Evidence that genistein, a protein-tyrosine kinase inhibitor, inhibits CD28 monoclonal-antibody-stimulated human T cell proliferation

Transplantation

Volumn 51, Issue 2, 1991, Pages 448-450

  Atluru, Subbayamma ^a   Atluru, Durgaprasadarao ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENISTEIN; INTERLEUKIN 2; MONOCLONAL ANTIBODY;

ADULT; CONFERENCE PAPER; GRAFT REJECTION; HUMAN; HUMAN EXPERIMENT; NEPHROTOXICITY; NORMAL HUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELL SURVIVAL; CYCLOSPORINS; GENISTEIN; HUMAN; IN VITRO; INTERLEUKIN-2; ISOFLAVONES; PROTEIN-TYROSINE KINASE; RECEPTORS, INTERLEUKIN-2; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026101639     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199102000-00035     Document Type: Article

References (16)

1. June CH, Ledbetter JA, Lindsten T, Thompson CB. Evidence for the involvement of three distinct signals in the induction of IL- 2 gene expression in human T lymphocytes. J Immunol 1989; 143: 153.
2. Thompson CB, Lindsten T, Ledbetter JA, et al. CD28 activation pathway regulates the production of multiple T-cell-derived lym- phokines/cytokines. Proc Natl Acad Sci USA 1989; 86: 1333.
3. Aruffo A, Seed B. Molecular cloning of CD28 cDNA by a high efficiency COS cell expression system. Proc Natl Acad Sci USA 1987; 84: 8573.
4. Yamada H, Martin PJ, Bean MA, et al. Monoclonal antibody 9.3 and anti-CD 11 antibodies define reciprocal subsets of lymphocytes. Eur J Immunol 1985; 15: 1164.
5. Akjiyama T, Ishida J, Nakagawa S, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinase. J Biol Chem 1987; 262: 5592.
6. Trevillyan JM, Bjorndhal JM, Lu Y, Atluru D. Inhibition of T-lymphocyte activation by a selective inhibitor of protein-tyrosine kinase. Blood 1989; 74: 225.
7. Mustelin T, Coggeshall KM, Isakov N, Altman A. T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation. Science 1990; 247: 1584.
8. Markovits J, Linassier C, Fosse P, et al. Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoi- somerase II. Cancer Res 1989; 49: 511.
9. Atluru D, Goodwin JS. Control of polyclonal immunoglobulin production from human lymphocytes by leukotrienes: leukotriene B4 induces an OKT8(+), radiosensitive suppressor cell from resting, human OKT8(+) T-cells. J Clin Invest 1984; 74: 1444.
10. Gualde N, Atluru D, Goodwin JS. Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T-cells and T-cell subsets. J Immunol 1985; 134:1125.
11. Atluru D, Polam S, Atluru S, Woloschak GE. Regulation of mitogen stimulated human T-cell proliferation, interleukin-2 production and interleukin-2 receptor expression by protein kinase C inhib-itor, H-7. Cell Immunol 1990; 129: 310.
12. Imboden JB, Stobo JD. Transmembrane signaling by the T-cell antigen receptor: pertrubation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. J Exp Med 1985; 161: 446.
13. Ledbetter JA, Gentry LE, June CH, Rabinovitch PS, Purchio AF. Stimulation of T-cells through the CD?, T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation and phosphorylation of pp60C-src in the activation pathway. Mol Cell Biol 1987; 7: 650.
14. Ledbetter JA, Parsons M, Martin PJ, Hansen JA, Rabinovitch PS, June CH. Antibody bending to CD5 (TP67) and TP44 T cell surface molecules: effects of cyclicnucleotides, cytoplasmic free calcium and cAMP-mediated suppression. J Immunol 1986; 137: 3299.
15. Atluru S, Woloschak GE, McVey DS, Gudapaty S, Atluru D. Cyclosporin A and FK-506: in vitro effects on proliferation of human T-cells. Biochem Arch 1990; 6: 397.
16. Atluru S, Jackson TM, Atluru D. Is protein tyrosine kinase nec essary for the induction of LTB4 from human mononuclear cells? Am Soc Biochem Mol Biol/Am Assoc Immunol 1990; 4: 2915.