Novel, Potent Aldose Reductase Inhibitors: 3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalazineacetic Acid (Zopolrestat) and Congeners

Journal of Medicinal Chemistry

Volumn 34, Issue 1, 1991, Pages 108-122

  Mylari, Banavara L ^a   Larson, Eric R ^a   Zembrowski, William J ^a   Dee, Michael F ^a   Singleton, David H ^a   Beyer, Thomas A ^a   Aldinger, Charles E ^a   Siegel, Todd W ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; PHTHALAZINE DERIVATIVE; PONALRESTAT; SORBINIL; SORBITOL; TOLRESTAT; ZOPOLRESTAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CRYSTALLOGRAPHY; DIABETES MELLITUS; DRUG ABSORPTION; DRUG SYNTHESIS; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; LENS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PLACENTA; PRIORITY JOURNAL; RAT; RETINA; REVIEW; SCIATIC NERVE; STRUCTURE ACTIVITY RELATION;

ALDEHYDE REDUCTASE; ANIMAL; COMPARATIVE STUDY; ENZYME INHIBITORS; FEMALE; HUMAN; INDICATORS AND REAGENTS; KINETICS; LENS, CRYSTALLINE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHTHALAZINES; PLACENTA; PREGNANCY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; X-RAY DIFFRACTION;

EID: 0025967888     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00105a018     Document Type: Article

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