Mice lacking MHC class II molecules

Cell

Volumn 66, Issue 5, 1991, Pages 1051-1066

  Cosgrove, Dominic ^a   Gray, David ^b   Dierich, Andrée ^a   Kaufman, Jim ^b   Lemeur, Marianne ^a   Benoist, Christophe ^a   Mathis, Diane ^a  

^a INSERM   (France)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMAL; ANTIBODY FORMATION; ANTIGENS, CD4; ANTIGENS, CD8; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; B-LYMPHOCYTES; CELL DIFFERENTIATION; FLOW CYTOMETRY; GENE REARRANGEMENT, T-LYMPHOCYTE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HOMOZYGOTE; LYMPH NODES; MICE; MICE, MUTANT STRAINS; RECEPTORS, LYMPHOCYTE HOMING; SPLEEN; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; THYMUS GLAND;

ANIMALIA;

EID: 0026091380     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(91)90448-8     Document Type: Article

References (118)

1. Cytotoxic T cell clone-specific monoclonal antibodies used to select clonotypic antigen-specific cytotoxic T cells
2. In vivo expression and function of hybrid la dimers (EαAβ) in recombinant and transgenic mice
3. + T cells
4. Lymphocyte major histocompatibility complex-encoded class I I structures may act as sperm receptors
5. β polypeptides
6. Positive selection of the T cell repertoire: where and when does it occur?
7. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
8. Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection
9. A shared alloantigenic determinant on la antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication
10. The MHC molecule I-E is necessary but not sufficient for the clonal deletion of Vβ11-bearing T cells
11. Class I and class II MHC gene products differentially affect the fate of Vβ5 bearing thymocytes
12. Characterization of murine thymocytes with CD3-associated T-cell receptor structures
13. + thymocytes influenced by CD4
14. Development of the CD4 and CD8 lineage of T cells: instruction versus selection
15. + B cell subpopulation
16. Role of accessory cells in B cell activation. III. Cellular analysis of primary immune response deficits in CBA/N mice: presence of an accessory cell-B cell interaction defect
17. The mouse Eβ2 gene: a class II MHC p gene with limited intraspecies polymorphism and an unusual pattern of transcription
18. Allele specific control of la molecule surface expression and conformation: implications for a general model of la structure-function relationships
19. A monoclonal antibody discriminating between subsets of T and B cells
20. Developmentally regulated expression of T cell receptor p chain variable domains in immature thymocytes
21. Altering the genome by homologous recombination
22. Major histocompatibility complex control of T cell recognition
23. CH isotope “switching” during normal B-lymphocyte development
24. − mouse thymocytes
25. Macrophage requirement for the in vitro response to TNP-Ficoll: a thymic independent antigen
26. B220: a B cell-specific member of the T200 glycoprotein family
27. − thymocytes
28. Expression of T cell antigen receptor β-chains on subsets of mouse thymocytes. Analysis by three-color flow cytometry
29. Characterization of the murine antigenic determinant designated L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen reactivity
30. − thymocytes
31. Kinetics of mature T-cell development in the thymus
32. Immunoglobulin class switching: molecular and cellular analysis
33. Lymphokine control of in vivo immunoglobulin isotype selection
34. Molecular and cellular events of T cell development
35. A novel population of T-cell receptor αβ-bearing thymocytes which predominantly expresses a single Vβ gene family
36. Neonatal suppression with anti-la antibody. I. Suppression of murine B lymphocyte development
37. Unexpected expression of a unique mixed-isotype class II MHC molecule by transfected L-cells
38. Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function
39. Transgenesis by means of blastocyst-derived embryonic stem cell lines
40. Novel pathways of antigen presentation for the maintenance of memory
41. Combined immunodeficiency with defective expression in MHC class II genes
42. Lymphoid tissue architecture: experimental analysis of the origin and distribution of T and B cells
43. Development of murine B cell subpopulations
44. T-cell receptor gene in autoimmune mice: T-cell subsets have unexpected T-cell receptor gene programs
45. The antigen-specific major histocompatibility complex-restricted receptor on T cells
46. The lymph follicle: a hard nut to crack
47. Conventional and Ly-1 B-cell lineages in normal and μ transgenic mice
48. T-cell-mediated regulation: help and suppression
49. −thymocytes
50. − thymocytes
51. A novel class II MHC molecule with unusual tissue distribution
52. MHC-like molecules in some nonmammalian vertebrates can be detected by some crossreactive xenoantisera
53. MHC-like molecules in some nonmammalian vertebrates can be detected by some crossreactive monoclonal antibodies
54. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
55. d gene-introduced C57BL/6 transgenic mice
56. + thymocytes
57. Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-la antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells
58. + lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function
59. Characterization of a monoclonal antibody which detects all murine up T cell receptors
60. Immune status of a μ, κ transgenic mouse line. Deficient response to bacterially related antigens
61. The assignment of chain specificities for anti-la monoclonal antibodies using L cell transfectants
62. Sequence of gene and cDNA encoding murine major histocompatibility complex class II gene Apt
63. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens
64. + T cells by class II major histocompatibility complex molecules
65. Correcting an immune-response deficiency by creating Eα gene transgenic mice
66. Qualitative and quantitative heterogeneity in Pgp-1 expression among murine thymocytes
67. + T cells
68. Mouse strain variation in Ly-24 (Pgp-1) expression by peripheral T cells and thymocytes: implications for T cell differentiation
69. − cytotoxic T lymphocytes specific for class I H-2 antigens are activated in primary mixed lymphocyte reactions
70. − cytotoxic T lymphocytes
71. d genes into L cells results in the surface expression of a functional mixed-isotype la molecule
72. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
73. Several mechanisms can account for defective Ea gene expression in different mouse haplotypes
74. Structure and specificity of a class II MHC alloreactive γδ T cell receptor
75. Characterization of a CD4 (L3T4)-positive cytotoxic T cell clone that is restricted by class I MHC antigen on FBL-3 tumor cell
76. − cells repopulating thymus in radiation bone marrow chimeras
77. d class II molecules
78. Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes
79. The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene
80. −lymphocytes of Ipr mice: comparison with normal immature thymocytes
81. Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain
82. A role for IFN-γ and NK cells in immune responses to T cell-regulated antigens types 1 and 2
83. + accessory cells are required for the in vitro generation of thymic independent type 2 antibody responses to polysaccharide antigens
84. + cells by CD4
85. Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus
86. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and la antigens
87. An intermediate cell in thymocyte differentiation that expresses CD8 but not CD4 antigen
88. Clonal analysis of B- and T-cell responses to la antigens
89. +) subsets among anti-la cytolytic T cell clones
90. k molecules
91. Junctional sequences influence the specificity of γ/δ T cell receptors
92. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
93. Mouse lymph node germinal centers contain a selected subset of T cells: the helper phenotype
94. Intracellular competition for component chains determines class II MHC cell surface phenotype
95. Predominant role of amino-terminal sequences in dictating efficiency of class II major histocompatibility complex a(3 dimer expression
96. The thymus in “bare lymphocyte” syndrome: significance of expression of major histocompatibility complex antigens on thymic epithelial cells in intrathymic T-cell maturation
97. The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens
98. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
99. Mixed isotype class II antigen expression
100. Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens
101. Follicular dendritic cells as accessory cells
102. A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex
103. d haplotype
104. Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphnode cells
105. Monoclonal antibodies to stromal cell types of the mouse thymus
106. +) phenotype in B cell chronic lymphocytic leukemia
107. + cells with natural killer cell-related features. Divergence from typical T helper cells
108. + germinal-center cells with the T helpercell phenotype and granular lymphocyte morphology
109. Qa-2 expression in the adult murine thymus. A unique marker for a mature thymic subset
110. The developmental biology of T lymphocytes
111. Developmental biology of T cells in T cellreceptor transgenic mice
112. Multiple mechanisms regulate the expression of murine immune response genes
113. Manipulation of T-cell responses with monoclonal antibodies
114. − thymocytes that express the T cell receptor may have previously expressed CD8
115. Role of CD4 in thymocyte selection and maturation