The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

Cell

Volumn 64, Issue 5, 1991, Pages 891-901

  Irving, Bryan A ^a   Weiss, Arthur ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ARTICLE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTIGENS, CD3; ANTIGENS, CD8; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CALCIUM; CELL LINE; CHIMERA; CYTOPLASM; HUMAN; INOSITOL PHOSPHATES; INTERLEUKIN-2; MACROMOLECULAR SYSTEMS; PHOSPHOTYROSINE; POLYMERASE CHAIN REACTION; PROTEIN-TYROSINE KINASE; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; TYROSINE;

EID: 0026064305     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(91)90314-O     Document Type: Article

References (58)

1. Lysine 271 in the transmembrane domain of the T-cell antigen receptor β chain is necessary for its assembly with the CD3 complex but not for α/β dimerization
2. CD3-negative natural killer cells express ζ TCR as part of a novel molecular complex
3. Genetic and mutational analysis of the T cell antigen receptor
4. Disulfide linkage of the ζ and η chains of the T cell receptor
5. The T cell antigen receptor ζ chain is tyrosine phosphorylated upon activation
6. Membrane phospho-inositide-activated signals in mast cells and basophils
7. Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release
8. Transfection of genes encoding the T cell receptor-associated CD3 complex into COS cells results in assembly of the macromolecular structure
9. Inositol phosphates and cell signalling
10. The biologic roles of CD2, CD4 and CD8 in T-cell activation
11. Assembly and function of the T cell antigen receptor
12. The CD2 and LFA-3 activates T cells but depends on the expression and function of the antigen receptor
13. Subunit interactions within the T-cell antigen receptor: clues from the study of partial complexes
14. Pre-glogi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly
15. The T cell receptor/CD3 complex: a dynamic protein ensemble
16. Contingent genetic regulatory events in T lymphocyte activation
17. Stimulation of the phosphatidylinositol pathway can induce T-cell activation
18. Structural mutations of the T cell receptor ζ chain and its role in T cell activation
19. The structure and signalling functions of the invariant T cell receptor components
20. Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor
21. New clues about T-cell antigen receptor complex function
22. +2 indicators with greatly improved fluorescent properties
23. T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates
24. Transmembrane signalling by the T cell antigen receptor: perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores
25. Molecular cloning of the CD3η subunit identifies a CD3ζ-related product in thymusderived cells
26. Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation
27. Inhibition of tyrosine phosphorylation prevents T cell receptor-mediated signal transduction
28. Antibody-cell interactions: Fc receptors
29. Architectural editing: determining the fate of newly synthesized membrane proteins
30. The implications of subunit interactions for the structure of the T cell receptor-CD3 complex
31. Co-association of CD3ζ with a receptor (CD16) for IgG Fc on human natural killer cells
32. The structure of the CD4 and CD8 genes
33. The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes
34. Transmembrane helical interactions and the assembly of the T cell receptor complex
35. T cell CD3-ζη heterodimer expression and coupling to phosphoinositide hydrolysis
36. Activation-driven programmed cell death and T cell receptor ζη expression
37. The lysine residue in the membrane-spanning domain of the β chain is necessary for cell surface expression of the T cell antigen receptor
38. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
39. Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction
40. T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation
41. Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer
42. Biochemical characterization of the η chain of the T-cell receptor: a unique subunit related to ζ
43. Family of disulphide-linked dimers containing ζ and η chains of the T-cell receptor and the γ chain of Fc receptors
44. Multiple kinases and signal transduction
45. Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor
46. Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor
47. DNA sequencing with chain-terminating inhibitors
48. Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein
49. Interleukin-2: inception, impact, and implications
50. The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes
51. Failure to synthesize the T cell CD3-ζ chain: structure and function of a partial T cell receptor complex
52. Thy-1 and Ly-6 mediated lymphokine production and growth inhibition of a T cell hybridoma require co-expression of the T cell antigen receptor complex
53. Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering: requirement for receptor crosslinking, prolonged elevation of intracellular [Ca2+] and stimulation of protein kinase C
54. Cell surface molecules and early events involved in human T lymphocyte activation
55. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line
56. Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium
57. Molecular cloning and chromosomal localization of the human T-cell receptor ζ chain: distinction from the molecular CD3 complex
58. Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies