Increased NMDA responses and dendritic degeneration in human epileptic hippocampal neurons in slices

Neuroscience Letters

Volumn 132, Issue 2, 1991, Pages 212-216

  Isokawa, Masako ^a   Levesque, Michel F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Dendritic spine loss; Excitotoxicity; Intractable epilepsy; Long lasting excitatory postsynaptic potential

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID;

ARTICLE; DEGENERATION; DENDRITE; EPILEPSY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; NORMAL HUMAN; PRIORITY JOURNAL;

ADOLESCENT; ADULT; DENDRITES; ELECTRIC STIMULATION; EPILEPSY; HIPPOCAMPUS; HUMAN; N-METHYLASPARTATE; NERVE DEGENERATION; NEURONS; SUPPORT, U.S. GOV'T, P.H.S.; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 0026046023     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(91)90304-C     Document Type: Article

References (22)

1. Electrophysiological properties and synaptic responses in the deep layers of the human epileptogenic neocortex in vitro
2. Influence of cortico-striatal afferents on striatal kainic acid neurotoxicity
3. Structural substrates of seizure foci in the human temporal lobe
4. NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection
5. Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy
6. Neurotransmitter release in the human hippocampus in vivo: physiological and pharmacological studies of complex partial epilepsy
7. Changes in excitability of CA1 pyramidal neurons in slices prepared from AlC13-treated rabbits
8. Seizure-like activity and cellular damage in rat hippocampal neurons in cell culture
9. Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy
10. NMDA receptor-mediated excitability in dendritically deformed dentate granule cells in pilocarpine-treated rats
11. Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission
12. 3H]glutamate in rat brain tissue
13. Prolonged epileptic seizures in primates
14. Epilepsy and neuron loss in the hippocampus
15. Excitotoxic mechanisms of epileptic brain damage
16. Spine loss and regrowth in hippocampus following deafferentation
17. Structural substrates of epilepsy
18. The hippocampal-dentate complex in temporal lobe epilepsy
19. An NMDA-mediated component of excitatory synaptic input to dentate granule cells in epileptic human hippocampus studied in vitro
20. Morphology of experimental epileptic focus
21. Synaptic transmission in human neocortex removed for treatment of intractable epilepsy in children