Molecular cloning and sequence of porcine interleukin 6 cDNA and expression of mRNA in synovial fibroblasts in vitro

Cytokine

Volumn 3, Issue 4, 1991, Pages 269-276

  Richards, Carl D ^a   Saklatvala, Jeremy ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

cytokines; fibroblasts; interleukin 6; synovium

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR; INTERLEUKIN 1; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOSYNTHESIS; FIBROBLAST; GENE EXPRESSION; GENETICS; IMMUNOLOGY; IN VITRO STUDY; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SWINE; SYNOVIUM;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; CLONING, MOLECULAR; DNA; EPIDERMAL GROWTH FACTOR; FIBROBLASTS; GENE EXPRESSION; IN VITRO; INTERLEUKIN-1; INTERLEUKIN-6; MOLECULAR SEQUENCE DATA; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SWINE; SYNOVIAL MEMBRANE; TUMOR NECROSIS FACTOR;

EID: 0026199268     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/1043-4666(91)90494-X     Document Type: Article

References (50)

1. Interleukin-1
2. Biology of Disease
3. Interleukin-6 in the inflammatory response
4. Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation
5. Interferonβ2/B-cell stimulatory factor type 2 shares identity with monocyte hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells
6. Interaction between Hepatocyte-Stimulating factors, Interleukin-1 and glucocorticoids for regulation of acute phase proteins in human hepatoma (Hep-G2) cells
7. Action of recombinant Interleukin-6 Interleukin-1β and Tumour Necrosis Factor on the mRNA induction of acute phase protein
8. Induction of rat acute-phase proteins by Interleukin-6 in vivo
9. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
10. Molecular regulation of B lymphocyte response
11. Interleukin-1 and poly(rI):poly(rC) induce production of a hybridoma growth factor by human fibroblasts
12. 2, HPGF)
13. B cell stimulatory-2 is involved in the differentiation of cytotoxic T-lymphocytes
14. Multiple actions of Interleukin-6 in a cytokine network
15. Phorbol ester modulates interleukin 6- and interleukin 1-regulated expression of acute phase plasma proteins in hepatoma cells
16. 2 receptor
17. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
18. 2 interferon and β-cell differentiation factor BSF-2 are identical
19. Serum levels of Interleukin-6 and acute phase responses
20. Elevated levels of the 26K human hybridoma growth factor (IL-6) in cerebrospinal fluid of patients with acute infections of the central nernous system
21. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides
22. Excessive production of interleukin-6/B cell stimulatory factor-2 in rheumatoid arthritis
23. Structural analysis of the sequence coding for an inducible 26-kda protein in human fibroblast
24. Molecular cloning and expression of hybridoma growth factor in Escherichia coli
25. 2, a distinct species inducible by growth stimulating cytokines
26. cDNA cloning of murine interleukin-HP1: Homology with human interleukin 6
27. Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells
28. Genomic structure of the murine IL-6 gene
29. The cartilage-resorbing protein catabolin is made by synovial fibroblasts and its production is increased by phorbol myristate acetate
30. Identification of high affinity receptors for both types of porcine interleukin-1 on connective tissue cells
31. Properties of pig synovial collagenase
32. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
33. The structure and function of the mouse hepatocyte stimulating factor
34. Production of hybridoma growth factor by human monocytes
35. 2-Interferon/B-cell Differentiation Factor-2/Hepatocyte stimulating factor by human fibroblasts and monocytes
36. The microenvironmental differentiation hypothesis of airway inflammation
37. Synovium as a source of Interleukin-6 in vitro
38. IL-6 is the principle factor produced by synovia of patients with rheumatoid arthritis that induces B-lymphocytes to secrete immunoglobulins
39. Regulation of human synovial fibroblast collagenase messenger RNA by Interleukin-1
40. Transforming growth factor-B: Biological function and chemical structure
41. Inflammatory and immunomodulatory roles of TGF-β
42. Transforming growth factor-β production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats
43. Transforming growth factor Beta 1 (TGF-beta 1) and recombinant human tumour necrosis factor reciprically regulate the generation of lymphokine-activated killer cell activity
44. Inhibition of cytotoxic T-cell development by transforming growth factor-β and reversal by touour necrosis factor
45. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor
46. Porcine collagenase from synovial fibroblasts: cDNA sequence and modulation of expression of RNA in vitro by various cytokines
47. TGF-B1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence
48. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
49. DNA sequencing with chain termination inhibitors