Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 88, Issue 4, 1991, Pages 1330-1334

  Palmer, Theo D ^a   Rosman, Guy J ^a   Osborne, William R A ^b   Dusty Miller, A ^a  

^a FRED HUTCHINSON CANCER RESEARCH CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Adenosine deaminase; Gene therapy; Neomycin phosphotransferase; Retroviral vectors; Severe combined immunodeficiency

Indexed keywords

ANIMALIA; UNIDENTIFIED RETROVIRUS;

VIRUS VECTOR;

ANIMAL CELL; ARTICLE; CELL TRANSPLANTATION; COMBINED IMMUNODEFICIENCY; GENE THERAPY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RETROVIRUS; SKIN FIBROBLAST;

ADENOSINE DEAMINASE; ANIMAL; BASE SEQUENCE; CELL SURVIVAL; CELLS, CULTURED; DNA; FIBROBLASTS; GENE THERAPY; GENETIC ENGINEERING; GENETIC VECTORS; GRAFT SURVIVAL; HUMAN; MALE; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE PROBES; PLASMIDS; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED F344; REPETITIVE SEQUENCES, NUCLEIC ACID; SIMIAN VIRUS 40; SKIN; SKIN TRANSPLANTATION; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0025976935     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.88.4.1330     Document Type: Article

References (28)

1. Miller, A. D. (1990) Blood 76, 271-278.
2. Garver, R. I., Jr., Chytil, A., Courtney, M. & Crystal, R. G. (1987) Science 237, 762-764.
3. Selden, R. F., Skoskiewicz, M. J., Russell, P. S. & Goodman, H. M. (1987) N. Engl. J. Med. 317, 1067-1076.
4. Rosenberg, M. B., Friedmann, T., Robertson, R. C., Tuszynski, M., Wolff, J. A., Breakefield, X. O. & Gage, F. H. (1988) Science 242, 1575-1578.
5. St. Louis, D. & Verma, I. M. (1988) Proc. Natl. Acad. Sci. USA 85, 3150-3154.
6. Palmer, T. D., Thompson, A. R. & Miller, A. D. (1989) Blood 73, 438-445.
7. Wolff, J. A., Fischer, L. J., Xu, L., Jinnah, H. A., Langlais, P. J., Iuvone, P. M., O'Malley, K. L., Rosenberg, M. B. Shimohama, S. & Friedmann, T. (1989) Proc. Natl. Acad. Sci. USA 86, 9011-9014.
8. Ham, R. G. (1980) Methods Cell Biol. 21a, 255-276.
9. Hock, R. A., Miller, A. D. & Osborne, W. R. A. (1989) Blood 74, 876-881.
10. Miller, A. D. & Buttimore, C. (1986) Mol. Cell. Biol. 6, 2895-2902.
11. Miller, A. D., Trauber, D. R. & Buttimore, C. (1986) Somatic Cell Mol. Genet. 12, 175-183.
12. Osborne, W. R. A. & Miller, A. D. (1988) Proc. Natl. Acad. Sci. USA 85, 6851-6855.
13. Palmer, T. D., Hock, R. A., Osborne, W. R. A. & Miller, A. D. (1987) Proc. Natl. Acad. Sci. USA 84, 1055-1059.
14. Yannas, I. V., Burke, J. F., Orgill, D.-P. & Skrabut, E. M. (1982) Science 215, 174-176.
15. Osborne, W. R. A. (1980) J. Biol. Chem. 255, 7089-7092.
16. Osborne, W. R. A. & Spencer, N. (1973) Biochem. J. 133, 117-123.
17. Zieverink, W. D. & Moloney, W. C. (1965) Proc. Soc. Exp. Biol. Med. 119, 370-376.
18. Stewart, C. L., Stuhlmann. H., Jahner, D. & Jaenisch, R. (1982) Proc. Natl. Acad. Sci. USA 79, 4098-4102.
19. Jahner, D., Sthulmann, H., Stewart, C. L., Harbers, K., Lohler, J., Simon, I. & Jaenisch, R. (1982) Nature (London) 298, 623-628.
20. Niwa, O., Yokota, Y., Ishida, H. & Sugahara, T. (1983) Cell 32, 1105-1113.
21. Candido, E. P. M., Reeves, R. & Davie, J. R. (1978) Cell 14, 105-113.
22. Kaleko, M., Garcia, J. V., Osborne, W. R. A. & Miller, A. D. (1990) Blood 75, 1733-1741.
23. Osborne. W. R. A., Hock, R. A., Kaleko, M. & Miller, A. D. (1990) Hum. Gene Ther. 1, 31-41.
24. Linney, E., Davis, B., Overhauser, J., Chao, E. & Fan, H. (1984) Nature (London) 308, 470-472.
25. Franz, T., Hilberg, F., Seliger, B., Stocking, C. & Ostertag, W. (1986) Proc. Natl. Acad. Sci. USA 83, 3292-3296.
26. Barklis, E., Mulligan, R. C. & Jaenisch, R. (1986) Cell 47, 391-399.
27. Hilberg, F., Stocking, C., Ostertag, W. & Gretz, M. (1987) Proc. Natl. Acad. Sci. USA 84, 5232-5236.
28. Weiher, H., Barklis, E., Ostertag, W. & Jaenisch, R. (1987) J. Virol. 61, 2742-2746.