Analysis of the steric strain in the polypeptide backbone of protein molecules

Proteins: Structure, Function, and Bioinformatics

Volumn 11, Issue 3, 1991, Pages 223-229

  Herzberg, Osnat ^a   Moult, John ^a  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

cis peptides; crystal structure; dihedral angles; protein active sites; protein structure

Indexed keywords

CARBOXYPEPTIDASE; CONCANAVALIN A; PENICILLINASE; SUBTILISIN;

ARTICLE; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN STRUCTURE;

BINDING SITES; CRYSTALLOGRAPHY; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEINS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026055156     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.340110307     Document Type: Article

References (38)

1. Stability of protein structure and hydrophobic interaction
2. Common features of protein unfolding and dissolvation of hydrophobic compounds
3. The barrier to internal rotation in amides. IV. N,N‐Dimethylamides; substituents and solvent effects
4. An explanation for the rare occurrence of cis peptide units in proteins and polypeptides
5. Stereochemical criteria for polypeptide and protein chain conformation
6. Crystal structure of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 Å resolution. I. General features and binding of methotrexate
7. Crystal structure of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 Å resolution. II. Environment of bound NADPH and implications for catalysis
8. Zinc environment and cis peptide bonds in carboxypeptidase A at 1.75 Å resolution
9. Refined crystal structure of carboxypeptidase A at 1.54 Å resolution
10. Manganese and calcium binding sites of concanavalin A
11. The high resolution x‐ray crystal structure of the complex formed between subtilisin Carlsberg and eglin C, an elastase inhibitor from the leech Hirudo medicinalis. Structural analysis, subtilisin structure and interface geometry
12. Structural comparison of two serine proteinase–protein inhibitor complexes: Eglin‐C–subtilisin Carlsberg and CI‐2–subtilisin Novo
13. Bacterial resistance to β‐lactam antibiotics: Crystal structure of β‐lactamase from Staphylococcus aureus PC1 at 2.5 Å resolution
14. Refined crystal structure of β‐lactamase from staphylococcus aureus PC1 at 2.0 Å resolution
15. Stereochemically restrained crystallographic least squares refinement of macromolecular structures.
16. Refinement of large structures by simultaneous minimization of energy and R factor
17. An efficient general purpose least‐squares refinement program for macromolecular structures
18. New least squares refinement technique based on a fast Fourier transform algorithm
19. Quantum theory of the structure and bonding in proteins. Part 8: the alanine dipeptide
20. Conformational transition and geometry differences between low‐energy conformers of N‐acetyl‐N‐methyl alanine amide: An ab initio study at the 4–21G level with gradient relaxed geometries
21. Systematic ab initio gradient calculation of molecular geometries, force constants, and dipole moment derivatives
22. Compact effective potentials and efficient shared‐exponent basis sets for the first‐ and second‐row atoms
23. Single amino‐acid substitution blocks a late step in the folding of β‐lactamase from Staphylococcus aureus
24. Protein structure refinement. Streptomyces griseus serine protease A at 1.8 Å resolution
25. Structure of actinidin after refinement at 1.7 Å resolution
26. Theoretical studies of enzymatic reactions: Dialectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme
27. An algorithm for determining the conformation of polypeptide segments in proteins by systematic search
28. Crystal structure of a lysozyme‐tetrasaccharide lactone complex
29. The structure of the saccharide‐binding site of concanavalin A
30. Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 Å resolution
31. Refined structure of α‐lytic protease at 1.7 Å resolution. Analysis of hydrogen bonding and solvent structure
32. Structure of the complex of Streptomyces griseus protease B and the third domain of turkey ovomucoid inhibitor at 1.8 Å resolution
33. Rat submaxillary gland serine protease, tonin: Structure solution and refinement at 1.8 Å resolution
34. Refined structure of glutathione reductase at 1.54 Å resolution
35. Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen‐binding fragment at 3.0 Å and 1.9 Å resolution
36. The structure of 2Zn pig insulin crystals at 1.5 Å resolution
37. The protein data bank: A computer‐based archival file for macromolecular structures