Percutaneous absorption of parathion in Vitro in porcine skin: Effects of dose, temperature, humidity, and perfusate composition on absorptive flux

Toxicological Sciences

Volumn 17, Issue 3, 1991, Pages 494-504

  Chang, S K ^a   Riviere, J E ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHION;

ANIMAL TISSUE; ARTICLE; FEMALE; HUMIDITY; NONHUMAN; SKIN ABSORPTION; SWINE; TEMPERATURE; TISSUE PERFUSION;

ANIMAL; DIFFUSION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMIDITY; IN VITRO; PARATHION; SKIN ABSORPTION; SUPPORT, U.S. GOV'T, P.H.S.; SWINE; TEMPERATURE;

ANIMALIA; BOVINAE; SUIDAE; SUS SCROFA;

EID: 0026095272     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/17.3.494     Document Type: Article

References (40)

1. BARTEK, M. J., LABUDDE, J. A., AND MAIBACH, H. I. (1972). Skin permeability in vitro Comparison in rat, rabbit, pig, and man. J. Invest. Dermatol. 58, 114-123.
2. BRONAUGH, R. L., AND STEWARD, R. F. (1984). Methods for in vitro percutaneous absorption studies. III. Hydrophobic compounds. J. Pharm. Sci. 73, 1255-1258.
3. BRONAUGH, R. L., AND STEWARD, R. F. (1985). Methods for in vitro percutaneous absorption studies. IV. The flow-through diffusion cell. J Pharm Sci. 74, 64-67.
4. BUCKS, D. A. W., MAIBACH, H. I., AND GUY, R. H. (1989). In Percutaneous Absorption (R. L. Bronaugh and H. I. Maibach, Eds.), pp 77-93. Marcel Dekker, New York.
5. CARVER, M. P., LEVI, P. E., AND RJVIERE, J. E. (1990). Parathion metabolism during percutaneous absorption in perfused porcine skin. Pestic. Biochem. Physiol 38, 245-254.
6. COOPER, E. R., MERRITT, E. W" AND SMITH, R. L. (1985). Effect of fatty acids and alcohols on the penetration of acyclovir across human skin in vitro J Pharm Sci. 74, 688-689.
7. CRAIG, F. N., CUMMINGS, E. G., AND SIM, V. M. (1977). Environmental temperature and the percutaneous absorption of a cholinesterase inhibitor, VX. J. Invest Dermatol. 68, 357-362.
8. Crutcher, W., AND Maibach, H. I. (1969). The effect of perfusion rate on in vitro percutaneous penetration. J Invest Dermatol 53, 264-269.
9. CUMMINGS, E. G. (1969). Temperature and concentration effects on penetration of A’-octylamine through human skin in situ. J Invest Dermatol 53, 64-70.
10. DURHAM, W. F. (1965). Pesticide exposure levels in man and animals. Arch Environ. Health 10, 842-846.
11. DURHAM, W. F., WOLFE, H. R., AND ELLIOT, J. W. (1972). Absorption and excretion of parathion by sprayman. Arch Environ. Health 24, 381-387.
12. DURHAM, W. F., WOLFE, H. R" AND FLYNN, G. L. (1962). Measurement of the exposure of workers to pesticides. Bull WHO 26, 75-91.
13. ELIAS, P. M., COOPER, E. R" KORC, A., AND BROWN. B. E. (1981). Percutaneous transport in relation to stratum comeum structure and lipid composition. J Invest Dermatol. 76, 297-301.
14. FELDMANN, R. J., AND MAIBACH, H. I. (1970). Absorption of some organic compounds through the skin in man. J Invest. Dermatol 54, 399-404.
15. FELDMANN, R. AND MAIBACH, H. I. (1974a). Percutaneous penetration of some pesticides and herbicides in man. Toxicol. Appl. Pharmacol. 28, 126-132.
16. FELDMANN, R. J" AND MAIBACH, H. I. (1974b). Percutaneous penetration of hydrocortisone with urea. Arch. Dermatol 109, 58-59.
17. GRISSOM, R. E., BROWNIE, C., AND GUTHRIE, F. E. (1985). Dermal absorption of pesticides in mice. Pestic Biochem. Physio! 24, 119-123.
18. HAWKINS, G. S., AND REIFENRATH, W. G. (1984). Development of an in vitro model for determining the fate of chemical applied to skin. Fundam. Appl. Toxicol 4, S133-S144.
19. HAYES, G. R., FUNCKES, A. J., AND HARTWELL, W. V. (1964). Dermal exposure of human volunteers to para-thion. Arch. Environ. Health 8, 829-833.
20. LIRON, Z., AND COHEN, S. (1984). Percutaneous absorption of alkanoic acids. 1. A study of operational conditions. J. Pharm Sci. 73, 534-537.
21. Maibach, H. I., Feldmann, R. J., Milby, T. H., and Serat, W. F. (1971). Regional variation in percutaneous penetration in man. Arch. Environ Health 23, 208-211.
22. MEYER, W., SCHWARZ, R., AND NEURAND, K. (1978). The skin of domestic mammals as a model for the human skin, with special reference to the domestic pig. Curr. Probl. Dermatol. 7, 39-52.
23. MONTEIRO-RJVIERE, N A. (1986). Ultrastructure evaluation of the porcine integument. In Swine Biomedical Research (M. E. Tumbleson, Ed.), pp. 641-655. Plenum.
24. NAMBA, T" NOLTE, C. T., AND JACKREL, J. (1971). Poisoning due to organophosphate insecticides. Acute and chronic manifestations. Am J. Med. 50, 475-492.
25. REIFENRATH, W. G., CHELLQUIST, E. M., SHIPWASH, E. A., AND JEDERBERG, W. W. (1984). Evaluation of animal models for predicting skin penetration in man. Fundam. Appl Toxicol. 4, S224-S230.
26. REIFENRATH, W. G., CHELLQUIST, E. M., SHIPWASH, E. A., JEDERBERG, W. w" AND KRUEGER, G. G. (1984). Percutaneous penetration in the hairless dog, weanling pig and grafted athymic nude mouse: Evaluation of models for predicting skin penetration in man. Br. J. Dermatol. III (Suppl. 27), 123-135.
27. RIVIERE, J. E., BOWMAN, K. F., MONTEIRO-RJVIERE, N. A., DIX, L. P., AND CARVER, M. P. (1986). The isolated perfused porcine skin flap (IPPSF). I. A novel in vitro model for percutaneous absorption and cutaneous toxicology studies. Fundam. Appl. Toxicol. 7, 444-453.
28. SHAH, P. V., FISHER, H. L., SUMLER, M. R., MONROE, R. J., CHERNOFF, N., AND HALL, L. L. (1987). Comparison of the penetration of 14 pesticides through the skin of young and adult rats. J. Toxicol. Environ. Health 21, 353-366.
29. SHAH, P. V., MONROE, R. J., AND GUTHRIE, F. E. (1983). Comparative penetration of insecticides in target and nontarget species. Drug Chem Toxicol. 6, 155-179.
30. SHAW, J. E" TASKAVICH, L., AND CHANDERASEKARAN, S. K. (1980). In Current Concept in Cutaneous Toxicity (V. A. Drill and P. Lazar, Eds.), p. 127. Academic Press, New York.
31. SHEHATA-KARAM, H., MONTEIRO-RIVIERE, N. A., AND GUTHRIE, F. E. (1988). In vitro penetration of pesticides through human newborn foreskin. Toxicol. Lett. 40, 233-239.
32. SIMPSON, G. R. (1965). Exposure to orchard pesticides. Dermal and inhalation exposures. Arch. Environ Health 10, 884-885.
33. 1, 4C parathion in the mouse: Effect of anatomic region. J Toxicol Environ. Health 9, 483-490.
34. STOUGHTON, R. B. (1982). Enhanced percutaneous penetration with l-dodecylazacycloheptan-2-one. Arch. Dermatol 118, 474-477.
35. WESTER, R. C., AND MAIBACH, H. I. (1976). Relationship of topic dose and percutaneous absorption on rhesus monkey and man. J. Invest. Dermatol. 67, 518-520.
36. WESTER, R. C., AND MAIBACH, H. I. (1985). In vivo percutaneous absorption and decontamination of pesticides in humans. J. Toxicol. Environ. Health 16, 25-37.
37. WESTER, R. C., NOONAN, P. K., COLE, M. P., AND MAIBACH, H. I. (1977). Percutaneous absorption of testosterone in the newborn rhesus monkey: Comparison to the adult. Pediatr. Res. 11, 737-739.
38. WHANG, J. M., QUINN, J. A., GRAVES, D. J., AND NEUFELD, G. R. (1989). Permeation of inert gases through human skin: Modeling the effect of skin Wood flow. J. Appl Physiol. 67, 1670-1686.
39. WILLIAM, J. A., GORDON, L. F., AND NORMAN, W. (1987). Validation of a flow-through diffusion cell for use in transdenmal research. Pharm. Res. 4, 337-341.
40. WOLFE, H. R., ARMSTRONG, J. F., AND DURHAM, W. F. (1966). Pesticide exposure from concentrate spraying. Arch. Environ. Health 13, 340-344.