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1
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0022508422
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Homologous Recognition of a Promoter Domain Common to the MSV LTR and the HSV tk Gene
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(1986)
Cell
, vol.44
, pp. 565-576
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Graves1
Johnson2
McKnight3
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3
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0026031601
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CCAAT-Enhancer Binding Protein: A Component of A Differentiation Switch
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of outstanding interest, A review Article on the role of C/EBP in promoting the terminal differentiation of adipocytes. Premature expression of C/EBP in adipoblasts causes A direct cessation of mitotic growth. In conjunction with three adipogenic hormones, C/EBP promotes terminal cell differentiation. The role of C/EBP in regulating the balance between cell growth and differentiation in higher Animals is discussed.
-
(1991)
Science
, vol.251
, pp. 288-292
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-
Umek1
Friedman2
McKnight3
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4
-
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0026029709
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CCAAT/ Enhancer Binding Protein Gene Promoter: Binding of Nuclear Factors Ducting Differentiation of 3T3-L1 Preadipocytes
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of interest, Isolation and characterization of the C/EBP gene promoter. The activity of the C/EBP promoter increases during pre-adipocyte differentiation, showing that C/EBP onset during adipogenesis is transctiptionally regulated. C/EBP binding on its own promoter suggests A transcriptional positive-feedback mechanism for the maintenance of the differentiated state in adipocytes.
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(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 2593-2597
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-
Christy1
Kaestner2
Geiman3
Lane4
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5
-
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0025158578
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IL-6DBP, A Nuclear Protein Involved in Interleukin-6 Signal Transduction, Defines A New Family of Leucine Zipper Proteins Related to C/EBP
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of outstanding interest, Isolation of A cDNA clone coding for IL-6DBP, a member of a family of proteins that bind to IL-6 responsive elements of several AP genes. IL-6DBP is strongly homologous to C/EBP in the region of the basic domain and in the leucine zipper sequence, and it can form heterodimers with C/EBP. IL-6DBP is induced in hepatoma cells by IL-6 through a post-translational mechanism, Acting as A mediator of the IL-6-dependent AP AP response.
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(1990)
Cell
, vol.63
, pp. 643-653
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Pou1
Mancini2
Cortese3
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6
-
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0025062982
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LAP, A Novel Member of the C/EBP Gene Family, Encodes A Liver-Enriched Transcriptional Activator Protein
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of interest, Isolation of the mouse gene encoding LAP transcriptional Activator protein. LAP shares extensive sequence homology with C/EBP and they form heterodimers. LAP transcripts accumulate in several tissues, but the protein is highly enriched only in liver, appearing to be regulated post-transcriptionally. LAP is the mouse homologue of IL-6DBP.
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(1990)
Genes Dev
, vol.4
, pp. 1541-1551
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Descombes1
Chojkier2
Lichtsteiner3
Falvey4
Schibier5
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7
-
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0025297353
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A Nuclear Factor for IL-6 Expression (NF-116) is A Member of A C/EBP Family
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of outstanding interest, Cloning of NF-IL-6, A nuclear factor that specifically binds to an IL-1-responsive element in the IL-6 gene. NF-IL-6 is the human counterpart of IL-6DBP and LAP.
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(1990)
EMBO J
, vol.9
, pp. 1897-1906
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-
Akira1
Isshiki2
Sugita3
Tanabe4
Kinoshita5
Nishio6
Nakajima7
Hirano8
Kishimoto9
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8
-
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0025630643
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Expression of the Liver-Enriched Transcriptional Activator Protein DBP Follows A Stringent Circadian Rhythm
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of outstanding interest, Demonstrates that DBP accumulates in hepatocytes of Adult rats according to A circadian rhythm. DBP is not detectable during the morning or the night. Its level raises during the Afternoon reaching A maximum at about 8 pm. This oscillation may be under the negative control of glucocorticoid hormones. The expression of the albumin gene, A putative target of DBP, follows similar cyclic variations.
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(1990)
Cell
, vol.63
, pp. 1257-1266
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Wuarin1
Schibler2
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11
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0025162338
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Ig/EBP-1: A Ubiquitously Expressed Immunoglobulin Enhancer Binding Protein that is Similar to C/EBP and Heterodimerizes with C/EBP
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(1990)
Genes Dev
, vol.4
, pp. 1404-1415
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-
Roman1
Platero2
Shuman3
Calame4
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13
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0025281219
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A Myosin-Like Dimerization Helix and An Extra-Large Homeodomain Are Essential Elements of the Tripartite DNA Binding Structure of LFB1
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of interest, Mapping of the LF-BI transcriptional activation domain and A DNA-binding domain by in vitro transcription complementation assay. A tripartite DNA-binding domain includes an XL-HD, a pseudo-pou region and an amino-terminal helix similar to part of myosin. This helical region mediates dimerization, which is required for DNA binding.
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(1990)
Cell
, vol.61
, pp. 1225-1236
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-
Nicosia1
Monaci2
Tomei3
De Francesco4
Nuzzo5
Stunnenberg6
Cortese7
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14
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0025892211
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HNF-la and HNF-lP (vHNF-1) Share Dimerization and Homeo Domains, but not Activation Domains, and Form Heterodimers In Vitro
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of interest, 6, Cloning and characterization of HNF-lβ a DNA-binding protein homologous to HNF-1 (referred to in this review as HNF-la). This protein is identical to LF-B3 and variant HNF-1. These authors describe experiments, however, in which HNF-10 does not behave As A transcriptional activator of the HNF-I-dependent fibrinogen promoter.
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(1991)
Genes Dev
, vol.5
, pp. 1042-1056
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Mendel1
Hansen2
Graves3
Coniey4
Crabtree5
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15
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0025853775
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LFB3, a Heterodimer-Forming Homeoprotein of the LFB1 Family, is Expressed in Specialized Epithelia
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of outstanding interest, Isolation of a cDNA coding for LF-B3, a new member of the LFB1/HNF-1 gene family, which is a transcriptional activator highly homologous to LF-B1 in the DNA-binding domain, And forms heterodimers with LF-B1. A major emphasis is on the expression of LF-B1 and LF-B3 in different tissues and cell lines, and it is shown that LF-B3 expression precedes that of LF-B1 during development and organogenesis. Both genes Are expressed in the epithelial component of kidney and several organs derived from the primitive intestine.
-
(1991)
EMBO J
, vol.10
, Issue.6
, pp. 1435-1443
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-
De Simone1
De Magistris2
Lazaro3
Gerstner4
Monaci5
Nicosia6
Cortese7
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16
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0025775278
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vHNF1 is A Homeoprotein that Activates Transcription and Forms Heterodimers with HNFI
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of interest, Cloning of the gene encoding variant HNFA, An HNF-1-Gke protein. Variant HNF-I is identical to LF-B3 and trans-activates the albumin promoter in cotransfection experiments. Two forms of this protein, generated by a differential splicing in the ‘spacer’ region between the homeobox and pseudo-pou domains of the DNA-binding region, Are described.
-
(1991)
EMBO J
, vol.10
, Issue.6
, pp. 1445-1457
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-
Rey-Campos1
Chouard2
Yaniv3
Cereghini4
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18
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0024556115
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Multiple Hepatocyte Enriched Nuclear Factors Function in the Regulation of Transthyretin and Alpha 1-Antitrypsin Genes
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(1989)
Mol Cell Biol
, vol.9
, pp. 1415-1425
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Costa1
Grayson2
Darnel3
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20
-
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0026083212
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Hepatocyte Nuclear Factor 3a Belongs to A Gene Family in Mammals that is Homologous to the Drosophila Homeotic Gene fork head
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of outstanding interest, Describes two Additional members of the rat HNF-3 gene family: HNF3β and HNF-3γ. HNF-3α, -3β and -3γ Are Almost identical to each other and to the Drosophila homeotic gene fork head in the DNA-binding domain. The HNF-3 family in rodents is expressed in cells that derive from the lining of the primitive gut.
-
(1991)
Genes Dev
, vol.5
, pp. 416-427
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Lai1
Prezioso2
Tao3
Chen4
Darnel5
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21
-
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0025690311
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Liver-Enriched Transcription Factor HNF-4 is A Novel Member of the Steroid Hormone Receptor Superfamily
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of interest, Isolation of A cDNA clone encoding HNF-4, A dimeric transcriptional activator belonging to the steroid hormone receptor superfamily. The possibility that HNF-4 and the genes it regulates respond to an as yet unidentified ligand is discussed.
-
(1990)
Genes Dev
, vol.4
, pp. 2353-2365
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-
Sladek1
Zhong2
Lai3
Darnel4
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23
-
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0025804452
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Regulation of the Apolipoprotein AI Gene by ARP-1, a Novel Member of the Steroid Receptor Superfamily
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(1991)
Science
, vol.251
, pp. 561-565
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Ladias1
Karathanasls2
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24
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0025811870
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The Different Tissue Transcription Patterns of Genes for HNF-1, C/EBP, HNF-3, and HNF4, Protein Factors that Govern Liver-Specific Transcription
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of interest, 9, A comparative analysis of the tissue distribution of several trans-acting factors (C/EBP, HNF-1/LF-Bl, HNF-3 and HNFA) that regulate the expression of liver-specific genes. This analysis, carried out by nuclear run-on, northern blot and DNA-binding experiments, reveals the importance of post- transcriptional mechanisms in regulating the distribution of these factors.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 3807-3811
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-
Xanthopoulos1
Prezioso2
Chen3
Sladek4
Cortese5
Darnel6
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25
-
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0025319528
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DBP, a Liver-Enriched Transcriptional Activator, is Expressed Late in Ontogeny and its Tissue Specificity is Determined Posttranscriptionally
-
(1990)
Cell
, vol.61
, pp. 279-291
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-
Mueller1
Maire2
Schbler3
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26
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0025785348
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Independent Regulation of HNF-1 Alpha and HNF-1 Beta by Retinoic Acid in F9 Teratocarcinoma Cells
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(1991)
EMBO J
, vol.10
, pp. 2231-2236
-
-
Kuo1
Mendel2
Hansen3
Crabtree4
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28
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0026089359
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Extracellular Signals that Regulate Liver Transcription Factors During Hepatic Differentiation In Vitro
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of outstanding interest, The activities of three liver-enriched transcription factors, which bind the E, G and H regions of the mouse albumin promoter, eE-TF, are regulated by different combinations of hormonally defined senrm-free medium and extracefular matrix gel. eE-TF is a C/EBP-like protein, and eH-TF is a new factor that binds the TGT-17GC sequence in several hepatic genes. The authors propose a regulatory network model to explain how the extracellular environment helps to maintain the activities of transcription factors involved in hepatocyte differentiation.
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(1991)
Mol Cell Biol
, vol.11
, pp. 773-784
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Liu1
DiPersio2
Zaret3
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29
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0025285657
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crumbs Encodes an EGF-Like Protein Expressed on Apical Membranes of Drosophila Epithelial Cells and Required for Organization of Epithelia
-
(1990)
Cell
, vol.61
, pp. 787-799
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Tepass1
Theres2
Knust3
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30
-
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0017330603
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Glycogen Deposits in the Pyloric Gland of the Ascidian Styela clava (Urochordata)
-
(1977)
Cell Tiss Res
, vol.176
, pp. 47-55
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Ermak1
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