By-passing immunization. Human antibodies from V-gene libraries displayed on phage

Journal of Molecular Biology

Volumn 222, Issue 3, 1991, Pages 581-597

  Marks, James D ^a   Hoogenboom, Hennie R ^a   Bonnert, Timothy P ^a   McCafferty, John ^c   Griffiths, Andrew D ^a   Winter, Greg ^a,b  

^a MRC CENTRE FOR PROTEIN ENGINEERING   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c MEDIMMUNE LTD   (United Kingdom)

Author keywords

combinatorial libraries; filamentous phage; human antibodies

Indexed keywords

ANTIGEN; HAPTEN;

ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; BACTERIOPHAGE; BACTERIUM; BINDING AFFINITY; DNA LIBRARY; GENE EXPRESSION; HUMAN; IMMUNOGLOBULIN GENE; NONHUMAN; PERIPHERAL LYMPHOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECOMBINANT DNA TECHNOLOGY;

AMINO ACID SEQUENCE; BACTERIOPHAGES; BASE SEQUENCE; BINDING SITES, ANTIBODY; DNA, SINGLE-STRANDED; GENE EXPRESSION REGULATION, VIRAL; GENE LIBRARY; HUMAN; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOGLOBULINS, KAPPA-CHAIN; IMMUNOGLOBULINS, LAMBDA-CHAIN; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN ENGINEERING; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T;

EID: 0026317443     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-2836(91)90498-U     Document Type: Article

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