Proteases and their inhibitors: today and tomorrow

Biochimie

Volumn 73, Issue 1, 1991, Pages 121-126

  Scharpe, S ^a   De Meester, I ^a   Hendriks, D ^a,b   Vanhoof, G ^a   van Sande, M ^a   Vriend, G ^b  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

angiotensin converting enzyme; hirudin; HIV 1 protease; hypertension; renin; thrombin; transition state mimetics

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HIRUDIN; PROTEINASE INHIBITOR; RENIN; RENIN INHIBITOR; THROMBIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CONFERENCE PAPER; HUMAN IMMUNODEFICIENCY VIRUS 1; HYPERTENSION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMAL; ENDOPEPTIDASES; HEPARIN; HIRUDIN; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMAN; MOLECULAR SEQUENCE DATA; PEPTIDYL-DIPEPTIDASE A; PIPECOLIC ACIDS; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; RENIN; THROMBIN;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA;

EID: 0025964519     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/0300-9084(91)90084-E     Document Type: Article

References (40)

1. The signal transduction induced by thrombin in human platelets
2. Biology of recombinant hirudin (CGP-39393) a new prospect in the treatment of thrombosis
3. Biochemistry and genetic engineering of hirudin
4. Pharmacological survey of recombinant hirudin
5. Pharmacokinetics and pharmadynamics of hirudin in man after single subcutaneous and intravenous bolus administration
6. Structure and functions of human angiotensin I converting enzyme (kininase II)
7. Novel activity of angiotensin-converting enzyme
8. Distribution of angiotensin converting enzyme in human tissues
9. Kininase II of human seminal fluid: kinetics and inhibition
10. Enzymes and isoenzymes involved in the release of vasoactive peptides
11. Comparison in vitro ex vivo and in vivo of the action of seven structurally diverse inhibitors of angiotensin converting enzyme
12. Hoe288: Indications on the memory-enhancing effects of a peptidase inhibitor
13. Angiotensin converting enzyme inhibitors: animal experiments suggest a new pharmacological treatment for alcohol abuse in humans
14. Novel activity of human angiotensin 1 converting enzyme: release of the NH2- and COOH-terminal tripeptides from the luteinizing hormone-releasing hormone
15. Viral proteinases
16. Is prorenin of physiological and clinical significance?
17. Genetic engineering and the serpins
18. Renin inhibitors
19. Why renin inhibitors?
20. Human inhibitors containing an unnatural amino acid, norstatine
21. Systemic and renal hemodynamic effects of renin or angiotensin converting enzyme inhibition in non-human primates
22. Effects of a specific and long-acting renin-inhibitor in the marmoset
23. A new class of orally active renin inhibitors containing phenyllactic acid at P3
24. The molecular biology of the human immunodeficiency virus
25. Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1
26. Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues
27. Inhibition of HIV replication in cell culture by the specific aspartic protease inhibitor pepstatin A
28. Human immunodeficiency aspartic protease
29. HIV-1 aspartic protease: high-level production and automated fluorometric screening of inhibitors
30. Enzymatic activity of a synthetic 99 residue protein corresponding to the putative HIV-1 protease
31. Chemical synthesis and enzymatic activity of a 99-residue peptide with a sequence proposed for the human immunodeficiency virus protease
32. Inhibition of human immunodeficiency virus l protease in vitro: rational design of substrate analogue inhibitors
33. A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation
34. Rational design of peptide-based HIV proteinase inhibitors
35. What if: a molecular modeling and drug design program
36. Solution structure of recombinant hirudin and Lys-47 → Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study