA and fenfluramine
92. Raphe unit activity in freely moving cats: Correlation with level of behavioral arousal
93. Pharmacological evidence that serotonergic stimulation of prolactin secretion is mediated via the dorsal raphe nucleus
94. Evidence that serotonergic neurons in the dorsal raphe nucleus exert a stimulatory effect on the secretion of renin but not of corticosterone
95. Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices
96. The role qf the dorsal and median raphe in the inhibition of muricide
97. Topographical distribution of dorsal and median raphe neurons projecting to motor, sensorimotor, and visual cortical areas in the rat
98. Distinct morphologic classes of serotonergic axons in primages exhibit differential vulnerability to the psychotropic drug 3,4‐methyionedioxymethamphetamine
99. 125I‐lysergic acid diethylamide binds to a novel serotonergic site on rat choroid plexus epithelial cells
100. Induced homotypic sprouting of serotonergic fibers in hippocampus II. An immunocytochemistry study