Molecular studies of chronic myelogenous leukemia using the polymerase chain reaction

Cancer

Volumn 68, Issue 11, 1991, Pages 2426-2430

  Nakamura, Kozue ^a   Miyashita, Toshiyuki ^a   Ozaki, Miwako ^a   Iwaya, Makoto ^a   Nakazawa, Shinpei ^a   Okamura, Jun ^c   Kamada, Nanao ^d   Tanaka, Kimio ^d   Kobayashi, Noboru ^b   Mizutani, Shuki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CHILDREN S HOSPITAL   (Japan)

^c NATIONAL KYUSHU CANCER CENTER   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CHROMOSOME 22; CHROMOSOME BREAKAGE; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN CELL; LEUKEMIA CELL; MALE; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SOUTHERN BLOTTING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; BLOTTING, SOUTHERN; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; EXONS; FEMALE; FUSION PROTEINS, BCR-ABL; GENE REARRANGEMENT; HUMAN; LEUKEMIA, MYELOID, CHRONIC; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; MALE; MIDDLE AGE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION, GENETIC;

EID: 0026326946     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/1097-0142(19911201)68:11<2426::AID-CNCR2820681117>3.0.CO;2-C     Document Type: Article

References (23)

1. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
2. Alternative splicing of RNAs transcribed from the human abl gene and from the bcr‐abl fused gene
3. Baltimore D. The first intron in the human c‐abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia
4. Structural organization of the bcr gene and its role in the Phl translocation
5. Fused transcript of abl and bcr genes in chronic myelogenous leukemia
6. Expression of a distinctive BCR‐ABL oncogene in Phl‐positive acute lymphocytic leukemia (ALL)
7. Unique fusion of bcr and c‐abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia
8. A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukemia
9. A novel c‐abl protein product in Philadelphia positive acute lymphoblastic leukemia
10. A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukemia
11. Alternative 5′ exons in c‐abl mRNA
12. The chronic myelocytic cell line K562 contains a break‐point in bcr and produces a chimeric bcr/c‐abl transcript
13. Primer‐directed enzymatic amplification of DNA with a thermostable DNA polymerase
14. Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia‐specific mRNA sequences amplified in vitro
15. c‐abl and bcr are rearranged in a Phl negative CML patient
16. Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c‐abl sequences in blast crisis
17. Molecular lesion in chronic granulocytic leukemia is highly conserved despite ethnic and geographical variation
18. Specific sequences among DNA fragments seperated by gel electrophoresis
19. CML patients in blast crisis have breakpoints localized to a specific region of the BCR
20. Detection of two alternative bcr/abl mRNA junction and minimal residual disease in Philadelphia chromosome positive chronic myelogenous leukemia by polymerase chain reaction
21. bcr‐abl RNA in patients with chronic myelogenous leukemia
22. Detection by enzymatic amplification of bcr‐abl mRNA in peripheral blood and bone marrow cells of patients with chronic myelogenous leukemia