Neutrophil accumulation in the lung in α1-antitrypsin deficiency: Spontaneous release of leukotriene B4 by alveolar macrophages

Journal of Clinical Investigation

Volumn 88, Issue 3, 1991, Pages 891-897

  Hubbard, R C ^a   Fells, G ^a   Gadek, J ^a,c   Pacholok, S ^b   Humes, J ^b   Crystal, R G ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Pulmonary and Critical Care Division   (United States)

Author keywords

Bronchoalveolar lavage; Emphysema; Inflammation; Neutrophil elastase antiprotease

Indexed keywords

CHEMOTACTIC FACTOR; LEUKOCYTE ELASTASE; LEUKOTRIENE B4; PANCREATIC ELASTASE;

ADULT; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; FEMALE; HUMAN; IMMUNOLOGY; LEUKOCYTE COUNT; LUNG; LUNG ALVEOLUS; MACROPHAGE; MALE; METABOLISM; NEUTROPHIL; PATHOLOGY;

ADULT; ALPHA 1-ANTITRYPSIN DEFICIENCY; CHEMOTACTIC FACTORS; FEMALE; HUMAN; LEUKOCYTE COUNT; LEUKOCYTE ELASTASE; LEUKOTRIENE B4; LUNG; MACROPHAGES; MALE; MIDDLE AGE; NEUTROPHILS; PANCREATIC ELASTASE; PULMONARY ALVEOLI;

EID: 0026229834     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI115391     Document Type: Article

References (62)

1. Gadek, J. E., and R. G. Crystal. 1982. α1-antitrypsin deficiency. In The Metabolic Basis of Inherited Disease. J. B. Stanbury, J. B. Wyngaarden, D. S. Fredrickson, J. L. Goldstein, and M. S. Brown, editors. McGraw-Hill Book Co., New York. 1450-1467.
2. Keuppers, R., and L. F. Black. 1974. α1-Antitrypsin and its deficiency. Am. Rev. Respir. Dis. 110:176-194.
3. Crystal, R. G., M. L. Brantly, R. C. Hubbard, D. T. Curiel, D. J. States, and M. D. Holmes. 1989. The α1-antitrypsin gene and its mutations: clinical consequences and strategies for therapy. Chest. 95:196-208.
4. Brantly, M., T. Nukiwa, and R. G. Crystal. 1988. Molecular basis of α1-antitrypsin deficiency. Am. J. Med. 84:13-31.
5. Hubbard, R. C., and R. G. Crystal. 1988. Alpha 1-antitrypsin augmentation therapy for alpha 1-antitrypsin deficiency. Am. J. Med. 84:52-62.
6. Morse, J. O. 1978. Alpha 1-antitrypsin deficiency. N. Engl. J. Med. 299:1045-1048; 1099-1105.
7. Gadek, J. E., G. A. Fells, R. L. Zimmerman, S. I. Rennard, and R. G. Crystal. 1981. Antielastases of the human alveolar structures. J. Clin. Invest. 68:889-898.
8. Janoff, A. 1985. Elastases and emphysema: current assessment of the protease-antiprotease hypothesis. Am. Rev. Respir. Dis. 132:417-433.
9. Gadek, J. E., G. W. Hunninghake, G. A. Fells, R. L. Zimmerman, B. A. Keogh, and R. G. Crystal. 1980. Evaluation of the protease-antiprotease theory of human destructive lung disease. Bull. Eur. Physiopathol. Respir. 16:27-40.
10. Bieth, J. G. 1986. Elastases: catalytic and biological properties. In Regulation of Matrix Accumulation. R. Mechan, editor. Academic Press, Inc., New York. 217-320.
11. Gadek, J. E., G. W. Hunninghake, G. A. Fells, R. L. Zimmerman, B. A. Keogh, and R. G. Crystal. 1981. Validation of the alpha 1-antitrypsin recovery of active, connective tissue-specific proteases from the lung of PiZ patients and reversal with alpha 1-antitrypsin replacement therapy. Clin. Res. 49:550A. (Abstr.)
12. Keogh, B. A., J. E. Gadek, G. W. Hunninghake, and R. G. Crystal. 1982. Determinants of disease expression in PiZZ phenotype alpha 1-antitrypsin deficiency. Clin. Res. 30:432A. (Abstr.)
13. Kazmierowski, J. A., J. I. Gallin, and H. Y. Reynolds. 1977. Mechanism for the inflammatory response in primate lungs. Demonstration and partial characterization of an alveolar macrophage-derived chemotactic factor with preferential activity for polymorphonuclear leukocytes. J. Clin. Invest. 59:273-281.
14. Hunninghake, G. W., J. E. Gadek, T. J. Lawley, and R. G. Crystal. 1981. Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary fibrosis. J. Clin. Invest. 68:259-269.
15. Gadek, J. E., G. W. Hunninghake, R. L. Zimmerman, and R. G. Crystal. 1980. Regulation of the release of alveolar macrophage-derived neutrophil chemotactic factor. Am. Rev. Respir. Dis 121:723-733.
16. 4. Proc. Natl. Acad. Sci USA. 79:7866-7870.
17. 4 production by the human alveolar macrophage: a potential mechanism for amplifying inflammation in the lung. Am. Rev. Respir Dis. 129:106-111.
18. 4 in response to IgG stimulation. J. Clin. Invest. 83:1691-1700.
19. Merrill, W. W., G. P. Nagel, R. A. Matthay, and H. Y. Reynolds. 1980. Alveolar macrophage-derived chemotactic factor. Kinetics and in vitro production and partial characterization. J. Clin. Invest. 65:268-276.
20. Campbell, E. J., R. R. White, R. M. Senior, R. J. Rodriguez, and C. Kuhn. 1979. Receptor-mediated binding and internalization of leukocyte elastase by alveolar macrophages in vitro. J. Clin. Invest. 64:824-833.
21. Campbell, E. J. 1982. Human leukocyte elastase, cathespin G, and lactoferrin: family of neutrophil granule glycoproteins that bind to an alveolar macrophage receptor. Proc. Natl. Acad. Sci. USA. 79:6941-6945.
22. McGowan, S. E., R. D. Arbeit, P. J. Stone, and G. L. Snider. 1983. A comparison of the binding and fate of internalized neutrophil elastase in human monocytes and alveolar macrophages. Am. Rev. Respir. Dis. 128:688-694.
23. Wewers, M. D., M. A. Casolaro, S. E. Sellers, S. C. Swayze, K. M. McPhaul, J. T. Wittes, and R. G. Crystal. 1987. Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema. N. Engl. J. Med. 316:1055-1062.
24. Cox, D. W., A. M. Johnson, and M. K. Fagerhol. 1980. Report of nomenclature meeting for α1-antitrypsin. Hum. Genet. 53:429-433.
25. Fulmer, J. D., W. C. Roberts, E. R. Von Gal, and R. G. Crystal. 1979. Morphologic-physiologic correlates of the severity of fibrosis and degree of cellularity in idiopathic pulmonary fibrosis. J. Clin. Invest. 63:665-676.
26. Saltini, C., A. J. Hance, V. J. Ferrans, F. Basset, P. B. Bitterman, and R. G. Crystal. 1984. Accurate quantification of cells recovered by bronchoalveolar lavage. Am. Rev. Respir. Dis. 130:650-658.
27. Rennard, S. I., G. Basset, D. Lecossier, K. M. O'Donnell, P. G. Martin, and R. G. Crystal. 1986. Estimation of the apparent volume of epithelial lining fluid recovered by bronchoalveolar lavage using urea as an endogenous marker of dilution. J. Appl. Physiol. 60:532-658.
28. Harvath, L., W. Falk, and E. J. Leonard. 1980. Rapid quantitation of neutrophil chemotaxis: use of a polyvinylpyrrolidone-free polycarbonate membrane in a multiwell assembly. J. Immunol. Methods. 37:39-45.
29. Boynum, A. 1968. Isolation of mononuclear cells and granulocytes from human blood. J. Clin. Invest. 21:77-89.
30. Henke, D. C., S. Kouzan, and T. E. Eling. 1984. Analysis of leukotnenes, prostaglandins, and other oxygenated metabolites of arachidonic acid by high-performance liquid chromatography. Anal. Biochem. 140:87-94.
31. Humes, J. L. 1981. Prostaglandins. In Methods for Studying Mononuclear Phagocytes. D. A. Adams, H. Kuren, and P. Edelson, editors. Academic Press, Inc., New York. 541-654.
32. Rokach, J., E. C. Hayes, Y. Girard, D. Lombarde, A. L. Maycock, A. S. Rosental, R. N. Young, R. Zamboni, and H. J. Zweerink. 1984. The development of sensitive and specific radioimmunoassays for leukotnenes. Prostaglandins Leukotrienes Med. 13:21-25.
33. Ogushi, F., G. A. Fells, R. C. Hubbard, S. D. Straus, and R. G. Crystal. 1987. Z-Type α1-antitrypsin is less competent than M1 -type α1-antitrypsin as an inhibitor of neutrophil elastase. J. Clin. Invest. 80:1366-1374.
34. Henson, P. M., G. L. Larsen, and R. V. Webster. 1982. Pulmonary microvascular alterations and injury induced by complement fragments. Synergistic effects of complement fragments: complement activation, neutrophil sequestration and prostaglandins. Ann. NY Acad. Sci. 384:287-300.
35. Gosset, P., A. B. Tonnel, M. Joseph, L. Prin, A. Mallart, J. Charon, and A. Capron. 1984. Secretion of a chemotactic factor for neutrophils and eosinophils by alveolar macrophages from asthmatic patients. J. Allergy Clin. Immunol. 74:827-834.
36. Fowler, A. A., and L. B. Schwartz. 1984. Macrophage-derived chemotactic factors and allergic asthma. J. Allergy Clin. Immunol. 74:777-780.
37. Kew, R. R., B. Ghebrehiwet, and A. Janoff. 1986. The role of complement in cigarette smoke-induced chemotactic activity of lung fluids. Am. Rev. Respir. Dis. 133:478-481.
38. Laskin, D. L., T. Kimura, S. Sakakibara, D. J. Riley, and R. A. Berg. 1986. Chemotactic activity of collagen-like polypeptides for human peripheral blood neutrophils. J. Leukocyte Biol. 39:255-266.
39. 4 to the neutrophil chemotactic activity produced by the resident human alveolar macrophage. J. Clin. Invest. 80:1114-1124.
40. Worthen, G. S., C. Haslett, A. J. Rees, R. S. Gumbay, J. E. Henson, and P. M. Henson. 1987. Neutrophil-mediated pulmonary vascular injury. Synergistic effect of trace amounts of lipopolysaccharide and neutrophil stimuli on vascular permeability and neutrophil sequestration in the lung. Am. Rev. Respir Dis. 136:19-28.
41. Sylvester, I., J. A. Rankin, T. Yoshimura, S. Tanaka, and E. J. Leonard. 1990. Secretion of neutrophil attractant/activation protein (NAP-1/IL-8) by lipopolysaccharide-stimulated lung macrophages. Am. Rev. Respir. Dis. 141:683-688.
42. Pierce, J. A., and R. M. Senior. 1981. Alveolar macrophage secrets. J. Lab. Clin. Med. 97:463-466.
43. Reiko, T., and Z. Werb. 1984. Secretory products of macrophages and their physiological functions. Am. Physiol. Soc. 246(Cell Physiol. 15):C1-C9.
44. Nathan, C. F. 1987. Secretory products of macrophages. J. Clin. Invest. 79:319-326.
45. 4 synthesis in smokers' alveolar macrophages in vitro. J. Clin. Invest. 77:54-60.
46. Schoenberger, C. I., G. W. Hunninghake, O. Kawanami, V. J. Ferrans, and R. G. Crystal. 1982. Role of alveolar macrophages in asbestosis: modulation of neutrophil migration to the lung after acute asbestos exposure. Thorax. 37:803-809.
47. Rola-Pleszynski, M., S. Gouin, and R. Begin. 1984. Asbestos-induced lung inflammation: role of local macrophage-derived chemotactic factors in accumulation of neutrophils in the lungs. Inflammation. 8:53-61.
48. Wesselius, L. J., A. Catanzaro, and S. I. Wasserman. 1984. Neutrophil chemotactic activity generation by alveolar macrophages after bleomycin injury. Am. Rev. Respir. Dis. 129:485-490.
49. Campbell, E. J., and M. S. Wald. 1983. Hypoxic injury to human alveolar macrophages accelerates release of previously bound neutrophil elastase: implications for lung connective tissue injury including pulmonary emphysema. Am. Rev. Respir. Dis. 127:631-635.
50. Kaplan, J., and M. L. Nielsen. 1979. Analysis of macrophage surface receptors. I. Binding of α2-macroglobulin-protease complexes to rabbit alveolar macrophages. J. Biol. Chem. 254:7323-7328.
51. Chang, J., F. Wigley, and D. Newcombe. 1980. Neutral protease activation of peritoneal macrophage prostaglandin synthesis. Proc. Natl. Acad. Sci. USA. 77:4736-4740.
52. Travis, J., and G. S. Salveson. 1983. Human plasma proteinase inhibitors. Annu Rev. Biochem. 52:655-709.
53. Beatty, K., J. Bieth, and J. Travis. 1980. Kinetics of association of serine proteinase with native and oxidized α1-proteinase inhibitor and α1-antichymotrypsin. J. Biol. Chem. 255:3931-3934.
54. Carp, H., F. Miller, J. R. Hoidal, and A. Janoff. 1982. Potential mechanism of emphysema: α1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity. Proc. Natl. Acad. Sci. USA. 79:2041-2045.
55. Gadek, J. E., G. A. Fells, and R. G. Crystal. 1979. Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans. Science (Wash. DC) 206:1315-1316.
56. Cohen, A. B. 1979. The effects of in vivo and in vitro oxidative damage to purified α1-antitrypsin and to the enzyme-inhibiting activity of plasma. Am. Rev. Respir.Dis. 119:953-960.
57. Cochrane, C. G., R. Spragg. and S. D. Revak. 1983. Pathogenesis of the adult respiratory distress syndrome: evidence of oxidant activity in bronchoalveolar lavage fluid. J Clin. Invest. 71:754-761.
58. Goldstein, W., and G. Doring. 1986. Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis. Am. Rev. Respir. Dis. 134:49-56.
59. Hubbard, R. C., and R. G. Crystal. 1986. Antiproteases and antioxidants: strategies for the pharmacologic prevention of lung destruction. Respiration. 50:56-73.
60. Hubbard, R. C., F. Ogushi, G. A. Fells, A. M. Cantin, S. Jallat, M. Courtney, and R. G. Crystal. 1987. Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of α1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase. J. Clin. Invest. 80:1289-1295.
61. Banda, M. J., A. G. Rice, G. L. Griffin, and R. M. Senior. 1988. α1-Proteinase inhibitor is a neutrophil chemoattractant after proteolytic inactivation by macrophage elastase. J. Biol. Chem. 263:4481-4484.
62. Banda, M. J., A. G. Rice, G. L. Griffin, and R. M. Senior. 1988. The inhibitory complex of human α1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant. J. Exp. Med. 167:1608-1615.