Potential Antitumor Agents. 61. Structure-Activity Relationships for in Vivo Colon 38 Activity among Disubstituted 9-Oxo-9H-xanthene-4-acetic Acids

Journal of Medicinal Chemistry

Volumn 34, Issue 1, 1991, Pages 217-222

  Rewcastle, Gordon W ^a   Atwell, Graham J ^a   Zhuang, Li ^a   Baguley, Bruce C ^a   Denny, William A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

4' (9 ACRIDINYLAMINO)METHANESULFONANILIDE; 5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; ANTINEOPLASTIC AGENT; MITOFLAXONE; UNCLASSIFIED DRUG; XANTHENE DERIVATIVE; XANTHONE 4 ACETIC ACID DERIVATIVE;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; COLON CANCER; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0026100365     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00105a034     Document Type: Article

References (25)

1. Atassi, G.; Briet, P.; Berthelon, J.-J.; Collonges, F. Eur. J. Med. Chem. 1985, 20, 393.
2. Plowman, J.; Narayanan, V. L.; Dykes, D.; Szarvasi, E.; Briet, P.; Yoder, O. C.; Pauli, K. D. Cancer Treatment Rep. 1986, 70, 631.
3. Smith, G. P.; Calveley, S. B.; Smith, M. J.; Baguley, B. C. Eur. J. Cancer. Clin. Oncol. 1987, 23, 1209.
4. Hornung, R. L.; Back, T. C.; Zaharto, D. S.; Urba, W. J.; Longo, D. L.; Wiltrout, R. H. J. Immunol. 1988, 141, 3671.
5. Ching, L.-M.; Baguley, B. C. Eur. J. Cancer 1989, 25, 821.
6. Mace, K. F.; Hornung, R. L.; Wiltrout, R. H.; Young, H. A. Cancer Res. 1990, 50, 1742.
7. Bibby, M. C.; Double, J. A.; Loadman, P. M.; Duke, C. V. JNCI, J. Natl. Cancer Inst. 1989, 81, 216.
8. Zwi, L. J.; Baguley, B. C.; Gavin, J. B.; Wilson, W. R. JNCI, J. Natl. Cancer Inst. 1989, 81, 1005.
9. Kerr, D. J.; Kaye, S. B. Eur. J. Cancer Clin. Oncol. 1989, 25, 1271.
10. Rewcastle, G. W.; Atwell, G. J.; Baguley, B. C.; Calveley, S. B.; Denny, W. A. J. Med. Chem. 1989, 32, 793.
11. Atwell, G. J.; Rewcastle, G. W.; Baguley, B. C.; Denny, W. A. J. Med. Chem. 1990, 33, 1375.
12. Ching, L.-M.; Joseph, W. R.; Zhuang, L.; Atwell, G. J.; Rewcastle, G. W.; Denny, W. A.; Baguley, B. C. Eur. J. Cancer, in press.
13. Baguley, B. C.; Denny, W. A.; Atwell, G. J.; Rewcastle, G. W.; Ching, L.-M.; Thomsen, L. L.; Zhuang, L. Proc. Am. Assoc. Cancer Res. 1990, 81, abstr. no. 2451.
14. Soula, G. J. Org. Chem. 1985, 50, 3717.
15. Baguley, B. C.; Calveley, S. B.; Crowe, K. K.; Fray, L. M.; O’Rourke, S. M.; Smith, G. P. Eur. J. Cancer Clin. Oncol. 1989, 25, 263.
16. Kestell, P.; McKeage, M. J., unpublished results, this laboratory.
17. Ford, R. E.; Knowles, P.; Lunt, E.; Marshall, S. M.; Penrose, A. J.; Ramsden, C. A.; Summers, A. J. H.; Walker, J. L.; Wright, D. E. J. Med. Chem. 1986, 29, 538.
18. Aubert, O.; Augdahl, E.; Berner, E. Acta Chem. Scand. 1952, 6, 433.
19. Baker, B. R.; Schaub, R. E.; Joseph, J. P.; McEvoy, F. J.; Williams J. H. J. Org. Chem. 1952, 17, 149.
20. Demerson, C. A.; Humber, L. G.; Philipp, A. H.; Martel, R. R. J. Med. Chem. 1976, 19, 391.
21. Carde, R. N.; Jones, G. J. J. Chem. Soc., Perkin Trans. 1 1975, 519.
22. Rewcastle, G. W.; Kestell, P.; Baguley, B. C.; Denny, W. A. JNCI, J. Natl. Cancer Inst. 1990, 82, 528.
23. Denny, W. A.; Cain, B. F. J. Med. Chem. 1978, 21, 430.
24. Sadler, P. W.; Warren, R. L. J. Am. Chem. Soc 1956, 78, 1251.
25. Baker, B. R.; Joseph, J. P.; Schaub, R. E.; McEvoy, F. J.; Williams, J. H. J. Org. Chem. 1952, 17, 157.