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Interferon Gamma-activated Human Moncytes Down-regulate Transferrin Receptors and Inhibit the Intracellular Multiplication of Legionella pneumophila by Limiting the Availability of Iron
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Induction of Nitrite/Nitrate Synthesis in Murine Macrophages by BCG Infection, Lymphokines, or Interferon-y
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Editorial. Does Endothelium-Derived Nitric Oxide Have a Role in Cytokine-Induced Hypotension?
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Localization of Nitric Oxide Synthase Indicating a Major Neural Role for Nitric Oxide
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Bredt1
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L-citrulline Production from L-arginine by Macrophage Nitric Oxide Synthase: The Ureido Oxygen Derives from Dioxygen
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of outstanding interest, Reports basic biochemical features of NO generation in macrophages.
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(1990)
J Biol Chem
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Kwon1
Nathan2
Gilker3
Griffith4
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21
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0024549389
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Activated Murine Macrophages Secrete a Metabolite of Arginine With the Bioactivity of Endothelium-Derived Relaxing Factor and the Chemical Reactivity of Nitric Oxide
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of interest, One of the earliest reports of macrophage NO production, see also [18,20], this paper is noteworthy in the present context for its direct demonstration of extracellular release of RNI from macrophages in a cascade perfusion system, and for showing that macrophage-derived RNI can interact with a specific microbial enzyme.
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(1989)
J Exp Med
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Stuehr1
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Levi4
Nathan5
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23
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0025017079
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Metabolic Fate of L-arginine in Relation to Microbiostatic Capability of Murine Macrophages
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of interest, This is the only systematic study of L-arginine metabolism in activated murine macrophages.
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(1990)
J Clin Invest
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Granger1
Hibbs2
Perfect3
Durack4
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24
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84908812999
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Mammalian Synthesis of Nitric Oxide
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of interest, A comprehensive review of current understanding of the biochemistry of NO generation by mammalian cells. in press
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(1991)
Adv Enzymol
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Stuehr1
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25
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0024388901
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Macrophage Oxidation of L-arginine to Nitric Oxide, Nitrite, and Nitrate: Tetrahydrobiopterin is Required as a Cofactor
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of interest, Demonstrates basic biochemical features of NO generation in macrophages
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(1989)
J Biol Chem
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Tayeh1
Marietta2
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26
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Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages
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of interest, Basic biochemical features of NO generation in macrophages.
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J Biol Chem
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28
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84908812998
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Inhibition of Nitric Oxide Synthase by Diphenyleneiodonium and its Analogs
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of special interest, Introduces an alternative to NMMA as an inhibitor of NO synthase, distinguished by its distinct mechanism of action, greater potency, and it reversibility. in press
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(1991)
FASEB J
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Stuehr1
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29
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0024584020
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Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
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of interest, This report deals with the metabolic pattern of target cell injury caused by NO (see also [20]). In addition, it describes the use of NO scavengers as well as inhibitors of NO production to define the role of RNI in macrophage anti-tumor activity, and demonstrates the cytostatic potential of nitrite at acid pH.
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L-arginine-dependent Reactive Nitrogen Intermediates as Mediators of Tumor Cell Killing by Activated Macrophages
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Cytolytic Mechanisms of Activated Macrophages: Tumor Necrosis Factor and L-arginine-Dependent Mechanisms Act Synergistically as the Major Cytolytic Mechanisms of Activated Macrophages
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Release of Reactive Nitrogen Intermediates and Reactive Oxygen Intermediates From Mouse Peritoneal Macrophages: Comparison of Activating Cytokines and Evidence for Independent Production
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Interferon-7 and Tumor Necrosis Factor Induce the L-arginine-dependent Cytotoxic Effector Mechanism in Murine Macrophages
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Differentiation of Murine Macrophages to Express Nonspecific Cytotoxicity for Tumor Cells Results in L-arginine-dependent Inhibition of Mitochondrial Iron-sulfur Enzymes in the Macrophage Effector Cells
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36
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Interferon y and Lymphotoxin or Tumor Necrosis Factor Act Synergistically to Induce Macrophage Killing of Tumor Cells and Schistosomula of Schistosoma mansoni
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Esparza1
Mannel2
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37
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Tumor necrosis Factor-a in Combination with Interferon-y, but not With Interleukin-4 Activates Murine Macrophages for Elim ination of Leishmania major Amastigotes
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Eur J Immunol
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38
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0025050464
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Cellular Mechanisms of Nonspecific Immunity to Intracellular Infection: Cytokine-Induced Synthesis of Toxic Nitrogen Oxides from L-arginine by Macrophages and Hepatocytes
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of interest, Reviews the authors' own evidence for the involvement of RNI in antileishmanial activity of macrophages and presents preliminary evidence for a role in hepatocytes.
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(1990)
Immunol Lett
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Green1
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39
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0025311615
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Macrophage Deactivation Factor and Transforming Growth Factors-β-1, -2, and -3 Inhibit Induction of Macrophage Nitrogen Oxide Synthesis by Interferon-λ
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of interest, The first evidence that macrophage RNI production is not susceptible to inhibition by cytokines.
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(1990)
J Immunol
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Ding1
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42
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0024821351
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Macrophage Cytotoxicity Against Schistosomula of Schistosoma mansoni Involves Argininedependent Production of Reactive Nitrogen Intermediates
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of outstanding interest, The first direct evidence, using NMMA, for the involvement of RNI in antimicrobial activity of macrophages.
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(1989)
J Immunol
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James1
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43
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0023568490
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On the Interactions Between Macrophages and the Developmental Stages of Schistosoma mansoni the Cytotoxic Mechanism Involved in Macrophage-mediated Killing of Schistosomula in vitro
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Maliwr1
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44
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0025191159
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Activated Macrophages Destroy Intracellular Leishmania major Amastigotes by an L-arginine Dependent Killing Mechanism
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of interest, Presents evidence for the involvement of RNI in antimicrobial activity of macrophages.
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Macrophage Killing of Leishmania Parasite in vivo is Mediated by Nitric Oxide from L-arginine
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of outstanding interest, Presents evidence for the involvement of RNI in antimicrobial activity of macrophages, including the first evidence in vivo.
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(1990)
J Immunol
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Liew1
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46
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Microbiostatic Effect of Murine Macrophages for Toxoplasma gondii: Role of Synthesis of Inorganic Nitrogen Oxides from L-arginine
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of interest, Presents evidence for the involvement of RNI in antimicrobial activity of macrophages.
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(1990)
J Immunol
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Adams1
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The Involvement of Nitric Oxide in the Inhibition of the Phosphoroclastic System in Clostridium sporogenes By Sodium Nitrite
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Nitrite Inhibition of Clostridium botulinum. Electron Spin Resonance Detection of Iron-nitric Oxide Complexes
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Reddy1
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50
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0025045286
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Alterations of Ribonucleotide Reductase Activity Following Induction of the Nitrite-Generating Pathway in Adenocarcinoma Cells
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of interest, Identifies a specific target for RNIs that may account, in part, for their cytostatic effects.
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J Biol Chem
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Lepoivre1
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Mitochondrial Iron Loss From Leukemia Cells Injured by Macrophages. A Possible Mechanism For Electron Transport Chain Defects
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52
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0025117611
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EPR Demonstration of Iron-Nitrosyl Complex Formation by Cytotoxic Activated Macrophages
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of interest, Direct evidence that macrophage-derived RNIs interact with Fe-containing target molecules.
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Proc Natl Acad Sci USA
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Lancaster1
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53
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0025070321
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IFN-7-activated Macrophages: Detection by Electron Paramagnetic Resonance of Complexes Between L-arginine-derived Nitric Oxide and Non heme Iron Proteins
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of interest, Direct evidence that macrophage-derived RNIs interact with Fe-containing target molecules.
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Weinberg1
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84908765360
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Human Alveolar Macrophage Mediated Fungistasis Occurs Independently of L-arginine Oxidation
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of interest, RNI generation could not be implicated in the antifttngal action of human macrophages under conditions where murine macrophage-derived RNIs were effective.
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Cameron1
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Endothelial Cell Production of Nitrogen Oxides in Response to Interferon-y in Combination with Tumor Necrosis Factor, Interleukin-1 or Endotoxin
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