Potential-dependent inhibition of cardiac Ca2+ inward currents by Ro 40-5967 and verapamil: relation to negative inotropy

European Journal of Pharmacology

Volumn 196, Issue 2, 1991, Pages 205-207

  Liang min, Fang ^a   Osterrieder, Wolfgang ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Ca2+ channel antagonists; Potential dependent block; Ro 40 5967; Verapamil

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; MIBEFRADIL; TETRODOTOXIN; VERAPAMIL;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; GUINEA PIG; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL;

ANIMAL; BENZIMIDAZOLES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; COMPARATIVE STUDY; DEPRESSION, CHEMICAL; GUINEA PIGS; IN VITRO; MEMBRANE POTENTIALS; MIBEFRADIL; MYOCARDIAL CONTRACTION; TETRAHYDRONAPHTHALENES; VERAPAMIL;

EID: 0025982071     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(91)90430-X     Document Type: Article

References (9)

1. The voltage- and time-dependent effects of ( − )-verapamil on the slow inward current in isolated cat ventricular myocardium
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5. Studies on the inhibitory effect on the slow inward current in mammalian ventricular myocardium
6. On the mechanism of slow calcium channel Mock in heart
7. 2+ channel blocker with potent vasodilator but weak inotropic action
8. Calcium channel block and recovery from block in mammalian ventricular muscle treated with organic channel inhibitors