Double-blind placebo-controlled trial of flunarizine as add-on therapy in refractory childhood epilepsy

Brain and Development

Volumn 13, Issue 4, 1991, Pages 217-222

  Battaglia, Agatino ^a   Ferrari, Anna Rita ^a   Guerrini, Renzo ^a  

^a DEPARTMENT OF DEVELOPMENTAL NEUROSCIENCE   (Italy)

Author keywords

add on therapy; controlled trial; FLN; refractory childhood epilepsy

Indexed keywords

ANTICONVULSIVE AGENT; FLUNARIZINE; PLACEBO;

ADOLESCENT; ADULT; ARTICLE; BENIGN CHILDHOOD EPILEPSY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG BLOOD LEVEL; DRUG RESISTANCE; ELECTROENCEPHALOGRAPHY; FEMALE; FOCAL EPILEPSY; GENERALIZED EPILEPSY; HEMATOLOGY; HUMAN; LENNOX GASTAUT SYNDROME; LIVER FUNCTION TEST; MALE; MYOCLONUS EPILEPSY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

EID: 0025955601     PISSN: 03877604     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0387-7604(12)80052-0     Document Type: Article

References (39)

1. Flunarizine
2. Absorption and tissue distribution of flunarizine in rats, pigs and dogs
3. Steady-state plasma levels of flunarizine in chronically treated patients
4. A double-blind placebo controlled cross-over evaluation of a constant-dose schedule
5. Pharmacological protection against brain hypoxia: the efficacy of flunarizine, a calcium entry blocker
6. The antimigrainous pharmacology of flunarizine (R 14950), a calcium antagonist
7. A double-blind placebo-controlled prophylactic study of flunarizine (Sibelium) in migraine
8. Flunarizine, a calcium channel blocker, in the prophylaxis of migraine
9. Flunarizine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use
10. Flunarizine, a calcium entry blocker, in migraine prophylaxis
11. Flunarizine in alternating hemiplegia in childhood
12. Paroxysmal alternating hemiplegia of childhood: treatment with flunarizine and other agents
13. Anticonvulsant properties of cinnarizine and flunarizine in rats and mice
14. Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO-15-1788, Picrotoxin and DMBB
15. Behavioral analysis of the effects of 15 anticonvulsants in the amygdaloid kindled rat
16. Behavioural analysis of amygdaloid kindling in beagle dogs and the effects of clonazepam, diazepam, phenobarbital, diphenylhydantoin and flunarizine on the seizure manifestation
17. Anticonvulsant properties of flunarizine on reflex and generalized models of epilepsy
18. Double-blind study of the effectiveness of flunarizine in therapy resistant epilepsy in mentally retarded children (abstract)
19. Double-blind placebo-controlled trial of flunarizine as add-on therapy in epilepsy
20. Open dose-ranging trial of flunarizine as add-on therapy in epilepsy
21. Ineffectiveness of add-on treatment with flunarizine in patients with epilepsy and mental retardation: results of a double-blind cross-over study
22. Proposal for revised clinical and electroencephalographic classification of epileptic seizures
23. Proposal for revised classification of epilepsies and epileptic syndromes
24. Sensitive chromatographic method for the determination of cinnarizine and flunarizine in biological samples
25. The use of non-parametric methods in the statistical analysis of the two period change-over design
26. Double-blind placebo-controlled cross-over study of the efficacy of flunarizine as add-on therapy in epilepsy
27. Double-blind cross-over placebo-controlled study of flunarizine in patients with therapy resistant epilepsy
28. Clinical approach to the management of intractable epilepsy
29. Intractable epilepsy: introduction
30. Pharmacopsychological effects of flunarizine in geriatric patients win light brain organic psycho-syndrome
31. Flunarizine in mentally retarded children with therapy-resistant epilepsy
32. Add-on therapy in epilepsy with calcium entry blockers
33. Pharmacokinetic profile of flunarizine after single and multiple dosing in epileptic patients receiving comedication
34. Double-blind placebo-controlled trial of flunarizine in therapy resistant epileptic patients
35. Double-blind placebo-controlled evaluation of flunarizine as adjunct therapy in epilepsy with complex partial seizures
36. Flunarizine as a supplementary medication in refractory childhood epilepsy: a double-blind cross-over study
37. Flunarizine as add-on therapy in epilepsy
38. Flunarizine in epilepsy: a worthwhile therapy?