Interleukin 10 (il-10) and viral il-10 strongly reduce antigen-specific human t cell proliferation by diminishing the antigen-presenting capacity of monocytes via dowm'egulation of class h major histocompatibility complex expression

Journal of Experimental Medicine

Volumn 174, Issue 4, 1991, Pages 915-924

  Waal Malefyt, René De ^a   Haanen, John ^a   Spits, Hergen ^a   Koncarolo, Maria Grazia ^a   Te Velde, Anje ^a,c   Figdor, Carl ^a,c   Johnson, Karen ^a,b   Kastelein, Rob ^a,b   Yssel, Hans ^a   De Vries, Jan E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Molecular Biology   (United States)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CELL GROWTH; CONTROLLED STUDY; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CALCIUM; CELL LINE, TRANSFORMED; CELLS, CULTURED; CLONING, MOLECULAR; CYTOKINES; DNA REPLICATION; FLUORESCENT ANTIBODY TECHNIQUE; GENES, MHC CLASS II; HERPESVIRUS 4, HUMAN; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMAN; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MONOCYTES; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES;

EID: 0026000892     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.174.4.915     Document Type: Article

References (38)

1. Fiorentino, D.F., M.W. Bond, and T.R. Mosmann. 1989. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Thl clones. J. Exp. Med. 170:2081.
2. Fiorentino, D.F., A. Zlotnik, P. Vieira, T.R. Mosmann, M. Howard, K.W. Moore, and A. O’Garra. 1991. IL-10 acts on the antigen presenting cell to inhibit cytokine production by Thl cells. J. Immunol. 146:3444.
3. Thompson-Snipes, L.A., V. Dhar, M.W. Bond, T.R. Mosmann, K.W. Moore, and D.M. Rsnnick. 1991. Interleukin 10: a novel stimulatory factor for mast cells and their progenitors. J. Exp. Med. 173:507.
4. MacNeil, I.A., T. Suda, K.W. Moore, T.R. Mosmann, and A. Zlotnik. 1990. IL-10, a novel growth cofactor for mature and immature T cells. J. Immunol. 145:4167.
5. Go, N.F., B.E. Castle, R. Barrett, R. Kastelein, W. Dang, T.R. Mosmann, K.W. Moore, and M. Howard. 1990. Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome linked immunodeficiency B cells. J. Exp. Med. 172:1625.
6. O’Garra, A., G. Stapleton, V. Dhar, M. Pearce, J. Schumacher, H. Rugo, D. Barbis, A. Stall, J. Cupp, K. Moore, P. Vieira, T. Mosmann, A. Whitmore, L. Arnold, G. Haughton, and M. Howard. 1990. Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10. Int. Immunol. 2:821.
7. Vieira, P., R. de Waal Malefyt, M.-N. Dang, K.E. Johnson, R. Kastelein, D.F. Fiorentino, J.E. de Vries, M.-G. Roncarolo, T.R. Mosmann, and K.W. Moore. 1991. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRF1. Proc. Natl. Acad. Sci. USA. 88:1172.
8. Moore, K.W., P. Vieira, D.F. Fiorentino, M.L. Trounstine, T.A. Khan, and T.R. Mosmann. 1990. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRF1. Science (Wash. DC). 248:1230.
9. Hsu, D.-H., R. de Waal Malefyt, D.F. Fiorentino, M.-N. Dang, P. Vieira, J.E. de Vries, H. Spits, T.R. Mosmann, and K.W. Moore. 1990. Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1. Science (Wash. DC). 250:830.
10. + T cell subset with an unrestricted cytokine profile. J. Immunol 143:518.
11. + T cell clones./. Immunol. 141:849.
12. + T cells./. Immunol. 146:1341.
13. Haanen, J.B.A.G., R. de Waal Malefyt, P.C.M. Res, E.M. Kraakman, T.H.M. Ottenhof, R.R.P. de Vries, and H. Spits. 1991. Selection of a human Thl like T cell subset by mycobacteria. J. Exp. Med. 174:583.
14. Yssel, H., D. Blanchard, A. Boylston, J.E. de Vries, and H. Spits. 1986. T cell clones which share T cell receptor epitopes differ in phenotype, function and specificity. Eur. J. Immunol. 16:1187.
15. Ottenhoff, T.H.M., and T. Mutis. 1990. Specific killing of cytotoxic T cells and antigen presenting cells by CD4' cytotoxic T cell clones: a novel potentially immunoregulatory TT cell interaction in man. J. Exp. Med. 171:2011.
16. Smith, D.B., and K.S. Johnson. 1988. Single step purification of polypeptides expressed in E. coli as fusions with glutathione-S-transferase. Gene (Amst.). 67:31.
17. Anderson, D.C., M.E. Barry, and T.M. Buchanan. 1988. Exact definition of species specific and crossreactive epitopes of the 65 kilodalton protein of Mycobacterium leprae using synthetic peptides. J. Immunol. 137:952.
18. Figdor, C.G., W.S. Bont, I. Touw, D. Roos, E.E. Roosnek, and J.E. de Vries. 1982. Isolation of functionally different human monocytes by counterflow centrifugation elutriation. Blood. 60:46.
19. Figdor, C.G., W.L. van Es, J.M.M. Leemans, and W.S. Bont. 1984. A centrifugal elutriation system of separating small numbers of cells. J. Immunol. Methods. 68:73.
20. Koning, F., G.M.T.H. Schrender, M. Giphart, and J.W. Bruning. 1984. A mouse monoclonal antibody detecting a DR-related MT2-like specificity: serology and biochemistry. Hum. Immunol 9:221.
21. Quaranta, V., L.E. Walker, M.A. Felligrino, and S. Ferrone. 1990. Purification of immunobiologically functional subsets of human Ia-like antigens on a monoclonal antibody (Q5/13) immunoadsorbent. J. Immunol 136:2348.
22. Buus, S., A. Sette, S.M. Colon, D.M. Jenis, and H.M. Grey. 1986. Isolation and characterization of antigen Ia complexes involved in T cell recognition. Cell 47:1071.
23. Smith, B.R., and K.A. Ault. 1981. Increase of surface Ia-like antigen expression on human monocytes independent of antigenic stimuli. J. Immunol. 127:2020.
24. Braciale, T.J., L.A. Morrison, M.T. Sweetser, J. Sambrook, M.-J. Gething, and V.L. Braciale. 1987. Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes. Immunol. Rev. 98:95.
25. Buus, S., A. Sette, and H.M. Grey. 1987. The interaction between protein-derived immunogenic peptides and Ia. Immunol. Rev. 98:115.
26. Shimizu, Y., G.A. van Seventer, K.J. Horgan, and S. Shaw. 1990. Roles of adhesion molecules in T cell recognition: fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding and costimulation. Immunol. Rev. 114:109.
27. Larson, R.S., and T.A. Springer. 1990. Structure and function of leukocyte integrins. Immunol Rev. 114:181.
28. Harding, C.V., and E.R. Unanue. 1990. Quantitation of antigen presenting cell MHC class II/peptide complexes necessary for T cell stimulation. Nature (Lond.). 346:574.
29. Neees, J.F., V. Stollorz, P.F. Peters, H.J. Geuze, and H.L. Ploegh. 1990. The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytotic route. Cell. 61:171.
30. Harding, C.V., E.R. Unanue, J.W. Slot, A.L. Swartz, and H.F. Geuze. 1990. Functional and ultrastructural evidence for intracellular formation of major histocompatibility complex class II peptide complexes during antigen processing. Proc. Natl. Acad Sci. USA. 87:5553.
31. Davis, J.E., and P. Cresswell. 1990. Lack of detectable endocy-tosis of B lymphocyte MHC class II antigens using an antibody independent technique. J. Immunol 144:990.
32. de Waal Malefyt, R., J. Abrams, E Bennett, C. Fidgor, and J.E. de Vries. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp Med. In press.
33. Duran, S.K., J.A. Smith, and J. Oppenheim. 1985. IL-1: an immunological perspective. Annu. Rev. Immunol 3:263.
34. Kishimoto, T. 1989. The biology of interleukin-6. Blood. 74:1.
35. Tosato, G., and S.E. Pike. 1988. Interferon-/3/interleukin 6 is a costimulant for human T lymphocytes. J. Immunol 141:1556.
36. Scheurich, P., B. Thomas, U. Ucer, and K. Pfizenmaier. 1987. Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-a: induction of TNF receptors on human T cells and TNF-a-mediated enhancement of T cell responses. J. Immunol. 138:1786.
37. Assoian, R.K., B.E. Fleurdelys, H.C. Stevenson, P.J. Miller, D.K. Madtes, E.W. Raines, R. Ross, and M.B. Spom. 1987. Expression and secretion of type /3 transforming growth factor by activated human macrophages. Proc Natl Acad. Sci. USA. 84:6020.
38. te Velde, A.A., R.J.F. Huijbens, K. Heije, J.E. de Vries, and C.G. Figdor. 1990. Interleukin 4 (IL-4) inhibits secretion of IL-1/3, tumor necrosis factor-a, and IL-6 by human monocytes. Blood. 76:1392.