Alkylation of N‐boc‐1,2,3,4‐tetrahydroisoquinolines in the 1‐position and its application to the synthesis of isoquinoline alkaloids

Journal of Heterocyclic Chemistry

Volumn 28, Issue 7, 1991, Pages 1769-1772

  Coppola, Gary M ^a  

^a Sandoz Pharma Ltd   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 TERT BUTOXYCARBONYL 1,2,3,4 TETRAHYDROISOQUINOLINE DERIVATIVE; ISOQUINOLINE ALKALOID; LAUDANOSINE; SALSOLIDINE; TETRAHYDROISOQUINOLINE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

EID: 0026314946     PISSN: 0022152X     EISSN: 19435193     Source Type: Journal    
DOI: 10.1002/jhet.5570280720     Document Type: Article

References (18)

1. LithiatedN-pivaloyl-tetrahydroisoquinoline?a Supernuclephile
2. Diastereoselective Hydroxyalkylation of the 1-Position of 2-Pivaloyl 1,2,3,4-tetrahydroisoquinoline via Magnesium Derivatives
3. 2-Bis (dimethylamino)phosphinoyl-1-lithio-1, 2, 3, 4-tetrahydroisoquinoline. A highly nucleophilic d1-reagent for the preparation of 1-substituted tetrahydroisoquinolines