Discordance of T‐cell receptor β‐chain genes in familial multiple sclerosis

Annals of Neurology

Volumn 30, Issue 3, 1991, Pages 402-410

  Lynch, Sharon G ^a,c   Rose, John W ^a,c   Petajan, Jack H ^c   Stauffer, Dora ^b   Kamerath, Craig ^a   Leppert, Mark ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENETICS; HUMAN; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; T LYMPHOCYTE;

ALLELES; DNA; FAMILY; FEMALE; HUMAN; LINKAGE (GENETICS); MAGNETIC RESONANCE IMAGING; MALE; MULTIPLE SCLEROSIS; NUCLEIC ACID HYBRIDIZATION; ODDS RATIO; PEDIGREE; POLYMORPHISM (GENETICS); POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.;

EID: 0025986996     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.410300313     Document Type: Article

References (45)

1. Multiple sclerosis
2. Genetic susceptibility to multiple sclerosis
3. Genetic susceptibility to multiple sclerosis. A linkage analysis with age of onset corrections
4. The familial nature of multiple sclerosis: age‐corrected empiric recurrence risks for children and siblings of patients
5. The genetics of susceptibility to multiple sclerosis
6. Updated risks for relatives
7. A population‐based study of multiple sclerosis in twins
8. Multiple sclerosis in twins
9. Studies of multiple sclerosis in twins, using nuclear magnetic resonance
10. HLA and multiple sclerosis; population and families study
11. Multiple sclerosis in Northeast Scotland: an association with HLA‐DQwl
12. HLA and multiple sclerosis in Southeast Wales
13. Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis
14. Multiple sclerosis: distribution of T cell subsets within active chronic lesions
15. Immunoregulatory molecules and IL‐2 receptors identified in multiple sclerosis brain
16. Neurological autoimmune disease and the trimolecular complex of T‐lymphocytes
17. Murine T cell receptor mutants with deletions of beta chain variable region genes
18. Adoptive transfer of MBP‐sensitized T‐cell produces chronic relapsing demyelinating disease in mice
19. B gene subfamily in autoimmune encephalomyelitis
20. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention
21. Shared human T cell receptor usage to immunodominant regions of myelin basic protein
22. Limited heterogeneity of rearranged T‐cell receptor V alpha transcripts in brains of multiple sclerosis patients
23. The germline repertoire of T cell receptor beta chain genes in patients with chronic progressive multiple sclerosis
24. A susceptibility locus for multiple sclerosis is linked to the T cell receptor beta chain complex
25. New diagnostic criteria for multiple sclerosis: guidelines for research protocols
26. MRI in familial multiple sclerosis
27. A routine method for the establishment of permanent growing lymphoblastoid cell lines
28. Polymorphic DNA region adjacent to the 5′ end of the human insulin gene
29. Rapid transfer of DNA from agarose gels to nylon membranes
30. Rearrangement of the beta chain of the T cell antigen receptor and the immunoglobulin genes in lymphoproliferative disorders
31. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity
32. The use of NaOH as transfer solution of DNA onto nylon membranes decreases the hybridization efficiency
33. Multilocus linkage analysis in humans: detection of linkage and estimate of recombination
34. Higher than expected prevalence of multiple sclerosis in northern Colorado: dependence on methodologic issues
35. Segregation of ploymorphic T‐cell receptor genes in human families
36. Detection and mapping of polymorphic KpnI alleles in the human T‐cell receptor constant beta‐2 locus
37. Human T cell receptor mutants with deletions of chain variable region genes
38. Genes encoding the alpha, beta, and gamma chains of the human T cell receptor
39. A speculative view of the multicomponent nature of T cell antigen recognition
40. Systemic lupus erythematosus is not genetically linked to the beta chain of the T cell receptor
41. Nonlinkage of the T cell receptor alpha, beta, and gamma genes to systemic lupus erythematosus in multiplex families
42. HLA‐DQ and T cell receptor genes in insulin dependent diabetes mellitis
43. Association of HLA antigen and restriction fragment length polymorphisms of the T cell receptor beta chain gene with Graves' disease and Hashimoto's thyroiditis
44. T‐cell receptor genes and insulin‐dependent diabetes mellitus (IDDM): no evidence for linkage from affected sib pairs