Novel Alkaloids from the Tropical Plant Ancistrocladus abbreviatus Inhibit Cell Killing by HIV-1 and HIV-2

Journal of Medicinal Chemistry

Volumn 34, Issue 12, 1991, Pages 3402-3405

  Manfredi, Kirk P ^a   Blunt, John W ^a   Cardellina, John H ^a   McMahon, James B ^a   Boyd, Michael R ^a   Pannell, Lewis L ^b   Cragg, Gordon M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; ANTIVIRUS AGENT; MICHELLAMINE A; MICHELLAMINE B;

ANTIVIRAL ACTIVITY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; LETTER; PHYTOCHEMISTRY; PLANT; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; CELL LINE; CYTOPATHOGENIC EFFECT, VIRAL; HIV-1; HIV-2; HUMAN; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; NAPHTHALENES;

EID: 0026321672     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00116a011     Document Type: Letter

References (8)

1. Boyd, M. R. Strategies for the Identification of New Agents for the Treatment of AIDS: A National Program to Facilitate the Discovery and Preclinical Development of New Drug Candidates for Clinical Evaluation. In AIDS Etiology, Diagnosis, Treatment and Prevention; DeVita, V. T., Jr., Heilman, S., Rosenberg, S. A., Eds.; Lippincott: Philadelphia, 1988; pp 305-319.
2. Weislow, O. S.; Kiser, R.; Fine, D. L.; Shoemaker, R. H.; Bader, J.; Boyd, M. R. New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products for AIDS-Antiviral Activity. J. Natl. Cancer Inst. 1989, 81, 577-586.
3. Bringmann, G. Naphthylisoquinoline Alkaloids. In The Alkaloids; Brossi, A., Ed.; Academic Press: New York, 1986; Vol. 29, pp 141-184.
4. Govindachari, T. R.; Tuticorin, R.; Parthasarathy, P. C.; Papagudi, C. Alkaloids of Ancistrocladaceae. Heterocycles 1977, 7, 661-684.
5. Ruangrungsi, N.; Wongpanich, V.; Tantivatana, P.; Cowe, H. J.; Cox, P. J.; Funayama, S.; Cordell, G. A. Traditional Medicinal Plants of Thailand, V. Ancistrotectorine, a New Naphthalene-Isoquinoline Alkaloid from Ancistrocladus tectorius. J. Nat. Prod. 1985, 48, 529-535 and references cited therein.
6. Gulakowski, R. J.; McMahon, J. B.; Staley, P. G.; Moran, R. A.; Boyd, M. R. A Semiautomated Multiparameter Approach for Anti-HIV Drug Screening. J. Virol. Methods 1991, 33, 87-100.
7. 2+ in Lymphocytes. J. Cell Biol. 1982, 95, 189-196.
8. McCaffrey, T. A.; Agarwal, L. A.; Weksler, B. B. A Rapid Fluorometric DNA Assay for the Measurement of Cell Density and Proliferation In Vitro. In Vitro Cell Dev. Biol. 1988, 24, 247-252.