Comparisons of tetrachloro(d,l-trans)1,2-diaminocyclohexaneplatinum(IV) biotransformations in the plasma of Fischer 344 rats at therapeutic and toxic doses

Cancer Chemotherapy and Pharmacology

Volumn 27, Issue 5, 1991, Pages 335-341

  Carfagna, Patrick F ^a   Poma, Allen ^b   Wyrick, Steven D ^a   Holbrook, David J ^b   Chaney, Stephen G ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TETRAPLATIN;

ANIMAL EXPERIMENT; ARTICLE; DRUG METABOLISM; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; ANTINEOPLASTIC AGENTS; BIOTRANSFORMATION; COMPARATIVE STUDY; MALE; ORGANOPLATINUM COMPOUNDS; RATS; RATS, INBRED F344; SUPPORT, NON-U.S. GOV'T; TIME FACTORS;

EID: 0025964202     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/BF00688854     Document Type: Article

References (28)

1. Exacerbation of cisplatin-induced nephrotoxicity by methionine
2. Synthesis, physical properties, and antitumor activity of tetraplatin and related tetrachloroplatinum(IV) steroisomers of 1,2-diaminocyclohexane
3. Comparison of the effectivity of two diaminocyclohexane Pt-complexes
4. l-Methionine suppresses pathological sequelae of cis-platinum in the rat
5. Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues
6. Biochemical modulation of cisplatin toxicity
7. Reduction of tetrachloro(d,l- trans)1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) toxicity by the administration of diethyldithiocarbamate (DDTC),S-2(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) or sodium selenite in the Fischer 344 rat
8. In vitro biotransformations of tetrachloro(d,l- trans)1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) in rat plasma
9. Studies on the antitumor activity of group VIII transition metal complexes: I. Platinum(II) complexes
10. Cisplatin metabolites in plasma, a study of their pharmacokinetics and importance in the nephrotoxicity and antitumor activity of cisplatin
11. Rapid reduction of tetrachloro(d,l- trans)1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) in RMPI 1640 tissue culture medium
12. Platinate toxicity: past, present, and prospects
13. Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes
14. [195mPt]-and [15N]-NMR studies of antitumor complexes
15. Cisplatin
16. Cisplatin: chemistry, distribution and biotransformation
17. High-performance liquid chromatographic separation of platinum complexes containing the cis-1,2-diaminocyclohexane carrier ligand
18. Intracellular biotransformations of platinum compounds with the 1,2-diaminocyclohexane carrier ligand in the L121- cell line
19. Displacement of the bidentate malonate ligand from (d.l, trans)1,2-diaminocyclohexane)malonatoplatinum(II) by physiologically important compounds in vitro
20. Intracellular metabolites of cisplatin in the rat kidney
21. Therapeutic and pharmacological studies of tetrachloro(d,l. trans)1,2-diaminocyclohexanplatinum(IV) (tetraplatin), a new platinum analog
22. Comparative toxicity and renal distribution of the platinum analogs tetraplatin, CHIP, and cisplatin at equimolar doses in the Fischer 344 rat
23. In vitro biochemical indices of nephrotoxicity of platinum analogs tetraplatin, CHIP, and cisplatin in the Fischer 344 rat
24. Preclinical testing of some cisplatin congeners as potential anticancer agents
25. Interactions of platinum compounds with biological molecules
26. Evaluation of trans-tetrachloro-1,2-diaminocyclohexaneplatinum(IV) in murine leukemia L1210 resistant and sensitive to cis-diamminedichloroplatinum(II)
27. Tritiated platinum antitumor agents containing the trans-(d,l)-1,2-diaminocyclohexane carrier ligand
28. Synthesis of [195mPt]-tetraplatin