Translocations, master genes, and differences between the origins of acute and chronic leukemias

Cell

Volumn 67, Issue 4, 1991, Pages 641-644

  Rabbitts, Terence H ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LEUKEMIA; CHROMOSOME TRANSLOCATION; CHRONIC LEUKEMIA; GENETIC DISORDER; HUMAN; MUTATION; PRIORITY JOURNAL; SHORT SURVEY;

ACUTE DISEASE; CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; CHRONIC DISEASE; HUMAN; LEUKEMIA; LYMPHOMA; MUTATION; PROTO-ONCOGENES; TIME FACTORS; TRANSLOCATION (GENETICS);

EID: 0025984266     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(91)90057-6     Document Type: Short Survey

References (30)

1. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
2. Bcl-2/JH rearrangements in benign lymphoid tissues with follicular hyperplasia.
3. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11).
4. TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia.