Assessment of the acute acrylonitrile-induced neurotoxicity in rats

Neurotoxicology and Teratology

Volumn 13, Issue 5, 1991, Pages 499-502

  Ghanayem, Burhan I ^a   Farooqui, Mohammed Y H ^a   Elshabrawy, Osama ^a   Mumtaz, M Moizuddin ^a   Ahmed, Ahmed E ^a  

^a Department of Pathology Pharmacology and Toxicology The University Texas Medical Branch ^*  (United States)

Author keywords

Acrylonitrile; Cholinomimetic; Chromodacryorrhea; Lacrimation; Neurotoxicity; Salivation

Indexed keywords

ACRYLONITRILE; ATROPINE;

ANIMAL EXPERIMENT; ARTICLE; CHOLINERGIC SYSTEM; LACRIMATION; MALE; NEUROTOXICITY; NONHUMAN; RAT; SALIVATION;

ACRYLONITRILE; ADMINISTRATION, ORAL; ANIMAL; ATROPINE; ATROPINE DERIVATIVES; COMPARATIVE STUDY; DIARRHEA; DIURESIS; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, SUBCUTANEOUS; MALE; NEUROTOXINS; PARASYMPATHOMIMETICS; RATS; RATS, INBRED STRAINS; SALIVA; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA;

EID: 0026070308     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/0892-0362(91)90056-3     Document Type: Article

References (23)

1. Studies on the mechanism of acrylonitrile neurotoxicity
2. Acrylonitrile in vivo metabolism in rats and mice
3. Influence of sulfhydryls reagents and heavy metals on the functional state of the muscarinic acetylcholine receptors in rat brain
4. Primary brain tumors in Fischer 344 rats chronically exposed to acrylonitrile in drinking water
5. Toxicity of acrylonitrile (vinyl cyanide) I. A study of the acute toxicity
6. Regulation of muscarinic receptor binding of guanine nucleotides and N-ethylmaleimide
7. Effect of acute acrylonitrile exposure on metrazol induced seizures in the rat
8. Molecular interactions of acrylonitrile and potassium cyanide with rat blood
9. +-ATPase in rat erythrocytes exposed to acrylonitrile
10. Metabolism of acrylonitrile by isolated rat hepatocytes
11. 14C acrylonitrile in rats
12. Acrylonitrile-induced gastric mucosal necrosis: Role of gastric glutathione
13. Acrylonitrile-induced gastrointestinal hemorrhage and effects of metabolism modulation in rats
14. In vitro metabolism of acrylonitrile to 2-cyanoethylene oxide, reaction with glutathione and irreversible binding to proteins and nucleic acids
15. Toxicity of acrylonitrile metabolism mode of action and therapy
16. The importance of thiol and disulfide groups in agonist and antagonist binding to the muscarinic receptor
17. The peripheral and central anticholinergic properties of benzetimide (R4929) and other atropine like drugs as measured in a new antipilocarpine test in rats
18. A bioassay for muscarine activity and its detection in certain inocybe
19. Carcinogenicity bioassays on rats of acrylonitrile administered by inhalation and by ingestion
20. The toxicity of acrylonitrile
21. Results of a chronic toxicity and oncogenicity study in rat following 24 months of acrylonitrile inhalation exposure
22. Morphologische untersuchunger zur wirkung von acrylonitrile in subchronischen Intoxicationsversuch bei der weiben ratte
23. Styrene and acrylonitrile induced depression of hepatic nonprotein sulfhydryl content in various rodent species