The δ-aminolevulinate dehydratase polymorphism: Higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes

Environmental Research

Volumn 56, Issue 2, 1991, Pages 109-119

  Wetmur, James G ^a   Lehnert, G ^b   Desnick, Robert J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LEAD; PORPHOBILINOGEN SYNTHASE;

ADULT; ARTICLE; BLOOD; FEMALE; HUMAN; HUMAN EXPERIMENT; INDUSTRIAL WORKER; LEAD POISONING; MALE; NORMAL HUMAN; POLLUTION; SCHOOL CHILD; WORK ENVIRONMENT;

ALLELES; CHILD; DOUBLE-BLIND METHOD; ENVIRONMENTAL EXPOSURE; GERMANY; HUMAN; ISOENZYMES; LEAD; LEAD POISONING; MALE; METALLURGY; NEW YORK CITY; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; PHENOTYPE; POLYMORPHISM (GENETICS); PORPHOBILINOGEN SYNTHASE; PROTOPORPHYRINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TURKEY;

EID: 0026318695     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/S0013-9351(05)80001-5     Document Type: Article

References (54)

1. Purification and properties of δ-aminolevulinate dehydratase from human erythrocytes
2. Occupational chronic exposure to organic solvents. XI. Alkylbenzene exposure of varnish workers: Effects on hematopoietic system
3. δ-aminolevulinic acid dehydratase isozymes and lead toxicity
4. Effects of lead exposure on the physiology of neurons
5. δ-aminolevulinate dehydrase: A new genetic polymorphism in man
6. Longitudinal analysis of prenatal and postnatal lead exposure in early cognitive development
7. Polymorphism of delta-aminolevulinic acid dehydratase in various populations
8. Relationship between lead exposure indicators and neuropsychological performance in children
9. 2+ for enzyme activity
10. Nucleotide sequence of rat liver δ-aminolevulinic acid dehydratase cDNA
11. Cloning and sequence of mouse erythroid δ-aminolevulinate dehydratase cDNA
12. Pathophysiology of heme synthesis
13. Delta-aminolaevulinic acid is a potent agonist for GABA autoreceptors
14. Delta-aminolevulinic acid and amino acid neurotransmitters
15. Ecogenetics: Historical foundation and current status
16. Kinetics of lead following intravenous administration in man
17. Erythrocyte porphobilinogen synthase activity as an indicator of lead exposure in children
18. Effects of delta-aminolaevulinic acid on contractile activity in the isolated small intestine of the rabbit
19. Two different zinc sites in bovine 5-aminolevulinate dehydratase distinguished by extended X-ray absorption fine structure
20. Lead poisoning in inherited δ-aminolevulinic acid dehydratase deficiency
21. Acute lead poisoning in inherited porphobilinogen synthase (δ-aminolevulinic acid dehydrase) deficiency
22. New type of hepatic porphyria with porphobilinogen synthase defect and intermittent acute clinical manifestation
23. Interaction of zinc and lead on δ-aminolevulinate dehydratase
24. Porphobilinogen synthase (δ-aminolevulinic acid dehydratase) activity in human erythrocytes: Reactivation by zinc and dithiothreitol depending on influence of storage
25. 5-aminolevulinate dehydratase: Zinc-65 binding and exchange with the enzyme from human erythrocytes
26. Biochemical diagnosis of an hereditary aminolaevulinate dehydratase deficiency in a 63-year-old man
27. Reevaluation of a sensitive indicator of early lead exposure. Measurement of porphobilinogen synthase in blood
28. Porphobilinogen synthase modification with methylmethanethiosulfonate
29. The porphyrias
30. Free erythrocyte protoporphyrin and zinc protoporphyrin measurements compared as primary screening methods for detection of lead poisoning
31. Lead and human health: Background and recent findings
32. Dose-response curves for erythrocyte protoporphyrin vs blood lead: Effects of iron status
33. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes
34. Differential effects of inorganic lead and delta-aminolevulinic acid in vitro on synaptosomal gamma-aminobutyric acid release
35. δ-Aminolevulinic acid: Influences on synaptic GABA receptor binding may explain CNS symptoms of porphyria
36. Deficits in psychologic and classroom performance of children with elevated dentine lead levels
37. The long-term effects of exposure to low doses of lead in childhood
38. The genetic polymorphism of human δ-aminolevulinate dehydratase in Italy
39. Threshold for lead damage to heme biosynthesis in urban children
40. Human δ-aminolevulinate dehydratase: Chromosomal localization to 9q34 by in situ hybridization
41. Pharmacogenetics
42. Association of aminolevulinate dehydratase levels and ferrochelatase inhibition in childhood lead exposure
43. Zinc and Cadmium 5-Aminolevulinate Dehydratase. Metal-Dependent pH Profiles
44. Aminolaevulinate dehydratase porphyria in infancy. A clinical and biochemical study
45. The role of zinc with special reference to the essential thiol groups in δ-aminolevulinic acid dehydratase of bovine liver
46. Some statistical methods useful in circulation research
47. Human δ-aminolevulinate dehydratase: Nucleotide sequence of a full-length cDNA clone
48. 2) allele: Implications for molecular screening of individuals for genetic susceptibility to lead poisoning
49. Results from the European multicenter study on lead neurotoxicity in children: Implications for risk assessment
50. Neuropsychological studies in children with elevated tooth-lead concentrations. II. Extended study
51. The quaternary structure of δ-aminolevulinic acid dehydratase from bovine liver
52. Polymorphism of delta-aminolevulinic acid dehydratase in lead-exposed workers