Licorice-induced hypermineralocorticoidism

New England Journal of Medicine

Volumn 325, Issue 17, 1991, Pages 1223-1227

  Farese, Robert V ^a   Biglieri, Edward G ^a   Shackleton, Cedric H l ^a   Irony, Ilan ^a   Gomez Fontes, Rosita ^b  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; GLYCYRRHIZIC ACID; MINERALOCORTICOID; POTASSIUM CHLORIDE; SPIRONOLACTONE; VERAPAMIL;

ADVERSE DRUG REACTION; AGED; ARTICLE; CASE REPORT; DRUG ABUSE; DRUG BLOOD LEVEL; DRUG INTOXICATION; ENZYME ACTIVITY; GLYCYRRHIZA; HUMAN; HYPOKALEMIA; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SIDE EFFECT; SODIUM RETENTION; WATER RETENTION;

AGED; ALDOSTERONE; CASE REPORT; DESOXYCORTICOSTERONE; FOOD POISONING; GLYCYRRHETINIC ACID; GLYCYRRHIZA; HUMAN; HYDROCORTISONE; HYDROXYSTEROID DEHYDROGENASES; HYPERTENSION; HYPOKALEMIA; MALE; MINERALOCORTICOIDS; PLANTS, MEDICINAL; RENIN; SUPPORT, U.S. GOV'T, P.H.S.; WATER-ELECTROLYTE IMBALANCE;

EID: 0025989937     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199110243251706     Document Type: Article

References (17)

1. Card WI, Mitchell W, Strong JA, Taylor NRW, Tompsett SL, Wilson JMG. Effects of liquorice and its derivatives on salt and water metabolism. Lancet 1953; 1: 663–8.
2. Borst JGG, ten Holt SP, deVries LA, Molhuysen JA. Synergistic action of liquorice and cortisone in Addison's and Simmonds's disease. Lancet 1953; 1: 657–63.
3. Armanini D, Karbowiak I, Funder JW. Affinity of liquorice derivatives for mineralocorticoid and glucocorticoid receptors. Clin Endocrinol (Oxf) 1983; 19: 609–12.
4. Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CHL, Edwards CRW. Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase activity comes of age. Lancet 1987; 2: 821–4.
5. Shackleton CHL, Stewart PM. The hypertension of apparent mineralocorticoid excess (AME) syndrome. In: Biglieri EG, Melby JC, eds. Endocrine hypertension. New York: Raven Press, 1990:155–73.
6. Arriza JL, Weinberger C, Cerelli G, et al. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 1987; 237: 268–75.
7. Edwards CRW, Stewart PM, Burt D, et al. Localisation of 11β-hydroxysteroid dehydrogenase — tissue specific protector of the mineralocorticoid receptor. Lancet 1988; 2: 986–9.
8. Funder JW, Pearce PT, Smith R, Smith AI. Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science 1988; 242: 583–5.
9. Epstein MT, Espiner EA, Donald RA, Hughes H. Liquorice toxicity and the renin–angiotensin–aldosterone axis in man. BMJ 1977; 1: 209–10.
10. Kater CE, Biglieri EG, Brust N, Chang B, Hirai J, Irony I. Stimulation and suppression of mineralocorticoid hormones in normal subjects and adrenocorticoid disorders. Endocr Rev 1989; 10: 149–64.
11. Stockigt JR, Collins RD, Biglieri EG. Determination of plasma renin concentrations by angiotensin I immunoassay: diagnostic importance of precise measurements of subnormal renin in hypoaldosteronism. Circ Res 1971; 28: Suppl 2: 175–91.
12. Shackleton CHL, Merderk J, Lawson AM. Steroid and bile acid synthesis. In: McEwen CN, Larson BS, eds. Mass spectrometry of biological materials. New York: Marcel Dekker, 1990:297–377.
13. Fales HN, Jaouni TJ, Babashak JF. Simple device for preparing ethereal diazomethane without resorting to codistillation. Anal Chem 1973; 45: 2302–3.
14. Epstein MT, Espiner EA, Donald RA, Hughes H, Cowles RJ, Lun S. Licorice raises urinary cortisol in man. J Clin Endocrinol Metab 1978; 47: 397–400.
15. Monder C, Shackleton CHL. 11β-hydroxysteroid dehydrogenase: fact or fancy? Steroids 1984; 44: 383–417.
16. Monder C, Shackleton CHL, Bradlow HL, et al. The syndrome of apparent mineralocorticoid excess: its association with 11β-dehydrogenase and 5β-reductase deficiency and some consequences for corticosterone metabolism. J Clin Endocrinol Metab 1986; 65: 550–7.
17. Biglieri EG, Slaton PE Jr, Silen WS, Galante M, Forsham PH. Postoperative studies of adrenal function in primary aldosteronism. J Clin Endocrinol Metab 1966; 26: 553–8.