The ovariectomized rat model of postmenopausal bone loss

Bone and Mineral

Volumn 15, Issue 3, 1991, Pages 175-191

  Kalu, Dike N ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Bone loss; Ovarian hormone deficiency; Rat model

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CALCITONIN; ESTROGEN; PARATHYROID HORMONE; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BONE ATROPHY; BONE MASS; CALCIUM ABSORPTION; EXERCISE; FEMALE; NONHUMAN; OVARIECTOMY; POSTMENOPAUSE; PRIORITY JOURNAL; RAT; REVIEW;

AGING; ANIMAL; BUSERELIN; COMPARATIVE STUDY; DISEASE MODELS, ANIMAL; FEMALE; HUMAN; OSTEOPOROSIS, POSTMENOPAUSAL; OVARIECTOMY; RATS; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA;

EID: 0026068145     PISSN: 01696009     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-6009(91)90124-I     Document Type: Review

References (98)

1. Human aging: usual and successful
2. Osteoporosis Concensus Conference
3. The pathogenesis of osteoporosis
4. Clinical spectrum
5. Postmenopausal osteoporosis its clinical features
6. Introduction: What is a model
7. Mineral metabolism
8. Diagnosis and treatment of osteoporosis
9. The biology of aging, with particular reference to the musculoskeletal system
10. Bone loss and biochemical indices of bone remodeling in surgically induced postmenopausal women
11. Early menopausal changes in bone mass and sex steroids
12. Spinal mineral loss in oophorectomized women
13. Menopausal changes in bone remodeling
14. Effects of artificial menopause on plasma and urine calcium and phosphate
15. Increase in serum bone y-car☐yglutanic acid protein with aging in women. Implications for the mechanism of age-related bone loss
16. Plasma bone gla protein concentrations in healthy adults. Dependence on sex, age, and glomerular filtration
17. Alterations in skeletal metabolism following oophorectomy
18. Menopausal changes in calcium balance performance
19. The effect of age on serum immunoreactive parathyroid hormone in normal and osteoporotic women
20. Radioimmunoassay of serum parathyroid hormone in postmenopausal osteoporosis
21. Parathyroid function in primary osteoporosis
22. Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients
23. 2D levels in postmenopausal osteoporosis
24. Serum levels of 25-hydroxyvitamin D in postmenopausal osteoporosis
25. Deficiency of calcitonin in age related osteoporosis
26. Basal plasma immunoreactive calcitonin in postmenopausal osteoporosis
27. Calcitonin secretion in postmenopausal osteoporosis
28. Deficient calcitonin response to calcium infusion in postmenopausal osteoporosis
29. The glycosaminoglycans of compact bone tissue in experimental osteoporosis. Induced by combined oophorectomy and prednisolone treatment or prolonged calcium restriction in one year old rats
30. The effect of combined oophorectomy and prednisolone administration on the skeletal tissue and calcium retention in one year old rats
31. Changes in skeletal mass and fragility with castration in the rat; a model of osteoporosis
32. Osteoporosis after oophorectomy in the mature female rat and the effect of estrogen and/or progesterone replacement therapy in its prevention
33. Effect of oophorectomy and calcium deprivation on bone mass in the rat
34. The effects of ovarian sex steroids on bone minral status in oophorectomized rat in the human
35. Kinetic parameters of calcium metabolism and femur morphometry in rats II Influence of ovariectomy and dietary calcium
36. 3 on osteoporosis in rats induced by oophorectomy
37. Effect of long-term estrogen administration on bone metabolism in the female rat
38. Failure of DHEA to modulate ovariectomy induced osteopenia in rats
39. Evaluation of the role of calcitonin deficiency in ovariectomy-induced osteopenia
40. Evaluation of the pathogenesis of skeletal changes in ovariectomized rats
41. Cancellous bone resorption in the proximal ilium of the ovariectomized rat
42. Long-term effects of ovariectomy and aging on the rat skeleton
43. The aged rat model of ovarian hormone deficiency bone loss
44. Characteristics of an ovariectomized osteopenic rat model
45. Effects of progesterone on postovariectomy bone loss in aged rats
46. Human parathyroid hormone-(1–34) prevents bone loss and augments bone formation in sexually mature ovariectomized rats
47. 2 on production of new cancellous bone in the axial skeleton of ovariectomized rats
48. 2 enhances cortical bone mass and activates intracortical bone remodeling in intact and ovariectomized female rats
49. Effect of naproxen on cancellous bone in ovariectomized rats
50. Nondestructive measurement of bone mineral in femurs from ovariectomized rats
51. Contrasting effects of parathyroid hormone (PTH) and human recombinant insulin-like growth factor 1 (IGF-1) on bone in an aged ovariectomized (OVX) rat model of postmenopausal osteoporosis
52. Chronologic changes in sex steroid, gonadotropin and prolactin secretion in aging female rats displaying different reproductive states
53. Life span study for SPF Fischer 344 male rats fed ad libitum or restricted diets: longevity, growth, lean body mass and disease
54. 3 in the development of osteopenia in oophorectomized rats
55. Modulation of ovariectomy-related bone loss by parathyroid hormone in rats
56. The effects of ovariectomy and 17β-estradiol on cortical bone histomorphometry in growing rats
57. Serum bone gla protein and the vitamin D endocrine system in the oophorectomized rat
58. Hyperostosis induced by the bisphophonate (2-PEBP) in the oophorectomized rat
59. The effects of ovariectomy and 17β-estradiol on cortical bone histomorphometry in growing rats
60. Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats
61. Skeletal response of ovariectomized rats to low and high doses of 17β-estradiol
62. 3H-tetracycline), bone formatin and changes in bone mass at the organ level
63. LHRH analogues and bone loss
64. A new way to induce estrogen deficiency osteopenia in the rat: comparison of the effects of surgical ovariectomy and administration of LHRH agonist buserelin on bone resorption and composition
65. Bone loss and aging
66. Clinical significance and pathogenesis of osteoporosis
67. Early postmenopausal bone loss is not associated with a decrease in circulating levels of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, or vitamin D binding proteins
68. Effect of body weight on osteopenia in ovariectomized rats
69. Height and weight in symptomatic postmenopausal osteoporosis
70. Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats
71. Sex steroids in the pathogenesis and prevention of osteoporosis
72. Effect of intermittent cyclic etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis
73. Endocrine and pharmacological suppressors of bone turnover protect against osteopenia in ovariectomized rats
74. Increase of whole body calcium and skeletal mass in normal and osteoporotic adult rats treated with parathyroid hormone
75. Effect of human parathyroid hormone (PTH[1–34]) on experimental osteopenia of rats induced by ovariectomy
76. Anabolic effect of human parathyroid fragment on trabecular bone in involutional osteoporosis: a multicentre trial
77. Calcitriol corrects bone loss induced by oophorectomy in rats
78. Effect of eel calcitonin on the prevention of osteoporosis induced by combination of immobilization and ovariectomy in the rat
79. Longterm calcitonin therapy in postmenopausal osteoporosis
80. Calcitonin for prevention of postmenopausal bone loss
81. Effects of tamoxifen on spinal bone density in women with breast cancer
82. A comparative study of the actions of tamoxifen, estrogen and progesterone in the ovariectomized rat
83. Morphometry and calcium contents in appendicular and axial bones of exercised ovariectomized rats
84. Endurance training and bone loss in calcium deficient and ovariectomized rats
85. Increased trabecular bone density due to bone-loading exercises in postmenopausal osteoporotic women
86. Growth disease and aging in the rat
87. Aging an dietary modulation of rat skeleton and parathyroid hormone
88. Modulation of age-related hyperparathyroidism and senile bone loss in Fischer rats by soy protein and food restriction
89. Evidence of sequential remodeling in rat trabecular bone: morphology, dynamic histomorphometry, and changes during skeletal maturation
90. Dynamic histomorphometry of alveolar bone remodeling in adult rat
91. Cellular kinetics of the bone remodeling sequence in the rat
92. A quantitative histologic analysis of the growing long bone metaphysis
93. Bone studies II. An experimental study of the Haversian-type vascular channels
94. Strength and size of bone in relation to calcium intake
95. The effects of ovarian steroids on food and water intake and body weight in the female rat