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1
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0025205276
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Integrins and Other Cell Adhesion Molecules
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(1990)
FASEB J
, vol.4
, pp. 2868-2880
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Albelda1
Buck2
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2
-
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0025222516
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The Sensation and Regulation of Interactions with the Extracellular Environment: the Cell Biology of Lymphocyte Adhesion Receptors
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(1990)
Annu Rev Cell Biol
, vol.6
, pp. 359-402
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Springer1
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3
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0025285144
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Structural basis for mechanical transduction in the frog vestibular sensory apparatus: I. The otolithic membrane
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of outstanding interest, Structural interconnections between ECM and the cytoskeleton are shown to mediate force transmission and mechanotransduction in the vestibular sensory apparatus of the frog. This finding may have important implications for force sensation in other adherent cells.
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(1990)
Hearing Research
, vol.45
, pp. 179-190
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Kacahr1
Parakkal2
Fex3
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4
-
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0025336812
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Functional Morphology of the Telson-Uropod Stretch Receptor in the Sand Crab Emerita analoga
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of outstanding interest, Mechanical deformation of a specialized ECM is shown to be responsible for activation of sensory neurons within muscle stretch receptors in the crab. The high sensitivity of this mechanoreceptor is found to be the result of increased numbers of cell-ECM contacts. One of the only papers to analyze mechanisms for controlling mechanical signal amplification.
-
(1990)
J Comp Neurol
, vol.296
, pp. 343-358
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Wilson1
Paul2
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5
-
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0025605970
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Calcium Mobilization and Exocytosis after One Mechanical Stretch of Lung Epithelial Cells
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of outstanding interest, An impressive paper which demonstrates release of intracellular calcium stores within seconds and secretion of pulmonary surfactant within minutes following a single defined mechanical stretch of lung epithelial cells cultured on a deformable culture substratum. This is a rare study involving use of deformable culture substratum. This is a rare study involving use of deformable substrata because cell shape changes are also quantified, thereby confirming that applied mechanical strain is actually distributed to the cell and, hence, is the cause of altered function.
-
(1990)
Science
, vol.250
, pp. 1266-1269
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Wirtz1
Dobbs2
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6
-
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0025162701
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Stimulation of Adenylate Cyclase Activity in Cultured Endothelial Cells Subjected to Cyclic Stretch
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of interest, Adenylate cyclase activity is shown to be activated within minutes after adherent endothelial cells are exposed to cyclical stretch. One of a series of recent studies which find that adenylate cyclase is tightly coupled to mechanoreceptors and is, at least in part, responsible for mechanochemical transduction.
-
(1990)
J Cardiovasc Surg
, vol.31
, pp. 634-639
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Letsou1
Rosales2
Maitz3
Vogt4
Sumpio5
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8
-
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0025301697
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Effect of Static Stretching on Elastin Production by Porcine Aortic Smooth Muscle Cells
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(1990)
Matrix
, vol.10
, pp. 148-153
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Sutcliffe1
Davidson2
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9
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0025039156
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Mechanical Stress and Cellular Metabolism in Living Soft Tissue Composites
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(1990)
Biomaterials
, vol.11
, pp. 465-472
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-
Jain1
Berg2
Tandon3
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11
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0026008492
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Mechanical Loading Stimulates Cell Hypertrophy and Specific Gene Expression in Cultured Rat Cardiac Myocytes
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of outstanding interest, Mechanical stretch of a deformable culture substratum is shown to activate transcription of specific genes in adherent cardiac myocytes. Transfected reporter genes containing upstream sequences of the c-fos gene are used to identify ‘force-response elements’ within the c-fos gene promoter-enhancer. A harbinger of things to come in the field of mechanochemical transduction.
-
(1991)
J Biol Chem
, vol.266
, pp. 1265-1268
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Komuro1
Katoh2
Kaida3
Shibazaki4
Kurabayashi5
Hoh6
Takau7
Yazaki8
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12
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0025553122
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Microgravity Decreases c-fos Induction and Serum Response Element Activity
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of interest, One of the first papers in which the function of a distinct molecular entity, in this case a serum response element within the c-fos gene, is shown to be sensitive to altered gravitational force in mammalian cells.
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(1990)
J Cell Sci
, vol.97
, pp. 33-38
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De Groot1
Rijken2
Hertog3
Boonstra4
Verkleij5
De Laat6
Kruijer7
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13
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0025090570
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Shear Stress Increases Inositol Triphosphate Levels in Human Endothelial Cells
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of interest, Fluid stress is shown to stimulate inositol lipid metabolism, as measured by release of inositol 1,4,5-triphosphate, within 30 s after initiation of flow. This finding is extremely important in context of recent studies which demonstrate that the same pathway can be activated by adhesion to ECM.
-
(1990)
Biomed Biophys Res Commun
, vol.170
, pp. 281-287
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Nollert1
Eskin2
McIntire3
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17
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0025500271
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The Effect of Fluid Shear Stress Upon Cell Adhesion to Fibronectin-Treated Surfaces
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of outstanding interest, Raising the number of cell-fibronectin contacts is shown to increase cell tension in fibroblasts using fluid shear stress as a method for measuring adhesive strength. This work is important because it provides a method for relating specific mechanical parameters to changes in cell-ECM contact formation and associated alterations of cell form and function.
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(1990)
J Biomed Material Res
, vol.24
, pp. 1333-1353
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Truskey1
Pirone2
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18
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0019459687
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Fibroblast Traction as a Mechanism for Collagen Morphogenesis
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(1981)
Nature
, vol.290
, pp. 249-251
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Harris1
Stopak2
Wild3
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19
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0024385876
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Shear Stress-Induced Detachment of Human Polymorphonuclear Leukocytes from Endothelial Cell Monolayers
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(1989)
Biorheology
, vol.26
, pp. 823-834
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Gallick1
Usami2
Jan3
Chien4
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21
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0025210427
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In Defense of ‘Nonmolecular’ Cell Biology
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of interest, A passionate defense of the importance of structure and mechanics in cell biology which also includes a great deal of useful information about the mechanical properties of cells.
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(1990)
Int Rev Cytol
, vol.120
, pp. 191-241
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Albrecht-Buehler1
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22
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0024461009
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Cell Adhesion to Fibronectin and Tenascin: Quantitative Measurements of Initial Binding and Subsequent Strengthening Response
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(1989)
J Cell Biol
, vol.109
, pp. 1795-1805
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Lotz1
Burdsal2
Erickson3
McClay4
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23
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0025604539
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Mechanics of Fibroblast Locomotion: Quantitative Analysis of Forces and Motions at the Leading Lamella of Fibroblasts
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of interest, Novel methods are developed to characterized the two- and three-dimensional motions of the leading edges of locomoting fibroblasts and to measure forces that are exerted. One of the first direct measurements confirming that the leading edge of migrating cells is subject to large retractive (tensile) forces.
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(1990)
J Cell Biol
, vol.6
, pp. 2415-2526
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Felder1
Elson2
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24
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0025980387
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Stress Relaxation of Contracted Collagen Gels: Disruption of Actin Filament Bundles, Release of Cell Surface Fibronectin, and Down-Regulation of DNA Down-Regulatin of DNA and Protein Synthesis
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of outstanding interest, Clear demonstration that a mechanical change in the ECM can produce rapid and profound effects on fibroblast shape and function.
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(1991)
Exp Cell Res
, vol.193
, pp. 198-207
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Mochitate1
Pawelek2
Grinnel3
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26
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0025228778
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Expression of Extracellular Matrix Components is Regulated by Substratum
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of outstanding interest, ECM flexibility is found to be a prerequisite for basement membrane deposition, generation of epithelial polarity, and induction of tissue-specific gene expression in mammary epithelial cells. This work is important because it shows the complexity of a system in which mechanical alterations of one ECM (collagen gel) feed back to regulate the assembly of another (epithelial basement membrane).
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(1990)
J Cell Biol
, vol.110
, pp. 1405-1415
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Streuli1
Bissell2
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27
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0024493103
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Expression of the Differentiated Phenotype by Epithelial Cells In Vitro is Regulated by Both Biochemistry and Mechanics of the Substratum
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(1989)
Dev Biol
, vol.131
, pp. 281-293
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Opas1
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28
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0024315634
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Mechanochemical Switching Between Growth and Differentiation During Fibroblast Growth Factor-Stimulated Angiogenesis In Vitro: Role of Extracellular Matrix
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(1989)
J Cell Biol
, vol.109
, pp. 317-330
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Ingber1
Folkman2
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29
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0025372477
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Fibronectin Controls Capillary Endothelial Cell Growth by Modulating Cell Shape
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of outstanding interest, ECM molecules are shown to regulate cell sensitivity to soluble mitogens based on their ability to resist cell tension and support changes of cell shape. Useful techniques for controlling cell shape and tension by varying cell-ECM contact formation, and methods for separating ECM- dependent changes of cell shape from integrin clustering are also presented.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 3579-3583
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Ingber1
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30
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0025304222
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Narrow Linear Strips of Adhesive Substratum are Powerful Inducers of Both Growth and Total Focal Contact Area
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(1990)
J Cell Sci
, vol.95
, pp. 577-586
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O'Neill1
Jordan2
Riddle3
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35
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0025020148
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Temporal Relationship of F-Actin Bundle Formation, Collagen and Fibronectin Matrix Assembly, and Fibronectin Receptor Expression to Wound Contraction
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of outstanding interest, The long described process of wound contraction is translated into molecular terms. Also, a specific integrin, α5β1, is shown to mediate force transmission as well as reorganization of both tissue and cytoskeletal (F-actin) architecture.
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(1990)
J Cell Biol
, vol.110
, pp. 133-145
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Welch1
Odland2
Clark3
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37
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0025007750
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Tension as a regulator and integrator of axonal growth
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of outstanding interest, A recent up-to-date review from a group which has carried out pioneering work on the effects of cell tension, applied forces, and ECM on cytoskeletal filament assembly in nerve cells. Included are multiple citations to the authors own work from the past year which demonstrate that ECM and cytoskeletal filaments maintain a mechanical force balance and that force-induced changes in thermodynamic parameters serve to regulate microtubule polymerization.
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(1990)
Cell Motility and the Cytoskeleton
, vol.17
, pp. 6-10
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-
Heidmann1
Buxbaum2
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39
-
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0025972698
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Organization of Intestinal Epithelial Cells into Multicellular Structures Requires Laminin and Functional Actin Microfilaments
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(1991)
Exp Cell Res
, vol.192
, pp. 543-549
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-
Olson1
Pysher2
Bienkowkski3
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40
-
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0025153883
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A Role for Integrin in the Formation of Sarcomeric Cytoarchitecture
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of outstanding interest, Analysis of the mechanism of sarcomere formation using muscle cells from normal Drosophila embryos and from myospheroid mutants lacking integrin βPS. An elegant demonstration of the importance of a specific integrin for mediating force transmission across the cell surface and, thus, integrating intracellular and extracellular architecture.
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(1990)
Cell
, vol.63
, pp. 525-536
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-
Volk1
Fessler2
Fessler3
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41
-
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0025134750
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Regulation of Integrin Motility and Cytoskeletal Association in Normal and RSV-Transformed Chick Embryo Fibroblasts
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of interest, Crosslinking of β-integrins is shown to be sufficient to induce cytoskeletal associations. This work is especially novel because evidence is presented which suggests that the changes of cytoskeletal anchoring that follow integrin clustering involve microtubules as well as microfilaments.
-
(1990)
J Cell Sci
, vol.97
, pp. 307-315
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-
Horvath1
Kellie2
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42
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0025336326
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1 Integrin
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of outstanding interest, The first clear demonstration that phosphorylation of an integrin subunit is required for cytoskeletal anchoring.
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(1990)
The Journal of Cell Biology
, vol.110
, pp. 2167-2174
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Shaw1
Messier2
Mercurio3
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43
-
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0025679064
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Distinct Functions for Integrins α3β1 in Focal Adhesions and α6β4/Bullous Pemphigoid Antigen in a New Stable Anchoring Contact (SAC) of Keratinocytes: Relation to Hemidesmosomes
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of interest, A novel paper in that data are presented which suggest that forces that are applied to different integrins may be distributed to different cytoskeletal systems (intermediate filaments versus actin filaments) once inside the cell.
-
(1990)
J Cell Biol
, vol.111
, pp. 3141-3154
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Carter1
Kauer2
Gil3
Gahr4
Wayner5
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44
-
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0025895086
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Integrins ανβ3 and ανβ5 Contribute to Cell Attachments to Vitronectin but Differentially Distribute on the Cell Surface
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of interest, Two different integrins that mediate attachment to the same ECM protein are shown to differ in their ability to anchor to actin filaments within the same cell. This work is important because it suggests that only certain integrins may be able to mediate force transmission to and from the cytoskeleton.
-
(1991)
J Cell Biol
, vol.113
, pp. 919-929
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-
Wayner1
Orlando2
Cheresh3
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45
-
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0025685453
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1 in Promoting Cellular Attachment and Spreading on Fibronectin
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of interest, Functional data is presented which strongly suggests that cytoskeletal anchoring of integrin αVβ3 observed in other studies can mediate force transmission and work in concert with other integrins to support tension-dependent changes of cell shape.
-
(1990)
J Cell Biol
, vol.111
, pp. 2795-2800
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-
Charo1
Nannizzi2
Smith3
Cheresh4
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46
-
-
0025183918
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1 Integrin Loss from the Cell Surface
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of interest, A developmentally programmed loss of adhesive strength that is critical for terminal differentiation of epidermal cells is shown to result from alterations of integrin function and not from changes in the numbers of integrins expressed on the cell surface. This work demonstrates another mechanism for regulating force transmission across integrins and demonstrates the danger of only analyzing changes in gene expression or protein level in developmental studies.
-
(1990)
Cell
, vol.63
, pp. 425-435
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-
Adams1
Watt2
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47
-
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0026014052
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Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets.
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(1991)
Biochem J
, vol.273
, pp. 115-120
-
-
Willigen1
Akkerman2
-
48
-
-
0025858874
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Cell/Substratum Adhesions in RSV-Transformed Rat Fibroblasts
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src may disrupt the link between talin and vinculin rather than between talin and integrins, a finding which may have important implications for regulation of mechanical signal transmission in both normal and neoplastic cells.
-
(1991)
Exp Cell Res
, vol.193
, pp. 382-397
-
-
Nermut1
Eason2
Hirst3
Kellie4
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49
-
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0025150990
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Involvement of the Membrane Cytoskeletal Proteins and the src Gene Product in Growth Cone Adhesion and Movement
-
(1990)
Neurosci Res
, pp. 80-91
-
-
Sobue1
-
50
-
-
0025032244
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Extracellular Matrix Regulates Proliferation and Phospholipid Turnover in Glomerular Epithelial Cells
-
of interest, ECM molecules are found to control glomerular epithelial cell growth by activating phosphatidylinositol turnover, independently of growth factors. This work is important because it suggests that effects on inositol metabolism observed in response to mechanical perturbation in other studies may be mediated via alterations of cell-ECM contacts.
-
(1990)
Am J Physiol
, vol.259
, pp. F326-F337
-
-
Cybulsky1
Bonventre2
Quigg3
Wolfe4
Salant5
-
51
-
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0025972360
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2+ in Human Neutrophils: Initiation by Adherence Receptors of the Integrin Family
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of interest, Integrin-mediated adhesion generates multiple internal calcium transients in migrating neutrophils. An important finding in relation to other work which demonstrates similar effects on calcium levels in response to mechanical perturbation.
-
(1991)
J Cell Biol
, vol.112
, pp. 1249-1257
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-
Jaconi1
Theler2
Schlegel3
Appel4
Wright5
Lew6
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53
-
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84909812485
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+ Antiporter by Inducing Clustering and Immobilization of its Receptor, Independent of Cell Shape
-
of outstanding interest, in press, Physical immobilization of clustered integrin chains at the cell surface is shown to be required for sustained generation of chemical signals inside the cell. This work is critical in the present context because it implies that integrins convey different chemical signals depending on whether or not their ligands can resist cytoskeletal tension that is applied to these receptors.
-
(1991)
Proc. Natl Acad Sci USA
-
-
Schwartz1
Lechene2
Ingber3
-
54
-
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0025237471
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Signal Transduction for Chemotaxis and Haptotaxis by Matrix Molecules in Tumor Cells
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of interest, ECM molecules are shown to activate different signaling mechanisms during migration depending on whether or not they are immobilized on a rigid substratum.
-
(1990)
J Cell Biol
, vol.110
, pp. 1427-1438
-
-
Aznavoorian1
Stracke2
Krutzsch3
Schiffman4
Liotta5
-
55
-
-
0024325593
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Fibroblast Contractility and Actin Organization are Stimulated by Microtubule Inhibitors
-
(1989)
J Cell Sci
, vol.93
, pp. 255-266
-
-
Danowski1
-
57
-
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0024986794
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Specific Associations Between Tubulin and G Proteins: Participation of Cytoskeletal Elements in Cellular Signal Transduction
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i protein are shown to form a complex which can, in turn, inhibit adenylate cyclase. This finding is extremely important in the context of other studies which show that mechanical perturbation and force-induced changes of cytoskeletal organization can alter adenylate cyclase activity.
-
(1990)
The Biology and Medicine of Signal Trnasduction
, pp. 381-386
-
-
Rasenick1
Wang2
Yan3
-
58
-
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0023157142
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Modulation of Gelsolin Functions by Phosphatidylinositol 4,5-bihhosphate
-
(1987)
Nature
, vol.325
, pp. 362-364
-
-
Janmey1
Stossel2
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59
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0025308055
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2 and Inhibits its Hydrolysis by Phospholipase C
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of interest, An actin-binding protein is shown to regulate phospholipase C by binding to specific phosphoinositides. This finding could provide a molecular mechanism for coupling force-induced changes of actin filament assembly with inositol lipid metabolism.
-
(1990)
Science
, vol.247
, pp. 1575-1578
-
-
Goldschmidt-Clermont1
Machesky2
Baldassare3
Pollard4
-
60
-
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0025860227
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Presence of an SH2 Domain in the Actin-Binding Protein Tensin
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of interest, Identification of a tyrosine kinase-binding domain within an actin-binding protein, for the first time, provides a molecular mechanism for linking force-dependent changes of cytoskeletal filament assembly to protein phosphorylation cascades directly within the focal contact.
-
(1991)
Science
, vol.252
, pp. 712-715
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-
Davis1
Lu2
Lo3
Lin4
Butler5
Drucker6
Roberts7
An8
Chen9
-
61
-
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0025249229
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Direct Stimulation of Adenylate Cyclase by Mechanical Forces in S49 Mouse Lymphoma Cells During Hyposmotic Swelling
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of interest, Adenylate cyclase is shown to respond directly to mechanical forces that are transmitted through the cytoskeleton. Both actin filaments and microtubules are required for force transmission in this system.
-
(1990)
J Biol Chem
, vol.265
, pp. 6569-6675
-
-
Watson1
-
62
-
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0025037387
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Endothelial Cell Motility, Integrin Receptor Clustering and Microfilament Organization are Inhibited by Agents that Increase Intracellular cAMP
-
(1990)
Lab Invest
, vol.63
, pp. 521-531
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-
Lampugnani1
Giorgi2
Defjana3
Marschisio4
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