Human growth hormone replacement therapy: Pharmacological and clinical aspects

Endocrine Reviews

Volumn 12, Issue 3, 1991, Pages 189-207

  Otto, Jens ^a   JØRGENSEN, Lunde ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; SOMATOMEDIN B; SOMATOMEDIN C;

FEMALE; GROWTH HORMONE DEFICIENCY; GROWTH RETARDATION; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; REVIEW; SCHOOL CHILD; SUBCUTANEOUS DRUG ADMINISTRATION;

CHILD; COMPARATIVE STUDY; GROWTH HORMONE; HUMAN; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 0026014288     PISSN: 0163769X     EISSN: 0163769X     Source Type: Journal    
DOI: 10.1210/edrv-12-3-189     Document Type: Article

References (168)

1. Raben MS 1959 Human growth hormone. Recent Prog Horm Res 15:71
2. Beck JC, McGarry EE, Dyrenfurth I, Venning EH 1957 Metabolic effects of human and monkey growth hormone in man. Science 125:884
3. Raben MS 1958 Treatment of a pituitary dwarf with human growth hormone. J Clin Endocrinol Metab 18:901
4. Hutchings JJ, Escamilla RF, Deamer WC, Li CH 1959 Metabolic changes produced by human growth hormone (Li) in a pituitary dwarf. J Clin Endocrinol Metab 19:759
5. Ikkos D, Luft R, Gemzell C-A 1959 The effect of human growth hormone in man. Acta Endocrinol (Copenh) 32:341
6. Beck JC, McGarry EE, Dyrenfurth I, Morgen RO, Bird ED, Venning EH 1960 Primate growth hormone studies in man. Metabolism 9:699
7. Henneman PH, Forbes AP, Moldawer M, Dempsey EF, Carrol EL 1960 Effects of human growth hormone in man. J Clin Invest 39:1223
8. Raben MS 1962 Growth hormone (concluded) 2. Clinical use of human growth hormone. N Engl J Med 266:82
9. Soyka LF, Ziskind A, Crawford JD 1964 Treatment of short stature in children and adolescents with human pituitary growth hormone (Raben). Experience with thirty-five cases. N Engl J Med 271:754
10. Glick SM, Roth J, Yalow RS, Berson SA 1963 Immunoassay of human growth hormone in plasma. Nature 199:784
11. Goodman HG, Grumbach MM, Kaplan SL 1968 Growth and growth hormone. II. A comparison of isolated growth-hormone deficiency and multiple pituitary-hormone deficiencies in 35 patients with idiopathic hypopituitary dwarfism. N Engl J Med 278:57
12. Frasier SD 1983 Human pituitary growth hormone (hGH) therapy in growth hormone deficiency. Endocr Rev 4:155
13. Goeddel DV, Heyreker HL, Hozumi T, Arentzen R, Itakura K, Yansura DG, Ross MJ, Miozzari G, Crea R, Seeburg PH 1979 Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone. Nature 281:544
14. Hintz RL, Rosenfeld RG, Wilson DM, Bennett A, Finno J, McClellan B, Swift R 1982 Biosynthetic methionyl human growth hormone is biologically active in adult man. Lancet 1:1276
15. Raiti S 1985 Human growth hormone and Creutzfeld-Jakob disease. Ann Intern Med 103:288
16. Ban on growth hormone. Lancet 1:1972
17. Daughaday WH, Rotwein P 1989 Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev 10:68
18. Blum WF, Ranke MB, Jenne EW, Kietzman K, Bierich JR 1990 A specific radioimmunoassay for the growth hormone (GH) dependent somatomedin-binding protein: its use for diagnosis of GH deficiency. J Clin Endocrinol Metab 70:1292
19. Sandahl Christiansen J, Orskov H, Binder C, Kastrup KW 1983 Imitation of normal plasma growth hormone profile by subcutaneous administration of human growth hormone to growth hormone deficient children. Acta Endocrinol (Copenh) 102:6
20. Kastrup KW, Sandahl Christiansen J, Koch Andersen J, Orskov H 1983 Increased growth rate following transfer to daily sc administration from three weekly im injections of hGH in growth hormone deficient children. Acta Endocrinol (Copenh) 104:148
21. Hermanussen M, Geiger-Benoit K, Sippel WG 1985 Catch-up growth following transfer from three times weekly im to daily sc administration of hGH in GH deficient patients, monitored by knemometry. Acta Endocrinol (Copenh) 109:163
22. Albertsson-Wikland K, Westphal O, Westgren U 1986 Daily subcutaneous administration of human growth hormone in growth deficient children. Acta Psediatr Scand 75:89
23. Kikuchi K, Masakatsu S, Miyamoto A, Ohie T, Mori C, Mikawa H 1988 Growth response to daily subcutaneous administration of growth hormone. Acta Paediatr Jpn 30:557
24. Rimoin DL, Merimee TJ, Rabinowitz D, McKusick VA 1968 Genetic aspects of clinical endocrinology. Recent Prog Horm Res 24:365
25. Seip M, Van Der Hagen CB, Trygstad O 1968 Hereditary pituitary dwarfism with spontaneous puberty. Arch Dis Child 43:47
26. Laron Z, Sarel R, Pertzelan A 1980 Puberty in Laron type dwarfism. Eur J Pediatr 134:79
27. Burns EC, Tanner JM, Preece MA, Cameron N 1981 Growth hormone treatment in children with craniopharyngeoma: final growth status. Clin Endocrinol (Oxf) 14:587
28. Burns EC, Tanner JM, Preece MA, Cameron N 1982 Final height and pubertal development in 55 children with idiopathic growth hormone deficiency, treated for between 2 and 15 years with human growth hormone. Eur J Pediatr 137:155
29. Joss E, Zuppinger K, Schwarz HP, Roten H 1983 Final height of patients with pituitary growth failure and changes in growth variables after long term hormonal therapy. Pediatr Res 17:676
30. Bourguignon J-P, Vandweghe M, Vanderschueren-Loedeweyckx M, Malvaux P, Wolter R, Du Caju M, Ernould C 1989 Pubertal growth and final height in hypopituitary boys: a minor role of bone age at onset of puberty. J Clin Endocrinol Metab 63:376
31. Hibi I, Tanaka T 1989 Final height of patients with idiopathic growth hormone deficiency after long-term growth hormone treatment. Acta Endocrinol (Copenh) 120:409
32. Lenko HL, Leisti S, Perheentupa J 1982 The efficacy of growth hormone in different types of growth failure. An analysis of 101 cases. Eur J Pediatr 138:241
33. Dean HJ, McTaggart TT, Fish DG, Friesen HG 1985 The educational, vocational, and marital status of growth hormone-deficient adults treated with growth hormone during childhood. Am J Dis Child 139:1105
34. Tanner JM, Hughes PCR, Whitehouse RH 1977 Comparative rapidity of response of height, limb muscle and limb fat to treatment with human growth hormone in patients with and without growth hormone deficiency. Acta Endocrinol (Copenh) 84:681
35. Ranke M, Weber B, Bierich JR 1979 Long-term response to human growth hormone in 36 children with idiopathic growth hormone deficiency. Eur J Pediatr 132:221
36. Hennemann DH, Hennemann PH 1960 Effects of human growth hormone on levels of blood and urinary carbohydrate and fat metabolites in man. J Clin Invest 39:1239
37. Collip PJ, Curti V, Thomas J, Sharma RK, Maddaiah VT, Cohn SH 1973 Body composition changes in children receiving human growth hormone. Metabolism 22:589
38. Novak LP, Hayles AB, Cloutier MD 1972 Effect of hGH on body composition of hypopituitary dwarfs. Four-compartment analysis and composite body dentistry. Mayo Clin Proc 47:241
39. Parra A, Argote RM, Garcia GC, Cervantes C, Alatorre S, Perez-Pasten E 1979 Body composition in hypopituitary dwarfs before and during human growth hormone therapy. Metabolism 28:851
40. Rosenbaum M, Gertner JM, Leibel RL 1989 Effects of systemic growth hormone (GH) administration on regional adipose tissue distribution and metabolism in GH-deficient children. J Clin Endocrinol Metab 69:1274
41. Salmon WD, Daughaday WH 1957 A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med 49:825
42. Hall K, Olin P 1972 Sulphation factor activity and growth rate during long-term treatment of patients with pituitary dwarfism with human growth hormone. Acta Endocrinol (Copenh) 69:417
43. Rudman D, Moffitt SD, Fernhoff PM, McKenzie WJ, Kenny JM, Bain RP 1981 The relation between growth velocity and serum somatomedin C concentration. J Clin Endocrinol Metab 52:622
44. Schlach DS, Tollefsen SE, Klingensmith GJ, Gotlin RW, Diehl MJ 1982 Effects of human growth hormone administration on serum somatomedins, somatomedin carrier proteins, and growth rates in children with growth hormone deficiency. J Clin Endocrinol Metab 55:49
45. Albertsson-Wikland K, Hall K 1987 Growth hormone treatment in short children: relationship between growth and serum insulinlike growth factor I and II levels. J Clin Endocrinol Metab 65:671
46. Rosenfeld RG, Kemp SF, Hintz RL 1982 Constancy of somatomedin response to growth hormone treatment of hypopituitary dwarfs, and lack of correlation with growth rate. J Clin Endocrinol Metab 53:611
47. Dean HJ, Kellet RM, Bala HJ, Guyda HJ, Bhaumick B, Posner BI, Friesen HG. 1982 The effect of growth hormone treatment on somatomedin levels in growth hormone-deficient children. J Clin Endocrinol Metab 55:1167
48. Underwood LE, D’Ercole AJ, Clemmons DR, Van Wyk JJ 1986 Paracrine functions of somatomedins. Clin Endocrinol Metab 15:59
49. Jorgensen JOL, Flyvbjerg A, Lauritzen T, Alberti KGMM, Orskov Christiansen JS 1988 Dose-response studies with biosynthetic human growth hormone in growth hormone deficient patients. J Clin Endocrinol Metab 67:36
50. Zapf J, Walter H, Froesch ER 1981 Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia. J Clin Invest 68:1321
51. Hintz RL, Liu F 1982 A radioimmunoassay for insulin-like growth factor II specific for the C-peptide region. J Clin Endocrinol Metab 54:442
52. Engberg G, Hall K 1984 Immunoreactive IGF-II in serum of healthy subjects and patients with growth hormone disturbances and uremia. Acta Endocrinol (Copenh) 107:164
53. Blum WF, Ranke MB, Bierich JR 1988 A specific radioimmunoassay for insulin-like growth factor II: the interference of IGF binding proteins can be blocked by excess IGF-I. Acta Endocrinol (Copenh) 118:374
54. Grant MB, Schmetz I, Russel B, Harwood HJ, Silverstein J, Merimee T 1986 Changes in insulin-like growth factors I and II and their binding protein after a single intramuscular injection of growth hormone. J Clin Endocrinol Metab 63:981
55. Rosenfeld RG, Wilson DM, Lee PDK, Hintz RL 1986 Insulinlike growth factors I and II in evaluation of growth retardation. J Pediatr 109:428
56. Jdrgensen JOL, Blum WF, Mdller N, Ranke MB, Christiansen JS 1990 Circadian patterns of serum insulin-like growth factor (IGF) II and IGF binding protein 3 in growth hormone-deficient patients and age-and sex-matched normal subjects. Acta Endocrinol (Copenh) 123:257
57. Ranke MB, Blum WF, Bierich JR 1988 Clinical relevance of serum measurements of insulin-like growth factors and somatomedin binding proteins. Acta Paediatr Scand 347 [Suppl] 9:114
58. Reports of the nomenclature of the IGF binding proteins. J Clin Endocrinol Metab 1990;70:817-8
59. Copeland KC, Underwood LE, Van Wyk JJ 1980 Induction of immunoreactive somatomedin C in human serum by growth hormone: dose-response relationships and effect on chromatographic profiles. J Clin Endocrinol Metab 50:690
60. Baxter RC, Martin JL 1986 Radioimmunoassay of growth hormone dependent insulin-like growth factor binding protein in human plasma. J Clin Invest 78:1504
61. Tapanainen P, Risteli L, Knip M, Kaar M-L, Risteli J 1988 Serum aminoterminal propeptide of type III procollagen: a potential predictor of the response to growth hormone therapy. J Clin Endocrinol Metab 67:1244
62. Danne T, Gruters A, Schnabel K, Burger W, L’Allemand, Enders Helge H, Weber B, 1988 Long-term monitoring of treatment with recombinant human growth hormone by serial determinations of type III procollagen-related antigens in serum. Pediatr Res 23:167
63. Trivedi P, Hindmarsh P, Risteli J, Risteli L, Mowat AP, Brook CGD 1989 Growth velocity, growth hormone therapy, and serum concentrations of the amino-terminal propeptide of type III procollagen. J Pediatr 114:225
64. Carey DE, Goldberg B, Ratzan SK, Rubin KR, Rowe DR 1985 Radioimmunoassay for type I procollagen in growth hormone-deficient children before and during treatment with growth hormone. Pediatr Res 19:8
65. Delmas PD, Chatelain P, Malaval L, Bonne G 1986 Serum GLA-protein in growth hormone deficient children. J Bone Mineral Res 1:333
66. Wright JC, Brasel A, Aceto T, Finkelstein, Kenny FM, Spaulding JW, Blizzard RM 1965 Studies with human growth hormone (hGH). An attempt to correlate metabolic response during shortterm administration with linear growth during prolonged therapy. Am J Med 38:499
67. Costin G, Kogut MD, Frasier SD 1980 Effect of low-dose human growth hormone on carbohydrate metabolism in children with hypopituitarism. J Pediatr 80:796
68. Jorgensen JOL, Moller N, Lauritzen T, Alberti KGMM, Orskov H, Christiansen JS 1990 Evening versus morning injections of growth hormone (GH) in GH-deficient patients: effects on 24-hour patterns of circulating hormones and metabolites. J Clin Endocrinol Metab 70:207
69. Dahms WT, Owens RP, Kalhan SC, Kerr S, Danish RK 1989 Urea synthesis, nitrogen balance, and glucose turnover in growth-hormone-deficient children before and after growth hormone administration. Metabolism 38:197
70. Fryklund L 1987 Production of authentic recombinant somatropin. Acta Paediatr Scand [Supp l] 331:5
71. Dalbpge H, Dahl H-HM, Pedersen J, Hansen JW, Christensen T 1987 A novel enzymatic method for production of authentic hGH from an Escherichia coli produced hGH precursor. Biotechnology 5:161
72. Jorgensen JOL, Flyvbjerg A, Dinesen J, Lund H, Alberti KGMM, Orskov H, Christiansen JS 1987 Serum profiles and short-term metabolic effect of pituitary and authentic biosynthetic human growth hormone in a double-blind crossover study. Acta Endocrinol (Copenh) 116:381
73. Cameron DP, Burger HG, Catt KJ, Doig A 1969 Metabolic clearance rate of radioiodinated human growth hormone in man. J Clin Invest 48:1600
74. Taylor AL, Finster JL, Mintz DH 1969 Metabolic clearance and production rates of human growth hormone. J Clin Invest 48:2349
75. Macgillivray MH, Frohman LA, Doe J 1970 Metabolic clearance and production rates of human growth hormone in subjects with normal and abnormal growth. J Clin Endocrinol Metab 30:632
76. Kowarski A, Thompson RG, Migeon CJ, Blizzard RM 1971 Determination of integrated plasma concentrations and true secretion rates of human growth hormone. J Clin Endocrinol Metab 32:356
77. Owens D, Srivatava MC, Tompkins CV, Nabarro JDN, Sonksen PH 1973 Studies on the metabolic clearance rate, apparent distribution space and plasma half-disappearance time of unlabelled human growth hormone in normal subjects and in patients with liver disease, renal disease, thyroid disease and diabetes mellitus. Eur J Clin Invest 3:284
78. Baumann G 1979 Metabolic clearance rate of isohormones of human growth hormone in man. J Clin Endocrinol Metab 49:495
79. Jorgensen JOL, Flyvbjerg A, Christiansen JS 1989 The metabolic clearance rate, serum half-time and apparent distribution space of authentic biosynthetic human growth hormone in growth hormone-deficient patients. Acta Endocrinol (Copenh) 120:8
80. Faria ACS, Veldhuis JD, Thorner MO, Vance ML 1989 Half-time of endogenous growth hormone (GH) disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin. J Clin Endocrinol Metab 68:535
81. Rosenbaum M, Gertner JM 1989 Metabolic clearance rates of synthetic human growth hormone in children, adult women, and adult men. J Clin Endocrinol Metab 69:821
82. Hendricks CM, Eastman RC, Takeda S, Asakawa K, Gorden P 1985 Plasma clearance of intravenously administered pituitary human growth hormone: gel filtration studies of heterogenous components. J Clin Endocrinol Metab 60:864
83. Chawla RK, Parks JS, Rudman 1983 Structural variants of human growth hormone: biochemical, genetic, and clinical aspects. Annu Rev Med 34:519
84. Parker ML, Utger RD, Daughaday WH 1962 Studies on human growth hormone. II. The physiological disposition and metabolic fate of human growth hormone in man. J Clin Invest 41:262
85. Glick SM, Roth J, Lonergan ET 1964 Survival of endogenous human growth hormone in plasma. J Clin Endocrinol Metab 24:501
86. Refetoff S, Sönksen PH 1970 Disappearance rate of endogenous and exogenous human growth hormone in man. J Clin Endocrinol Metab 30:386
87. Hindmarsh PC, Matthews DR, Brain CE, Pringle PJ, Di Silvio L, Kurtz AB, Brook CGD 1989 The half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin. Clin Endocrinol (Oxf) 30:443
88. Documenta Geigy 1962 Composition of the body, body fluids and secretions. In: Diem K (ed) Documenta Geigy. J. R. Geigy S. A., Basle, Switzerland, p 516
89. Phillips JA, Hjelle BL, Seeburg PH, Zachmann M 1981 Molecular basis for familial isolated growth hormone deficiency. Proc Natl Acad Sei USA 78:6372
90. Illig R 1970 Growth hormone antibodies in patients with different preparations of human growth hormone. J Clin Endocrinol Metab 31:679
91. Kaplan SL, Underwood LE, August GP, Bell JJ, Blethen SL, Blizzard RM, Brown DR, Foley TP, Hintz RL, Hopwood NJ, Johansen A, Kirkland RT, Plotnick LP, Rosenfeld RG 1986 Clinical studies with recombinant-DNA-derived methionyl human growth hormone in growth hormone deficient children. Lancet 1:697
92. Milner RDG, Barnes ND, Buckler JMH, Carson DJ, Hadden DR, Hughes IA, Johnston DI, Parkin JM, Price DA, Rayner PHW, Savage DCL, Savage MO, Smith CS, Swift PGF 1987 United Kingdom multicentre trial of somatrem. Arch Dis Child 62:776
93. Gunnarson R, Wilton P 1987 Clinical experience with genotropin worldwide: an update March 1987. Acta Pædiatr Scand [Suppl] 337:147
94. Rasmussen LH, Zachmann M, Nilsson P 1988 Authentic recombinant human growth hormone. Results of a multicenter clinical trial in patients with growth hormone deficiency. Helv Paediatr Acta 43:443
95. Buzi F, Buchanan CR, Morrell DJ, Preece MA 1989 Antigenicity and efficacy of authentic sequence recombinant human growth hormone (somatropin): first-year experience in the United Kingdom. Clin Endocrinol (Oxf) 30:531
96. Tutweiler GF 1974 Further observation on a diabetogenic protein from bovine adenohypophysis. Int J Biochem 5:257
97. Bowden CR, White KD, Lewis UJ, Tutweiler GF 1985 Highly purified human growth hormone fails to stimulate lipolysis in rabbit adipocytes in vitro or in rabbits in vivo. Metabolism 4:237
98. Rosenfeld RG, Wilson DM, Dollar LA, Bennett A, Hintz RL 1982 Both human pituitary growth hormone and recombinant DNA-derived human growth hormone cause insulin resistance at a postreceptor site. J Clin Endocrinol Metab 54:1033
99. Van Vliet G, Bosson D, Craen M, Du Caju MVL, Malvaux P, Vandershueren-Loedeweyckx M 1987 Comparative study of the lipolytic potencies of pituitary-derived and biosynthetic human growth hormone in hypopituitary children. J Clin Endocrinol Metab 65:876
100. Underwood LE, Voina SJ, Van Wyk JJ 1974 Restoration of growth by human growth hormone (Roos) in hypopituitary dwarfs immunized by other human growth hormone preparations: clinical and immunological studies. J Clin Endocrinol Metab 38:288
101. Russo L, Moore W 1982 A comparison of subcutaneous and intramuscular administration of human growth hormone in the therapy of growth hormone deficiency. J Clin Endocrinol Metab 55:1003
102. Wilson DM, Baker B, Hintz RL, Rosenfeld RG 1985 Subcutaneous versus intramuscular growth hormone therapy: growth and acute somatomedin response. Pediatrics 76:361
103. Frasier SD, Costin G, Ling SM, Kaplan SA 1969 Plasma growth hormone concentration after a single intramuscular injection of human growth hormone. Pediatr Res 3:557
104. Wilton P, Sietnieks A 1987 An open-labelled study of the safety, acute metabolic activity and pharmacokinetic profile of a shortterm course of recombinant human growth hormone in healthy volunteers. Clin Endocrinol (Oxf) 26:125
105. Ho KY, Weissberger AJ, Stuart MC, Day RO, Lazarus L 1989 The pharmacokinetics, safety and endocrine effects of authentic biosynthetic human growth hormone in normal subjects. Clin Endocrinol (Oxf) 30;335
106. Binder C 1989 Absorption of injected insulin. Acta Pharmacol Toxicol (Copenh) 27[Suppl 2]:1
107. Cockshott WP, Thompson GT, Howlett LJ, Seeley ET 1982 Intramuscular or intralipomatous injections? N Engl J Med 307:356
108. Frid A, Lindén B 1986 Where do lean diabetics inject their insulin? A study using computed tomography. Br Med J 292:1638
109. Jprgensen JOL, Flyvbjerg A, Lauritzen T, Orskov H, Christiansen JS 1988 Subcutaneous degradation of biosynthetic human growth hormone in growth hormone deficient patients. Acta Endocrinol (Copenh) 118:154
110. Moore JA, Rudman CG, MacLachlan NJ, Fuller GB, Burnett B, Frane JW 1988 Equivalent potency and pharmacokinetics of recombinant human growth hormones with or without an N-terminal methionine. Endocrinology 122:2920
111. Chantelau E, Sonnenberg GE, Rajab A, Römisch J, Berger M 1985 Absorption of subcutaneously administered regular human and porcine insulin in different concentrations. Diabetes Metab 11:106
112. Lauritzen T, Thorsteinsson B, Pramming S, Sprensen L, Binder C 1984 Subcutaneous absorption of U-40 and U-100 insulin. Horm Metab Res 6:611
113. Jprgensen JOL, Mpller J, Lauritzen T, Christiansen JS 1989 The absorption kinetics of subcutaneously administered growth hormone: influence of injection volume. J Pediatr Endocrinol 3:213
114. Blizzard RM 1986 Psychosocial impact of long-term growth hormone therapy. In: Rait S, Tolman RA (eds) Human Growth Hormone. Plenum Medical Book Company, New York, p 93
115. Berger AS, Saurbrey N, Kühl C, Villumsen J 1985 Clinical experience with a new device that will simplify insulin injections. Diabetes Care 8:73
116. Jprgensen JOL, Flyvbjerg A, Jorgensen JT, Sdrensen HH, Johansen BR, Christiansen JS 1988 NPH insulin administration by means of a pen injector. Diabetic Med 5:574
117. Jprgensen JOL, Mpller J, Jensen FS, Jprgensen JT, Christiansen JS 1989 Growth hormone administration by means of an injection pen. Pharmacol Toxicol 65:96
118. Finkelstein JW, Roffwarg HP, Boyar RM, Kream J, Heilman 1972 Age-related changes in the twenty-four hour spontaneous secretion of growth hormone. J Clin Endocrinol Metab 35:665
119. Rudman D, Kutner H, Rogers CM, Lubin MF, Fleming GA, Bain RP 1981 Impaired growth hormone secretion in the adult population. Relation to age and adiposity. J Clin Invest 67:1361
120. Costin G, Kaufman FR, Brasel A 1989 Growth hormone secretory dynamics in subjects with normal stature. J Pediatr 115:537
121. Jansson J-O, Edén S, Isaksson O 1985 Sexual dimorphism in the control of growth hormone secretion. Endocr Rev 6:128
122. Roth J, Glick SM, Yalow RS, Berson SA 1963 Hypoglycemia: potent stimulus to secretion of growth hormone. Science 140:987
123. Ho KY, Veldhuis JD, Johnson ML, Furlanetto R, Evans WS, Alberti KGMM, Thorner MO 1988 Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest 81:968
124. Roth J, Glick SM, Yalow RS, Berson SA 1963 Secretion of human growth hormone: physiologic and experimental modification. Metabolism 12:577
125. Plotnick LP, Thompson RG, Kowacrski A, deLacerda L, Migeon CJ, Blizzard RM 1975 Circadian variation of integrated concentration of growth hormone in children and adults. J Clin Endocrinol Metab 40:240
126. Stolar MW, Baumann G 1986 Secretory patterns of growth hormone during basal periods in man. Metabolism 35:883
127. Soyka LF, Bode HH, Crawford JD, Flynn FJ 1970 Effectiveness of long-term human growth hormone therapy for short stature in children with growth hormone deficiency. J Clin Endocrinol Metab 30:1
128. Lippe BL, Frasier SD, Kaplan SA 1979 Use of growth hormonegel. Arch Dis Child 54:609
129. Rosenbloom AL 1966 Growth hormone replacement therapy. JAMA 198:130
130. Rosenbloom AL, Riley WJ, Silverstein JH, Garnica AD, Netzloff ML, Weber TH 1980 Low dose single weekly injections of growth hormone: response during first year of therapy of hypopituitarism. Pediatrics 66:272
131. Kirkland RT, Kirkland JL, Librik L, Clayton GW 1973 Results of intermittent human growth hormone (hGH) therapy in hypo-pituitary dwarfism. J Clin Endocrinol Metab 37:204
132. Frasier SD, Aceto T, Hayles AB 1978 Collaborative study of the effects of human growth hormone in growth hormone deficiency. V. Treatment with growth hormone administered once a week. J Clin Endocrinol Metab 47:686
133. Preece MA, Tanner JM 1977 Results of intermittent treatment of growth hormone deficiency with human growth hormone. J Clin Endocrinol Metab 45:169
134. Thorngren K-G, Hansson LI 1977 Effect of administration frequency of growth hormone on longitudinal bone growth in the hypophysectomized rat. Acta Endocrinol (Copenh) 84:497
135. Jansson J-O, Albertsson-Wikland K, Edén S, Thorngren K-G, Isaksson O 1982 Circumstantial evidence for a role of the secretory pattern of growth hormone in control of body growth. Acta Endocrinol (Copenh) 99:24
136. Jansson J-O, Albertsson-Wikland K, Edén S, Thorngren K-G, Isaksson O 1982 Effect of frequency of growth hormone administration on longitudinal bone growth and body weight in hypophysectomized rats. Acta Physiol Scand 114:261
137. Cotes PM, Bartlett WA, Gaines Das RE, Flecknell P, Termeer R 1980 Dose regimens of growth hormone: effects of continuous infusion and of a gelatine vehicle on growth in rats and rate of absorption in rabbits. J Endocr 87:303
138. Clark RG, Jansson J-O, Isaksson O, Robinson ICAF 1985 Intravenous growth hormone: growth responses to patterned infusions in hypophysectomized rats. J Endocrinol 104:53
139. Isgaard J, Carlsson L, Isaksson OGP, Jansson J-O 1988 Pulsatile intravenous growth hormone (GH) infusion to hypophysectomized rats increases insulin-like growth factor I messenger ribonucleic acid in skeletal tissues more effectively than continuous GH infusion. Endocrinology 123:2605
140. Davidson MB 1987 Effect of growth hormone on carbohydrate and lipid metabolism. Endocr Rev 8:115
141. Press M 1988 Growth hormone and metabolism. Diabetes Metab 4:391
142. Jprgensen JOL, Moller N, Lauritzen T, Christiansen JS 1990 Pulsatile versus continuous intravenous administration of growth hormone (GH) in GH deficient patients: effects on circulating insulin-like growth factor I and metabolic indices. J Clin Endocrinol Metab 70:1616
143. Hunter WM, Rigal WM 1966 The diurnal pattern of plasma growth hormone concentration in children and adolescents. J Endocrinol 34:147
144. Takahashi Y, Kipnis DM, Daughaday WH 1968 Growth hormone secretion during sleep. J Clin Invest 47:2079
145. Sassin JF, Parker DC, Mace JW, Gotlin RW, Johnson LC, Rossman LG 1969 Human growth hormone release: relation to slow-wave sleep and sleep-waking cycles. Science 105:513
146. Rudman D, Freides D, Patterson JH, Gibbas DL 1973 Diurnal variation in the responsiveness of human subjects to human growth hormone. J Clin Invest 52:912
147. Matustik MC, Furlanetto RW, Meyer WJ 1983 Chronobiologie considerations in human growth hormone therapy. J Pediatr 103:543
148. Féry F, Baiasse EO 1982 The alanine-ketone body cycle hypothesis. Metabolism 31:1179
149. Sherwin RS, Hendler RG, Felig P 1975 Effect of ketone infusion on amino acid and nitrogen metabolism in man. J Clin Invest 55:1382
150. Tait JF 1963 Review: the use of isotopic steroids for the measurement of production rates in vivo. J Clin Endocrinol Metab 23:1285
151. Albertsson-Wikland K, Rosberg S, Libre E, Lundberg L-O, Groth T 1989 Growth hormone secretory rates in children as estimated by deconvolution analysis of 24-h plasma concentration profiles. Am J Physiol 257:E809
152. Aceto T, Frasier SD, Hayles AB, Meyer-Bahlburg HFL, Parker ML, Munschauer R, Di Chiro G 1972 Collaborative study of the effects of human growth hormone in growth hormone deficiency. I. First year of therapy. J Clin Endocrinol Metab 35:483
153. Preece MA, Tanner JM, Whitehouse RH, Cameron N 1976 Dose dependence of growth response to human growth hormone in growth hormone deficiency. J Clin Endocrinol Metab 42:477
154. Frasier SD, Costin G, Lippe BM, Aceto T, Bunger PF 1981 A dose-response curve for human growth hormone. J Clin Endocrinol Metab 53:1213
155. Smith PJ, Hindmarsh PC, Brook CGD 1988 Contribution of dose and frequency of administration to the therapeutic effect of growth hormone. Arch Dis Child 63:491
156. Shizume K 1984 Long term effects of human growth hormone on 1, 959 patients with pituitary dwarfism throughout Japan. Endocrinol Jpn 31:210
157. Prinz PN, Weitzman ED, Cunningham GR, Karacan I 1983 Plasma growth hormone during sleep in young and aged men. J Gerontol 38:519
158. Rabinowitz D, Zierler K 1963 A metabolic regulating device based on the actions of human growth hormone and of insulin, singly and together, on the human forearm. Nature 199:913
159. Rudman D 1985 Growth hormone, body composition, and aging. J Am Geriatr Soc 33:800
160. Brasel JA, Wright JC, Wilkins L, Blizzard RM 1965 An evaluation of seventy-five patients with hypopituitarism beginning in childhood. Am J Med 38:484
161. Libber SM, Plotnick LP, Johanson AJ, Blizzard RM, Kwiterovich PO, Migeon CJ 1990 Long-term follow up of hypopituitary patients treated with human growth hormone. Medicine 69:46
162. Ranke MB 1987 A note on adults with growth hormone deficiency. Acta Pædiatr Scand [Suppl]331:80
163. Rosén T, Bengtsson B-Â 1990 Premature cardiovascular mortality in hypopituitarism—a study of 333 consecutive patients. Lancet 336:285
164. Almqvist O, Thorén M, Sääf M, Eriksson O 1986 Effects of growth hormone substitution on mental performance in adults with growth hormone deficiency: a pilot study. Psychoneuroendocrinology 11:347
165. Degerblad M, Grunditz R, Hall K, Sjöberg H-E, Sääf M, Thorén M 1987 Substitution therapy with recombinant growth hormone (somatrem) in adults with growth hormone deficiency. Acta Pædiatr Scand [Suppl] 331:170
166. Jorgensen JOL, Pedersen SA, Thuesen L, Jorgensen J, Ingemann-Hansen T, Skakkebæk NE, Christiansen JS 1989 Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1:1221
167. Whitehead HM, Atkinson AB, Kennedy AL, Hadden DR 1990 The growth hormone treatment of adults with growth hormone deficiency: beneficial effects related to an increased lean body mass. J Endocrinol Invest 13 [Suppl 2]:S98
168. Salomon F, Cuneo RC, Hesp R, Sönksen PH 1989 The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 321:1797