Synthesis of Water-Soluble (Aminoalkyl)camptothecin Analogues: Inhibition of Topoisomerase I and Antitumor Activity

Journal of Medicinal Chemistry

Volumn 34, Issue 1, 1991, Pages 98-107

  Kingsbury, William D ^a   Boehm, Jeffrey C ^a   Jakas, Dalia R ^a   Holden, Kenneth G ^a   Gallagher, Gregory ^a   Caranfa, Mary Jo ^a   McCabe, Francis L ^a   Faucette, Leo F ^a   Johnson, Randall K ^a   Hertzberg, Robert P ^a   Hecht, Sidney M ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; TOPOTECAN;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; CYTOTOXICITY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME INHIBITION; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA; LEUKEMIA L 1210; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMAL; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CATTLE; CELL LINE; COLONIC NEOPLASMS; COMPARATIVE STUDY; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMAN; INDICATORS AND REAGENTS; LEUKEMIA L1210; LUNG NEOPLASMS; MELANOMA, EXPERIMENTAL; MICE; MOLECULAR STRUCTURE; PLASMIDS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, P.H.S.; THYMUS GLAND; TRANSPLANTATION, HETEROLOGOUS;

EID: 0026099599     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00105a017     Document Type: Article

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