Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication

Proceedings of the National Academy of Sciences of the United States of America

Volumn 88, Issue 19, 1991, Pages 8806-8810

  Romero, D L ^a   Busso, M ^b   Tan, C K ^c   Reusser, F ^a   Palmer, J R ^a   Poppe, S M ^a   Aristoff, P A ^a   Downey, K M ^c   So, A G ^c   Resnick, L ^b   Tarpley, W G ^a  

^a PFIZER INC   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

^c UNIVERSITY OF MIAMI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FELIDAE; FELINE IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; MURINAE; MURINE LEUKEMIA VIRUS; RAUSCHER MURINE LEUKEMIA VIRUS; SIMIAE; ANIMALIA;

2',3' DIDEOXYADENOSINE; 2',3' DIDEOXYTHYMIDINE; PIPERAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION;

ANIMAL; ANTIVIRAL AGENTS; CELL SURVIVAL; DNA, VIRAL; DRUG SYNERGISM; HIV-1; MICE; MICE, NUDE; PIPERAZINES; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE INHIBITORS; RNA, VIRAL; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THYMINE NUCLEOTIDES; VIRUS REPLICATION; ZIDOVUDINE;

EID: 0025996983     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.88.19.8806     Document Type: Article

References (28)

1. Ratner, L., Haseltine, W., Patarca, R., Livak, K. J., Starcich, B., Josephs, S. F., Doran, E. R., Rafalski, J. A., Whitehorn, E. A., Baumeister, K., Ivanoff, L., Petteway, S. R., Jr., Pearson, M. L., Lautenberger, J. A., Papas, T. S., Ghrayeb, J., Chang, N. T., Gallo, R. C. & Wong-Staal, F. (1985) Nature (London) 313, 277-284.
2. Barre-Sinoussi, F., Chermann, J. C., Rey, F., Nugeyre, M. T., Chamaret, S., Gruest, J., Dauguet, C., Axler-Blin, C., Vezinet-Brun, F., Rouzioux, C., Rozenbaum, W. & Montagnier, L. (1983) Science 220, 868-870.
3. Varmus, H. (1988) Science 240, 1427-1434.
4. Mitsuya, H. & Broder, S. (1987) Nature (London) 325, 773-778.
5. Fischl, M. A., Richman, D. D., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., Leedom, J. M., Groopman, J. E., Mildvan, D., Schooley, R. T., Jackson, G. G., Durack, D. T., King, D. & The AZT Collaborative Working Group (1987) N. Engl. J. Med. 317, 185-191.
6. Yarchoan, R., Mitsuya, H., Thomas, R. V., Pluda, J. M., Hartman, N. R., Perno, C.-F., Marczyk, K. S., Allain, J.-P Johns, D. G. & Broder, S. (1989) Science 245, 412-417.
7. Yarchoan, R., Mitsuya, H., Myers, C. E. & Broder, S. (1989) N. Engl. J. Med. 321, 726-738.
8. Richman, D. D., Fischl, M. A., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., Leedom, J. M., Groopman, J. E., Mildvan, D., Hirsch, M. S., Jackson, G. G., Durack, D. T., Phil, D., Nusinoff-Lehrman, S. & The AZT Collaborative Working Group (1987) N. Engl. J. Med. 317, 192-197.
9. Larder, B. A., Darby, G. & Richman, D. D. (1989) Science 243, 1731-1734.
10. Larder, B. A. & Kemp, S. D. (1989) Science 246, 1155-1158.
11. Pauwels, R., Andries, K., Desmyter, J., Schols, D., Kukla, M. J., Breslin, H. J., Raeymaeckers, A., Van Gelder, J., Woestenborghs, R., Heykants, J., Schellekens, K., Janssen, M. A. C., De Clercq, E. & Janssen, P. A. J. (1990) Nature (London) 343, 470-474.
12. Merluzzi, V. J., Hargrave, K. D., Labadia, M., Grozinger, K., Skoog, M., Wu, J. C., Shih, C.-K., Eckner, K., Hattox, S., Adams, J., Rosenthal, A. S., Faanes, R., Eckner, R. J., Koup, R. A. & Sullivan, J. L. (1990) Science 250, 1411-1413.
13. Busso, M., Mian, A. M., Hahn, E. F. & Resnick, L. (1988) AIDS Res. Hum. Retroviruses 4, 449-455.
14. Resnick, L., Markham, P. D., Veren, K., Salahuddin, S. Z. & Gallo, R. C. (1986) J. Infect. Dis. 154, 1027-1030.
15. McQuade, T. J., Tomasselli, A. G., Liu, L., Karacostas, V., Moss, B., Sawyer, T. K., Heinrikson, R. L. & Tarpley, W. G. (1990) Science 247, 454-456.
16. Rubsamen-Waigmann, H., Becker, W. B., Helm, E. B., Brodt, R., Fischer, H., Henco, K. & Brede, H. D. (1986) J. Med. Virol. 19, 335-344.
17. Deibel, M. R., McQuade, T. J., Brunner, D. P. & Tarpley, W. G. (1990) AIDS Res. Hum. Retroviruses 6, 329-340.
18. Tan, C.-K., Zhang, J., Li, Z.-Y., Tarpley, W. G., Downey, K. M. & So, A. G. (1991) Biochemistry 30, 2651-2655.
19. Tan, C.-K., Castillo, C., So, A. G. & Downey, K. M. (1986) J. Biol. Chem. 261, 12310-12316.
20. Chou, T.-C. & Talalay, P. J. (1984) Adv. Enzyme Regul. 22, 27-55.
21. McCune, J. M., Namikawa, R., Shih, C.-C., Rabin, L. & Kaneshima, H. (1990) Science 247, 564-566.
22. Lajiness, M. S., Johnson, M. A. & Maggiora, G. M. (1989) in Quantitative Structure-Activity Relationships in Drug Design, ed. Fauchere, J. L. (Liss, New York), Vol. 291, pp. 173-176.
23. Byrnes, J. J., Downey, K. M., Black, V. L. & So, A. G. (1976) Biochemistry 15, 2817-2823.
24. Koyanagi, Y., Miles, S., Mitsuyasu, R. T., Merrill, J. E., Vinters, H. V. & Chen, I. S. Y. (1987) Science 236, 819-822.
25. Williams, D. A. (1981) in Principles of Medicinal Chemistry, ed. Foye, W. O. (Lea & Febiger, Philadelphia), pp. 91-128.
26. Sundberg, R. J. (1970) in The Chemistry of Indoles, ed. Blomquist, A. (Academic, New York), pp. 308-310.
27. Le Grice, S. F. J., Zehnle, R. & Mous, J. (1988) J. Virol. 62, 2525-2529.
28. Guyader, M., Emerman, M., Sonigo, P., Clavel, F., Montagnier, L. & Alizon, M. (1987) Nature (London) 326, 662-669.