Interaction of indomethacin with low molecular weight chitosan, and improvements of some pharmaceutical properties of indomethacin by low molecular weight chitosans

International Journal of Pharmaceutics

Volumn 67, Issue 1, 1991, Pages 11-20

  Imai, Teruko ^a   Shiraishi, Sumihiro ^a   Saitô, Hazime ^b   Otagiri, Masaki ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Complexation; Enhanced absorption rate; Enhanced dissolution; Indomethacin; Interaction; Low molecular weight chitosan

Indexed keywords

CHITOSAN; DRUG CARRIER; INDOMETACIN;

ANIMAL EXPERIMENT; ARTICLE; COMPLEX FORMATION; DISPERSION; DISSOLUTION; DOG; DRUG ABSORPTION; DRUG SOLUBILITY; INTRAMUSCULAR DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0025963969     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(91)90260-U     Document Type: Article

References (16)

1. Solid state NMR of linear and cyclic peptides
2. Phase solubility techniques
3. Influence of egg albumin on dissolution of several drugs
4. Physicochemical characterization of indomethacin polymorphs and the transformation kinetics in ethanol
5. Novel method for the preparation of controlled-release theophylline granules coated-with a poly electrolyte complex of sodium polyphosphate-chitosan
6. Crystal and molecular structure of an antiinflammatory agent, indomethacin, 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
7. Rotational barrier of benzaldehyde as determined by C-13 NMR spectroscopy
8. The use of chitin and chitosan as drug carriers
9. A kinetic study of the crystallization process of noncrystalline indomethacin under isothermal conditions
10. Transverse relaxation of dipolar coupled spin systems under r.f. irradiation: detecting motions in solids
11. 13C chemical shifts
12. Dissolution properties and bioavailability of phenytoin from ground mixtures with chitin or chitosan
13. Enhancement of dissolution rates of several drugs by low-molecular chitosan and alginate
14. Carbon-13 nuclear magnetic resonance spectra of anti-in-flammatory drugs: phenylbutazone, oxyphenbutazone and indomethacin
15. Slow molecular motion detected in the NMR spectra of rotating solids
16. Resolution in carbon-13 NMR of organic solids using high-power proton decoupling and magic-angle sample spinning