The role of neuronal calcium channels in dependence on ethanol and other sedatives/hypnotics

Pharmacology and Therapeutics

Volumn 50, Issue 3, 1991, Pages 347-365

  Little, H J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; ALCOHOL; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CHLORDIAZEPOXIDE; FLUNARIZINE; ISRADIPINE; MORPHINE; NIFEDIPINE; NIMODIPINE; NITRENDIPINE; OPIATE; VERAPAMIL;

ALCOHOL TOLERANCE; ALCOHOLISM; ANIMAL MODEL; ANIMAL TISSUE; DRUG DEPENDENCE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; SNAIL; WITHDRAWAL SYNDROME;

ALCOHOLISM; ANIMAL; BARBITURATES; BENZODIAZEPINES; BINDING SITES; CALCIUM CHANNELS; DIHYDROPYRIDINES; ETHANOL; HUMAN; NARCOTICS; NEURONS; SUPPORT, NON-U.S. GOV'T;

EID: 0025955597     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(91)90050-V     Document Type: Article

References (176)

1. Dihydropyridine sensitive low-threshold calcium channels in isolated rat hypothalamic neurones
2. Ethanol-induced disordering of membranes from different age groups of C57 BL/6 NN1A mice
3. Effects of peripheral and central administration of calcium channel blockers in the naloxone-precipitated abstinence syndrome in morphine-dependent rats
4. Differential effects of calcium channel blockers and stimulants on morphine withdrawal in vitro
5. Nitrendipine block of cardiac calcium channels: high affinity binding to the inactivated state
6. Verapamil induced behavioural, autonomic and motor effects in cats
7. Pharmacological evidence that the nonneuronal diazepam binding site in primary cultures of glial cells is associated with a calcium channel
8. Potentiation of thermoregulatory and analgesic effects of morphine by calcium antagonists
9. Ethanol suppresses hippocampal cell firing through a calcium and cyclic AMP-sensitive mechanism
10. Acute ethanol and acetaldehyde administration produce similar effects of L-type calcium channels in rat brain
11. Differential effects of the benzodiazepine antagonist Ro 15-1788 after “general anaesthetic” doses of benzodiazepines in mice
12. Barbiturate inhibition of calcium uptake by depolarized nerve terminals in vitro
13. Calcium channel inhibitors suppress the morphine-withdrawal syndrome in rats
14. Second messengers involved in genetic regulation of the number of calcium channels in bovine adrenal chromaffin cells in culture
15. Membrane receptors involved in upregulation of calcium channels in bovine adrenal chromaffin cells, chronically exposed to ethanol
16. The alcohol withdrawal syndrome
17. Interaction of calcium channel blockers with nonneuronal benzodiazepine binding sites
18. Ethanol in low doses augments calcium-mediated mechanisms measured intracellularly in hippocampal neurones
19. +-conductance
20. + conductance: a possible common mechanism for sedative-hypnotic drug action
21. Benzodiazepines both enhance gamma-aminobutyrate responses and decrease calcium action potentials in guinea pig myenteric neurones
22. Effect of low concentrations of ethanol on the fluidity of spin labeled erythrocyte and brain membranes
23. Drug tolerance in biomembranes: a spin label study of the effects of ethanol
24. Calcium channel antagonists increase morphine induced analgesia and antagonise morphine tolerance
25. Ethyl-betacarboline carboxylase lowers seizure threshold and antagonises flurazepam-induced sedation in rats
26. Morphine inhibition of calcium fluxes neurotransmitter release and protein and lipid phosphorylation in brain slices and synaptosomes
27. Neuronal intracellular calcium are altered by anesthetics: relationship to membrane fluidisation
28. Effect of chronic ethanol treatment and selective breeding for hypnotic sensitivity to ethanol on intracellular ionised calcium concentrations in synaptosomes
29. Ethanol and inositol 1,4,5, triphosphate release calcium from separate stores of brain microsomes
30. Effect of ethanol on intracellular ionised calcium concentrations in synaptosomes and hepatocytes
31. Ethanol increases synaptosomal free calcium
32. Mechanism of action of ethanol; initial central nervous system actions
33. 2+ currents in hippocampal CA1 neurones of the guinea pig in vitro
34. Augmentation by calcium channel antagonists of general anaesthetic potency in mice
35. Are changes in neuronal calcium channels involved in ethanol tolerance
36. Increased dihydropyridine sensitive calcium channels in rat brain may underlie ethanolo physical dependence
37. Effects of the calcium channel agonist, BAY K 8644, on a general anaesthetic potency in mice
38. Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine
39. Evidence for the involvement of dihydropyridine-sensitive calcium channels in ethanol dependence
40. Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs
41. Differential interactions between benzodizepines and the dihydropyridines nitrendipine and Bay K 8644
42. Nimodipine's interactions with other drugs: II, diazepam
43. Decreased neuronal inhibition in vitro after long-term administration of ethanol
44. Dietary manipulation of alcohol withdrawal in the rat
45. Withdrawal symptoms and alcohol dependence: fruitful mysteries
46. Acute and chronic effects of barbiturates on depolarisation induced calcium influx into synaptosomes from rat brain regions
47. Development of ethanol tolerance in sensory neurones in culture
48. Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat
49. Comparative actions of phenytoin and other anticonvulsant drugs on potassium- and veratridine-stimulated calcium uptake in synaptosomes
50. Effects of acute and chronic ethanol administration on whole mouse brain synaptosomal calcium influx
51. 3H]-nimodipine receptor binding in rat brain regions
52. 3H]-nimodipine receptor binding in rat brain region
53. The effect of chronic administration of ethanol on startle threshold in rats
54. Relationship of alcohol dose to intensity of alcohol withdrawal signs in mice
55. The alcohol withdrawal syndrome. A view from the laboratory
56. Alcohol dependence produced in mice by inhalation of ethanol: grading the withdrawal reaction
57. 3H] PN 200-110, to intact cultured PC12 cells
58. 2+ channel modulating drugs
59. Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion cells in cell culture
60. Barbiturates and nifedipine have different and selective effects on calcium currents of mouse DRG neurones in culture: a possible basis for differing clinical actions
61. Two components of long-term potentiation induced by different patterns of afferent activation
62. Effect of morphine on calcium-uptake by lysed synaptosomes
63. Barbiturates depress currents through human brain calcium channels studied in Xenopus oocytes
64. 3H]-dihydropyridine binding sites in brain, heart and smooth muscle of ethanol dependent rats
65. Altered characteristics of catecholamine release from rat cortical slices and bovine adrenal chromaffin cells in culture after chronic exposure to ethanol and the effect of the dihydropyridine drugs on these systems
66. Genetic upregulation of calcium channels in a cellular model of ethanol dependence
67. Ethanol and pentobarbital inhibition of intrasynaptosomal sequestration of calcium
68. Differential effects of membrane pertubants on voltage activated sodium and calcium channels and calcium dependent potassium channels
69. Ethanol and synaptosomal calcium binding
70. Inhibition of synaptosomal calcium uptake by ethanol
71. Effects of a sedative and a convulsant barbiturate on synaptosomal calcium transport
72. Discrete changes in brain calcium with morphine analgesia, tolerance-dependence, and abstinence
73. Relationship of membrane physical properties to alcohol dependence in mice selected for genetic differences in alcohol withdrawal
74. 3H]-nitrendipine binding and calcium and sodium fluxes in brain
75. Effects of ethanol and calcium on lipid other of membranes from mice selected for genetic differences in ethanol intoxication
76. Barbiturate reduction of calcium-dependent action potentials: correlation with anaesthetic action
77. 2+ channels in evoked release of norepinephrine from sympathetic neurones
78. Acute CGS8216 reverses, and concurrent verapamil prevents, diazepam withdrawal-induced anxiety in rats
79. Calcium and agonists and antagonists of the dihydropyridine type: antinociceptive effects; interference with opiate μ-receptor agonists and pharmacological effect in rodents
80. Selective antagonists of benzodiazepine receptors
81. Nimodipine interactions with other drugs, 1. Ethanol
82. Calcium channel blocking agent in the treatment of acute alcohol withdrawal. Caroverine versus meprobamate in a randomized double blind study
83. The ethanol sensitivity of calcium taken up by a depolarisation-dependent process in mouse strains DBA and C57BL
84. Effect of L-tryptophan on the acquisition of tolerance to ethanol-induced motor impairment and hypothermia
85. Effects of chlordiazepoxide on depolarisation induced calcium influx into synaptosomes
86. Acute and chronic effects of barbiturates on depolarisation induced calcium influx into rat synaptosomes
87. Inhibition of fast and slow phase depolarisation dependent synaptosomal calcium uptake by ethanol
88. The feeding of alcohol in liquid diets; two decades of applications and 1982 uptake
89. Ethanol potentiates and blocks NMDA activated single-channel currents in rat hippocampal pyramidal cells
90. Possible mechanisms that may underlie the behavioural effects of ethanol
91. Lack of tolerance to ethanol after concurrent administration of nitrendipine
92. Calcium channel antagonists decrease the ethanol withdrawal syndrome
93. Effects of dihydropyridine calcium channel antagonists in ethanol withdrawal; doses required, stereospecifivity and actions of BAY K 8644
94. The intrinsic electrophysiological properties of mammalian neurones: insights into central nervous system function
95. Specific blockage of the low threshold calcium channel by high molecular weight alcohols
96. Ethanol inhibits NMDA activated ion currents in hippocampal neurones
97. Ethanol administration in vivo alters calcium ions control in rat straitum
98. Effects of ethanol on calmodulin levels in mouse striatum and cerebral cortex
99. 2+ sensitivity
100. Anticonvulsant and anaesthetic barbiturates: different postsynaptic actions in cultured mammalian neurones
101. Induction of physical dependence upon ethanol and the associated behavioural changes in the rat
102. Anatomy of CNS opioid receptors
103. Comparative effects of chronic exposure to ethanol and calcium channel antagonists on calcium antagonists receptors in cultured neural (PC12) cells
104. 2-amino-7-phosphonohepatanic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats
105. Anticonvulsant activity of several excitatory amino acid antagonists against barbital induced spontaneous convulsions
106. Increased response of cerebellar cGMP to kainate but not NMDA or quisqualate following barbital withdrawal from dependent rats
107. A review of methods to induce alcohol addiction in animals
108. Nifedipine blocks sleep induction by flurazepam in the rat
109. 2+: reversal by dihydropyridine calcium channel antagonists
110. Ethanol regulates calcium channels in clonal neural cells
111. Calcium binding to brain synaptosomes, effects of chronic ethanol intake
112. Differential effects of ethanol on two synaptic membrane calcium transport systems
113. 2+ exchange activity
114. Voltage-dependent block of excitatory amino acid currents by pentobarbital
115. Pentobarbital: presynaptic effect in squid giant synapse
116. The effects of pentobarbital and related compounds on frog motoneurons
117. Reversed ethanol effects on potassium conductances in aged hippocampal dentate granule neurones
118. Barbiturates increased the rate of voltage-dependent inactivation of the calcium current in snail neurones
119. Three types of neuronal calcium channel with different calcium agonist sensitivity
120. Unusual interactions of benzodiazepine receptor antagonists
121. Electrophysiological effects of acute ethanol exposure. II. Alterations in the calcium component of action potentials from sensory neurons in dissociated culture
122. A comparison of techniques to induce alcohol dependence and tolerance in the mouse
123. 2+ entry pathways in neuronal preparations
124. Decrease in analgesic effect of nifedipine following chronic administration of morphine
125. 3H]-nitrendipine binding and gamma-aminobutyric acid release in rat hippocampus following repeated morphine administration
126. GABA-benzodiazepine-barbiturate receptor interactions
127. Cerebral alteration in calmodulin levels associated with the induction of physical dependence upon ethanol in rats
128. Evidence for down regulation of 3H-nitrendipine recognition sites in mouse brain about long term treatment with nifedipine or verapamil
129. 2+ channel antagonists in the modulation of hypothermia
130. Different effect of diltiazen and nifedipine on some central actions of ethanol in the rat
131. Increased action of the partial inverse agonist, FG 7142, during barbiturate withdrawal; protective effect of the calcium channel antagonist, nitrendipine
132. Changes in dihydropyridine binding in the cerebral cortex following chronic barbital treatment
133. An NMDA antagonist protects against the barbiturate withdrawal syndrome, but does not appear to cause cross-tolerance
134. 3H]-nimodipine binding sites in rat brain
135. Prolonged morphine treatment increase rat brain dihydropyridine binding sites: possible involvement in development of dependence
136. Optical imaging of calcium accumulation in hippocampal pyramidal cells during synaptic activation
137. Ethanol tolerance in hippocampal neurones: adaptive changes in cellular responses to ethanol measured in vivo
138. Body temperature in mice: A quantitative measure of alcohol tolerance and physical dependence
139. Acute ethanol effect on calcium antagonist binding in rat brain
140. Molecular aspects of calcium-membrane interactions: a model for cellular adaptation to ethanol
141. 2+ uptake in synaptosomal membranes
142. Nerve cell calcium as a messenger for opiate and endorphin actions
143. Morphine and ethanol: selective depletion of regional brain calcium
144. 2+ receptor sites after chronic ethanol exposure
145. 3H]-nitrendipine binding following chronic treatment with morphine
146. 2+ channels in nerve cell bodies of corpus striatum
147. Blocking action of pentobarbital on receptors for excitatory amino acids in the guinea pig hippocampus
148. Modulation of neuronal T-type calcium channel currents by photoactivation of intracellular guanosine 5′-o(3-thio) triphosphate
149. Spontaneous calcium release induced by ethanol in the isolated rat brain microsomes
150. Ethanol tolerance and enhanced calcium/calmodulin dependent phosphorylation of synaptic membrane proteins
151. Effects of ethanol on CA1 and CA3 pyramidal cells in the hippocampal slice preparation: an intracellular study
152. Diazepam and its analogous p-chloro derivative, Ro 5-4864. Comparative effects on mouse neurones in cell culture
153. Calcium antagonist subgroups
154. Benzodiazepine receptors in rat brain
155. Do calcium channel classifications account for neuronal calcium channel diversity
156. Interactions between verapamil and morphine on physiological parameters in rats
157. Micromolar affinity benzodiazepine receptors regulate voltage-sensitive calcium channels in nerve terminals
158. Hippocampal CA1 pyramidal cells of rats have four voltage-dependent calcium conductances
159. Barbiturates, alcohols and the CNS excitatory transmission: specific effects on the kainate and quisqualate receptors
160. Molec. Pharmac.
161. Multiple types of neuronal calcium channels and their selective modulation
162. Block of calcium channels by enkephalin and somatostatin in neuroblastoma-glioma hybrid NG108-15 cells
163. Alteration in calcium binding activity in synaptosomal membranes from rat brains in association with physical dependence upon ethanol
164. Excitatory amino acid transmitters
165. Ethanol tolerance in the rat is learned
166. Barbiturates decrease voltage dependent calcium conductance of mouse neurons in dissociated cell cultured
167. Clustering of L-type calcium channels at the base of major dendrites in hippocampal pyramidal neurones
168. Chronic ethanol increases excitability and hippocampal cell bodies; effects decreased by chronic nitrendipine treatment
169. Patterns of changes in field potentials in the isolated hippocampal slice on withdrawal from chronic ethanol treatment of mice in vivo
170. A calcium channel antagonists stereoaselectively decreases ethanol withdrawal hyperexcitability, but not due to bicuculline, in hippocampal slices
171. Nitrendipine, given during drinking, decreases the electrophysiological changes in the isolated hippocampal slice, seen during ethanol withdrawal
172. Chronic dihydropyridine treatment can reverse the behavioural consequences and prevent adaptations to chronic ethanol
173. Nifedipine delays the acquisition of ethanol tolerance
174. The k-opiate agonist U50488H decreases the entry of 45Ca into rat cortical synaptosomes by inhibiting N- but not L-type calcium channels
175. Effects of acute and chronic morphine treatments on calcium localization and binding in brain