Pharmacokinetics and Immune Response of 131I-ChimericMouse/Human B72.3 (Human 74) Monoclonal Antibody in Humans

Cancer Research

Volumn 51, Issue 20, 1991, Pages 5461-5466

  Khazaeil, M B ^a,b,f   Colcher, David ^d   Seldom, Jeffrey ^d   Meredith, Ruby F ^a   Wheeler, Richard H ^a   Allen, Laquetta ^a   Rogers, Kim ^a   LoBuglio, Albert F ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

^c UCB PHARMA   (Belgium)

^d NATIONAL CANCER INSTITUTE   (United States)

^e PFIZER INC   (United States)

^f UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC ANTIBODY; IODINE 131; MONOCLONAL ANTIBODY B.72.3;

ANTIBODY LABELING; ARTICLE; CANCER IMMUNOTHERAPY; CLINICAL ARTICLE; COLORECTAL CANCER; HUMAN; IMMUNE RESPONSE; INTRAVENOUS DRUG ADMINISTRATION; PRIORITY JOURNAL;

ANIMAL; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, NEOPLASM; COLORECTAL NEOPLASMS; DRUG EVALUATION; GLYCOPROTEINS; HUMAN; MICE; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026005660     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Goldenberg, D. M., Goldenberg, H., Sharkey, R. M., Lee, R. E., Higgin-botham-Ford, E., Horowitz, J., Hall, T. G., Pinsky, C. M., and Hansen, H. J. Imaging of colorectal carcinoma with radiolabeled antibodies. Semin. Nud. Med., 4:262-281,1989.
2. Epenetos, A. A., Mather, S., Granowska, M., Niason, C. C., Hawkins, L. R., Britton, K. E., Shepherd, J., Taylor-Papadimitriou, J., Durbin, H., and Malpas, J. W. Targeting of iodine-125-labeled tumour associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumours. Lancet, 2: 999-1004,1982.
3. Order, S. E. Therapeutic use of radioimmunocoqjugates. Antibody Immunoconjugates Radiopharm., 2:235-239,1989.
4. Scheinberg, D., and Houghton, A. Current status of anti-tumor therapy with monoclonal antibodies. Oncology (Basel), 1:31-40, 1987.
5. Khazaeli, M., Saleh, M., Wheeler, R., Huster, W., Holden, H., Carrano, R., and LoBuglio, A. Phase I trial of multiple large doses of murine monoclonal antibody CO 17-1 A. II. Pharmacokinetics and immune response. J. Natl. Cancer Inst., 80:937-942,1988.
6. Pimm, M., Perkins, A., Armitage, N., and Baldwin, R. The characteristics of blood-borne radiolabels and the effect of anti-mouse IgG antibodies on localization of radiolabeled monoclonal antibody in caner patients. J. Nucl. Med., 26: 1011-1023, 1985.
7. LoBuglio, A., Saleh, M., Lee, J., Khazaeli, M., Carrano, R., Holden, H., and Wheeler, R. Phase I trial of multiple large doses of murine monoclonal antibody CO 17-1 A. I. Clinical aspects. J. Natl. Cancer Inst., 80: 932-936, 1988.
8. Meeker, T., Lowder, J., Maloney, D., Miller, R., Thielemans, K., Wainke, R., and Levy, R. A clinical trial of anti-idiotype therapy for B cell malignancy. Blood, 65:1349-1363,1985.
9. LoBuglio, A., Khazaeli, M., Lee, J., Haynes, A., Sumerel, L., Mischak, R., and Spitler, L. Pharmacokinetics and immune response to Xomazyme-mel in melanoma patients. Antibody Immunoconjugates Radiopharm., 1: 305-310,1988.
10. Morrison, S. Transfectomas provide novel chimeric antibodies. Science (Washington DC), 229:1202-1207,1985.
11. LoBuglio, A., Wheeler, R., Trang, J., Haynes, A., Rogers, K., Harvey, E., Sun, L., Ghrayeb, J., and Khazaeli, M. Mouse/human chimeric monoclonal antibody in man: kinetics and immune response. Proc. Natl. Acad. Sci. USA, 86:4220-4224,1989.
12. Johnson, V., Schlom, J., Patterson, A., Bennett, J., Magnani, J., and Colcher, D. Analysis of a human tumor associated glycoprotein (TAG-72) using monoclonal antibody B72.3. Cancer Res., 46:850-857,1986.
13. Thor, A., Ohuchi, N., Szpak, C., Johnston, W., and Schlom, J. The distribution of oncofetal antigen TAG-72 defined by monoclonal antibody B72.3. Cancer Res., 46:3118-3124,1986.
14. Whittle, N., Adair, J., Lloyd, C., Jenkins, L., Devin, J., Raubitschak, A., Colcher, D., and Bodner, M. Expression in COS cells of a mouse-human chimeric B72.3 antibody. Protein Eng., 1:499-505, 1987.
15. Colcher, D., Simpson-Milenic, D., Roselli, M., Yarrenton, G., King, D., Bodner, M., and Schlom, J. Characterization and biodistribution of recombinant and recombinant/chimeric constructs of monoclonal antibody B72.3. Cancer Res., 49:1738-1745,1989.
16. Lindmo, T., Boven, E., Cuttitta, F., Lindmo, T., Boren, E., Cuttitta, F., Fedorko, J., and Bun, P. A., Jr. Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess. J. Immunol. Methods, 72:77-89, 1984.
17. Meredith, R., LoBuglio, A., Plott, W., Orr, R., Brezovich, I., Russell, C., Harvey, E., Yester, M., Wagner, A., Spencer, S., Wheeler, R., Saleh, M., Rogers, K., Polansky, A., Salter, M., and Khazaeli, M. Pharmacokinetics, immune response, and biodistribution of 13lI-labeled chimeric mouse/human IgGl,* 17-1A monoclonal antibody. J. Nucl. Med., 32:1162-1168,1991.
18. Carrasquillo, J., Sugerbaker, P., Colcher, D., Reynolds, J., Esteban, J., Begent, G., Keenan, A., Perentesis, P., Yokoyama, K., Simpson, D., Ferroni, P., Farkas, R., Schlom, J., and Larsen, S. Radioimmunoscintigraphy of colon cancer with iodine 131-labeled B72.3 monoclonal antibody. J. Nucl. Med., 29:1022-1030, 1988.
19. Saleh, M., LoBuglio, A. F., Wheeler, R. H., Rogers, K. J., Haynes, A., Lee, J. Y., and Khazaeli, M. B. A Phase II trial of murine monoclonal antibody 17-1A and interferon-7: clinical and immunologic data. Cancer Immunol. Immunother., 32:185-190, 1990.
20. Court, W., and LoBuglio, A. Measurement of platelet surface bound IgG using a monoclonal radioimmune assay. Vox Sang., 50:154-159,1986.
21. Kubagawa, H., Mayumi, M., Kearney, J. F., and Cooper, M. D. Immunoglobulin VH determinants defined by monoclonal antibodies. J. Exp. Med., 156:1010-1024,1982.
22. Gero, E., Colcher, D., Ferroni, P., Molsheimer, R., Giani, S. Schlom, J., and Kaplan, P. CA72-4 radioimmunoassay for the detection of the TAG-72 carcinoma associated antigen in serum of patients. J. Gin. Lab. Anal., 3: 360-369,1989.
23. Kricks, L., Schmerfeld-Pruss, D., Senior, M., Goodman, D., and Kaladas, P. Interference by human anti-mouse antibody in two site immunoassays. Clin. Chem., 36:892-894, 1990.
24. Ferroni, P., Milenic, D., Schlom, J., and Colcher, D. Assay for detection of anti-idiotypic antibodies to monoclonal antibody B72.3. J. Clin. Lab. Anal., 4:465-473, 1990.
25. Liu, T. P. Characteristics of pharmacokinetic modeling in a Phase I clinical trial of radiolabeled monoclonal antibody chimeric B72.3 (Abstract). Controlled Clinical Trials, 12, in press, 1991.
26. Snederor, G. W., and Cochran, W. G. Correlation. In: Statistical Methods, pp. 175-188. Ames, IA: Iowa State University Press, 1980.
27. Maguire, R., Schmelter, R., Pascucci, V., and Conklin, J. Immunoscintigraphy of colorectal carcinoma: results with site specifically radiolabeled B72.3 (luIn-Cyt-103). Antibody Immunoconjugates Radiopharm., 2: 257-269, 1989.
28. Kaladas, P. M., Khazaeli, M., Hazzard, E., Vandervegt, D., LoBuglio, A., and Gilman, S. Detection of human anti-murine antibody (HAMA) following infusion of OncoScintR CR103. Comparison of ImmuSTRIP* ELISA with a double antigen radiometric assay. Antibody Immunoconjugates Radiopharm, 4:309-317, 1991.
29. Berzofsky, J. W. 1R genes: antigen specific genetic regulation of the immune response. In: M. Sela (ed.), The Antigens, Vol. 7, pp. 1-146. New York: Academic Press, 1987.
30. Baker, T., Begent, R., Divgi, M., and Secher, D. Characterization of the antibody response in patients undergoing radioimmunotherapy with chimeric B72.3. Antibody Immunoconjugates Radiopharm., 4:39A, 1991.
31. Morell, A., Terry, W., and Waldmann, T. Metabolic properties of IgG subclasses in man. J. Clin. Invest., 49:673-680, 1970.