Importance of orthotopic transplantation procedures in assessing the effects of transfected genes on human tumor growth and metastasis

Cancer and Metastasis Review

Volumn 10, Issue 3, 1991, Pages 201-215

  Kerbel, R S ^a   Cornil, Isabelle ^a   Theodorescu, Dan ^a  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

metastasis; oncogenes; suppressor genes; tumorigenicity

Indexed keywords

ANIMAL MODEL; GENETIC TRANSFECTION; HUMAN; METASTASIS; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; REVIEW; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT;

ANIMAL; BLADDER NEOPLASMS; GENES, RECESSIVE; GENES, TUMOR SUPPRESSOR; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; NEOPLASMS; ONCOGENES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0026326467     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/BF00050792     Document Type: Article

References (61)

1. A genetic model for colorectal carcinogenesis
2. The molecular genetics of cancer
3. Suppressors of the malignant phenotype
4. A new variant of glycoprotein CD-44 confers metastatic potential to rat carcinoma cells
5. Mouse L cells expressing prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion
6. Identification of the metastasis-associated galactoside-binding lectin as a chimeric gene product with homology to an IgE-binding protein
7. Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm 23-transfected melanoma cells
8. Identification of genes controlling metastatic behaviour
9. High efficiency gene transfer and expression in normal murine B lymphocytes
10. Considerations in the use of nude mice for cancer research
11. p 53: a frequent target for genetic abnormalities in lung cancer
12. Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis
13. Orthotopic implantation in essential for the selection, growth and metastasis of human renal cell cancer in nude mice
14. Critical factors in the biology of human cancer metastasis: Twenty-eighth G.H.A. Clowes Memorial Award lecture
15. Orthotopic implantation of primary N-[-4-Nitro-2 furyl)-2-thiazolyl} formanide-induced bladder cancer in bladder submucosa: an animal model for bladder cancer study
16. Preferential growth of mammary tumors in intact mammary fatpads
17. An animal model for colon cancer metastasis: establishment and characterization of murine cell lines with enhanced liver-metastasizing ability
18. Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice
19. Heterotransplantation of retinoblastoma into the athymic ‘nude’ mouse
20. Retinoblastoma in the eyes of nude mice: quantitative assessment of therapy
21. Novel intrapulmonary model for orthotopic propogation of human lung cancers in athymic nude mice
22. Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice
23. In vivo selection of highly metastatic cells from surgical specimens of different primary colon carcinomas implanted into nude mice
24. Metastatic potential of human colorectal carcinomas implanted into nude mice: prediction of clinical outcome in patient operated for cure
25. Enhanced tumorigenicity, melanogenesis and metastasis of a human malignant melanoma observed after subdermal implantation in nude mice
26. Over-expression of normal and mutated forms of HRAS induces orthotopic bladder invasion in a human transitional cell carcinoma
27. Development of invasive tumors in the ‘nude’ mouse after injection of cultured human melanoma cells
28. Metastases of human melanomas transplanted in ‘nude’ mice
29. Human melanoma xenografts in skin tumors
30. A model of human cancer metastasis: extensive spontaneous and artificial metastasis of a human pigmented melanoma and derived variant sublines in nude mice
31. A human melanoma line heterogeneous with respect to metastatic capacity in athymic nude mice
32. Extrapulmonary tissue-specific metastasis formation in nude mice injected with FEMX-I human melanoma cells
33. Characterization of highly invasive and spontaneously metastatic human malignant melanoma cell line
34. Malignant melanoma and central nervous system metastases: incidence, diagnosis, treatment and survival
35. Highly pigmented human melanoma variant which metastasizes widely in nude mice, including to skin and brain
36. Isolation and characterization of spontaneous wheat germ agglutinin-resistant (WGAr) human melanoma mutants displaying remarkably different metastatic profiles in nude mice
37. Characterization of a metastasis-deficient lectin resistant human melanoma mutant
38. The biologic forms of malignant melanoma
39. Human melanoma: development and progression
40. The growth dominant metastatic phenotype: cellular and molecular aspects
41. Growth factor independence in vitro of primary melanoma cells from advanced but not early or intermediate lesions
42. Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression
43. Clonal dominance of primary tumors by metastatic tumor cells: genetic analysis and biological implications
44. Identification of p 53 gene mutations in bladder cancers and urine samples
45. Characterization and quantitation of the epidermal growth factor receptor in invasive and superficial bladder tumors
46. Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma
47. The epidermal growth factor receptor and the prognosis of bladder cancer
48. A new in vitro model to study invasion and metastasis of human bladder carcinomas
49. Introduction of human chromosome 11 via microcell transfer controls tumorigenic expression of HeLa cells
50. Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18
51. Suppression of the neoplastic phenotype by replacement of the Rb gene in human cancer cells
52. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene
53. Tumorigenicity in human melanoma cells controlled by introduction of human chromosome 6
54. Introduction of normal human chromosome 11 into a Wilms tumor cell line controls its tumorigenic conversion
55. Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug persistence of small cell lung cancer cell lines
56. Disseminated human malignant melanoma in congenitally immune-deficient (bg/m/xid) mice
57. Fibroblast-mediated acceleration of human epithelial tumor growth in vivo