Structure-Activity Relationship of Quinazolinedione Inhibitors of Calcium-Independent Phosphodiesterase

Journal of Medicinal Chemistry

Volumn 34, Issue 2, 1991, Pages 624-628

  Lowe, John A ^a   Archer, Robert L ^a   Chapin, Douglas S ^a   Cheng, John B ^a   Helweg, David ^a   Johnson, Jonathan L ^a   Koe, B Kenneth ^a   Lebel, Lorraine A ^a   Moore, Peter F ^a   Nielsen, Jann A ^a   Russo, Lorena L ^a   Shirley, John T ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 QUINAZOLINEDIONE DERIVATIVE; ENZYME INHIBITOR; NITRAQUAZONE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; QUINAZOLINE DERIVATIVE; ROLIPRAM; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BRAIN; DEPRESSION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; GUINEA PIG; INFLAMMATION; LUNG; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0026073884     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00106a024     Document Type: Article

References (18)

1. Reeves, M. L.; Leigh, B. K.; England, P. J. Biochem. J. 1987, 241, 535.
2. Eckmann, F.; Fichte, K.; Meya, U.; Sastre-y-Hernandez, M. Curr. Ther. Res. 1988, 43, 291.
3. Koe, B. K.; Lebel, L. A.; Nielsen, J. A.; Russo, L. L.; Saccomano, N. A.; Vinick, F. J.; Williams, I. H. Drug. Dev. Res., in press.
4. Glaser, T.; Traber, J. Agents Actions 1984, 15, 341.
5. Russo, L. L.; Lebel, L. A.; Koe, B. K. Soc. Neurosci. Abstr. 1987, 13, 903.
6. Durant, G. J. Chem. Ind. 1965, 1428.
7. Lehmstedt, K.; Schrader, K. Chem. Ber. 1937, 70, 838.
8. Ullman, F. Liebigs Ann. Chem. 1907, 355, 330.
9. Shioiri, T.; Ninomiya, K.; Yamada, S. J. Am. Chem. Soc. 1972, 94, 6203.
10. Davis, C. Biochim. Biophys. Acta 1984, 797, 354.
11. Donaldson, J.; Brown, A. M.; Hill, S. J. Biochem. Pharmacol. 1988, 37, 715.
12. Hebenstreit, G. F.; Fellerer, K.; Fichte, K.; Geyer, N. Pharmacopsychiatry 1989, 22, 156.
13. Davis, C. W.; Daly, J. W. J. Cycl. Nucleotide Res. 1979, 5, 65.
14. Askew, B. M. Life Sci. 1963, 4, 725.
15. Koe, B. K. J. Pharmacol. Exp. Ther. 1983, 226, 686.
16. Porsolt, R. Arch. Int. Pharmacodyn. 1977, 229, 327.
17. Wallach, M. B.; Hedley, L. R. Psychopharmacology 1979, 3, 35.
18. Winter, C. A.; Risley, E. A.; Nuss, G. W. Proc. Soc. Exp. Biol. 1963, 111, 544.