Actions of d-cycloserine at the N-methyl-d-aspartate-associated glycine receptor site in vivo

Neuropharmacology

Volumn 30, Issue 11, 1991, Pages 1167-1171

  Emmett, M R ^a   Mick, S J ^a   Cler, Julie A ^a   Rao, T S ^a   Iyengar, S ^a   Wood, P L ^a  

^a MONSANTO COMPANY   (United States)

Author keywords

cerebellum; cGMP; d cycloserine; glycine; NMDA

Indexed keywords

CYCLIC GMP; CYCLOSERINE; GLYCINE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PENTETRAZOLE; SERINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMAL; CEREBELLUM; CYCLIC GMP; CYCLOSERINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCINE; INJECTIONS, SUBCUTANEOUS; MALE; MICE; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, NEUROTRANSMITTER;

EID: 0025949567     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(91)90161-4     Document Type: Article

References (15)

1. Mechanisms by which diazepam muscimol and other drugs change the content of cGMP in cerebellar cortex
2. The role of NMDA receptors in learning and memory
3. NMDA receptors-their role in long-term potentiation
4. Excitatory amino acids in the brain. Focus on NMDA receptors
5. dCycloserine: a ligand for the N-methyl-d-aspartate coupled glycine receptor has partial agonist characteristics
6. Radioligand binding to central phencyclidine recognition sites is dependent on excitatory receptor agonists
7. d-Cycloserine, a positive modulator of the N-methyl-d-aspartate receptor, enhances performance of learning tasks in rats
8. Ethyl-β-carboline-3-carboxylate antagonizes the action of GABA and benzodiazepines in the hippocampus
9. Multiple sites for the regulation of the N-methyl-d-aspartate receptor
10. d-Cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes
11. Antagonism of N-methyl-d-aspartate (NMDA) evoked increases in cerebellar cGMP and striatal ACh release by phencyclidine (PCP) receptor agonists: Evidence for possible allosteric coupling of NMDA and PCP receptors
12. In vivo modulation of the N-methyl-d-aspartate receptor complex by d-serine: Potentiation of ongoing neuronal activity as evidenced by increased cerebellar cyclic GMP
13. Antagonism of agonist actions at NMDA and NMDA-associated glycine receptors in mouse cerebellum: Studies of HA-966
14. In vivo cerebellar cGMP response: A model system for studies of the NMDA-associated glycine receptor