Antiulcer Agents. 5. Inhibition of Gastric H+/K+-ATPase by Substituted Imidazo[1,2-a]pyridines and Related Analogues and Its Implication in Modeling the High Affinity Potassium Ion Binding Site of the Gastric Proton Pump Enzyme

Journal of Medicinal Chemistry

Volumn 34, Issue 2, 1991, Pages 533-541

  Kaminski, James J ^a   Wallmark, Bjorn ^b   Briving, Carin ^b   Andersson, Britt Marie ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

8 BENZYLOXY 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 ACETONITRILE; ADENOSINE TRIPHOSPHATASE (POTASSIUM); ENZYME INHIBITOR; IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; PROTON PUMP;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DOG; ENZYME INHIBITION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RABBIT; STOMACH; STOMACH ACID SECRETION; STRUCTURE ACTIVITY RELATION; SWINE;

ADENOSINETRIPHOSPHATASE; ANIMAL; ANTI-ULCER AGENTS; BINDING SITES; CHEMISTRY; DOGS; GASTRIC MUCOSA; H(+)-K(+)-EXCHANGING ATPASE; IMIDAZOLES; MODELS, MOLECULAR; POTASSIUM; PYRIDINES; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0026093481     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00106a008     Document Type: Article

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