A Novel Dipyridodiazepinone Inhibitor of HIV-1 Reverse Transcriptase Acts through a Nonsubstrate Binding Site

Biochemistry

Volumn 30, Issue 8, 1991, Pages 2022-2026

  Wu, Joe C ^a   Warren, Thomas C ^a   Farina, Peter R ^a   Grob, Peter M ^a   Adams, Julian ^a   Proudfoot, John ^a   Skiles, Jerry ^a   Raghavan, Palayakotai ^a   Perry, Clark ^a   Potocki, Ian ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BENZODIAZEPINE DERIVATIVE; ENZYME INHIBITOR; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE;

ARTICLE; ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; ULTRAVIOLET RADIATION;

AFFINITY LABELS; ANTIVIRAL AGENTS; BINDING SITES; BLOOD PROTEINS; COMPARATIVE STUDY; ESCHERICHIA COLI; HIV-1; HUMAN; KINETICS; LEUKOCYTES; NEVIRAPINE; PROTEIN BINDING; PYRIDINES; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE INHIBITORS; RNA-DIRECTED DNA POLYMERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0026100860     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00222a003     Document Type: Article

References (15)

1. D’Aquila, R. T., & Summers, W. (1989) J. Acquired Immune Defic. Syndr. 2, 579-587.
2. DeClercq, E. (1989) Antiviral Res. 12, 1-20.
3. DeClercq, E. (1990) Trends Pharmacol. Sci. 11, 198-205.
4. Fauci, A. S. (1988) Science 239, 617-622.
5. Guyader, M., Emerman, M., Sonigo, P., Clavel, F., Montagnier, L., & Alizon, M. (1987) Nature 326, 662-669.
6. Hao, Z., Cooney, D. A., Hartman, N. R., Perno, C.-F., Fridland, A., DeVico, A. L., Samgadharan, M. G., Broder, S., & Johns, D. G. (1988) Mol. Pharmacol. 34, 431-435.
7. Hargrave, K. D., Proudfoot, J. R., Grozinger, K. G., Culien, E., Kapadia, S. R., Patel, U. R., Fuchs, V. U., Mauldin, S. C., Vitrous, J., Pal, K., Behnke, M. L., Skiles, J. W., Klunder, J. M., McNeil, D. W., Rose, J. M., Chow, G., Skoog, M. T., Wu, J. C., Schmidt, G., Engel, W. W., Eberlein, W. G., Saboe, T. D., Campbell, S. J., & Adams, J. (1991) J. Med. Chem. (in press).
8. Laemmli, U. K. (1970) Nature 227, 680-685.
9. Larder, B. A., & Kemp, S. D. (1989) Science 246, 1155-1158.
10. Merluzzi, V. J., Hargrave, K. D., Grozinger, K., Labadia, M., Eckner, K., Hattox, S., Adams, J., Rosenthal, A. S., Faanes, R., Skoog, M., Wu, J. C., Shih, C.-K., Eckner, R., Koup, R. A., & Sullivan, J. L. (1990) Science 250, 1411-1413.
11. Mizrahi, V., Lazarus, G. M., Miles, L. M., Meyers, C. A., & Dcbcouck, C. (1989) Arch. Biochem. Biophys. 273, 347-358.
12. Pauwels, R., Andries, K., Dcsmyter, J., Schols, D., Kukla, M. J., Breslin, H. J., Raeymaeckers, A., VanGelder, J., Woesteinborghs, R., Heykants, J., Schellekens, K., Janssen, M. A., DcClercq, E., & Janssen, P. A. (1990) Nature 343, 470-474.
13. Richman, D. D., Fischi, M. A., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., Leedom, J. M., Groopman, J. E., Mildvan, D., Hirsch, M. S., Jackson, G. G., Durack, D. T., & Lchrman-Nusinoff, S. (1987) N. Engl. J. Med. 317, 192-197.
14. Starnes, M. C., & Cheng, Y.-C. (1987) J. Biol. Chem. 262, 988-991.
15. Wu, J. C., Chuan, H., & Wang, J. H. (1989) J. Biol. Chem. 264, 7989-7993.