Mitochondrial oxidative phosphorylation defects in parkinson's disease

Annals of Neurology

Volumn 30, Issue 3, 1991, Pages 332-339

  Shoffner, John M ^a   Watts, Ray L ^a   Juncos, Jorge L ^a   Torroni, Antonio ^a   Wallace, Douglas C ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DOPAMINE; FREE RADICAL; SUPEROXIDE DISMUTASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MUSCLE BIOPSY; PARKINSON DISEASE; PRIORITY JOURNAL;

ADULT; AGED; AGING; BIOPSY; CHILD; DNA, MITOCHONDRIAL; FEMALE; GLYCOGEN; HUMAN; LIPIDS; MALE; MIDDLE AGE; MITOCHONDRIA, MUSCLE; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PARKINSON DISEASE; POLYMORPHISM (GENETICS); SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026091344     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.410300304     Document Type: Article

References (51)

1. Biochemical events in the development of Parkinsonism induced by 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine
2. Chronic parkinsonism in humans due to a product of meperidine‐analog synthesis
3. Inhibition of NADH‐linked oxidation in brain mitochondria by 1‐methyl‐4‐phenyl‐pyridine, a metabolite of the neurotoxin, 1 methy‐4‐phenyl‐1,2,5,6,‐tetrahydropyridine
4. Carbon monoxide
5. Cyanideinduced parkinsonism: a clinicopathologic report
6. Cyanide‐induced parkinsonism: clinical, MRI, and 6‐fluorodopa PET studies
7. Abnormalities of the electron transport chain in idiopathic Parkinson's disease
8. Mitochondrial function in Parkinson's disease
9. Mitochondrial complex I deficiency in Parkinson's disease
10. Subacute necrotizing encephalomyelopathy: a review and a study of two families
11. Subacute necrotizing encephalomyelopathy (Leigh's disease): a consideration of clinical features and etiology
12. Leber's disease and dystonia: a mitochondrial disease
13. Kearns‐Sayre syndrome with hypoparathyroidism
14. MELAS syndrome involving a mother and two children
15. Computed tomography and angiography in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke‐like episodes); report of 3 cases
16. Heterogeneous phenotypes of mitochondrial encephalomyopathy in a single kindred
17. CT and MR of MELAS sundrome
18. Deficiency of subunits of complex I and mitochondrial encephalomyopathy
19. Oxidative phosphorylation diseases: disorders of two genomes
20. Sequence and organization of the human mitochondrial genome
21. Evaluation of procedures for assaying oxidative phosphorylation enzyme activities in mitochondrial muscle biopsies
22. Parkinsonism: onset, progression, and mortality
23. Familial mitochondrial encephalomyopathy (MERRF): genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease
24. Variable genotype of Leber's hereditary optic neuropathy patients
25. Lys mutation
26. Morgen‐Hughes JA. A new mitochondrial disease associated with mitochondrial DNA heteroplasmy
27. Decline in skeletal muscle mitochondrial respiratory function: Possible factor in ageing
28. Reduction in maximal oxygen uptake with age
29. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy
30. Radiation of human mitochondrial DNA types analyzed by restriction endonuclease cleavage patterns
31. Voljavec As, et al. Spontaneous Kearns‐Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip‐replication model and metabolic therapy
32. Structure and assembly of cytochrome c oxidase
33. What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15‐ to 83‐year‐old men
34. Histochemical and metabolic charcteristics of human skeletal muscle in relation to age
35. Cytrochrome c oxidase deficiency in Leigh syndrome
36. Deficiency of the reduced nicotinamide adenine dinucleotide dehydrogenase component of complex I of mitochondrial electron transport: fatal infantile lactic acidosis and hypermetabolism with skeletalcardiac myopathy and encephalopathy
37. Clinical presentation of mitochondrial respiratory chain defects in NADH‐coenzyme Q reductase and cytochrome c oxidase: clues to the pathogenesis of Leigh disease
38. Intravenous pyruvate loading test in Leigh syndrome
39. Influence of mitochondrial radical formation of energy‐linked respiration
40. Oxygen radical release in mitochondria: influence of age
41. 2 by NADH‐ubiquinone reductase and ubiquinol‐cytochrome c reductase from beef heart mitochondria
42. On probe and ubiquinone interactions in mitochondrial membranes
43. Energy couplig mechanisms in mitochondria: kinetic, spectroscopic, and thermodynamic properties of an energy‐transducing form of cytochrome b
44. Influence of age and time interval between death and autopsy on dopamine and 3‐methoxytyramine levels in human basal ganglia
45. Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain
46. Ageing and extrapyramidal function
47. On the origin and significance of neuromelanin
48. Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease