An overview of γ-hydroxybutyrate catabolism: The role of the cytosolic NADP+-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway

Neurochemical Research

Volumn 16, Issue 9, 1991, Pages 965-974

  Kaufman, Elaine E ^a   Nelson, Thomas ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYBUTYRIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; OXIDOREDUCTASE;

ANIMAL TISSUE; MAMMAL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ALCOHOL OXIDOREDUCTASES; ANIMAL; CARBOHYDRATE DEHYDROGENASES; CARBON; CATALYSIS; CYTOSOL; GAMMA-AMINOBUTYRIC ACID; HYDROXYBUTYRATE DEHYDROGENASE; KETOGLUTARIC ACIDS; KINETICS; MITOCHONDRIA; OXIDATION-REDUCTION; SODIUM OXYBATE;

ANIMALIA; MAMMALIA;

EID: 0025944441     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/BF00965839     Document Type: Article

References (41)

1. Natural occurrence of gamma-hydroxybutyrate in mammalian brain
2. Formation and regional distribution of γ-hydroxybutyric acid in mammalian brain
3. The extraneural distribution of γ-hydroxybutyrate
4. A neurophysiological comparison of gamma-hydroxybutyrate with phenobarbital in cats
5. Effects of γ-butyrolactone on local cerebral glucose utilization in the rat
6. Mechanism of the gamma-hydroxybutyrate induced increase in brain dopamine and its relationship to ‘sleep’
7. Résumé d'une étude expérimental et clinique sur un substrat métabolique a action centrale inhibitrice le 4-hydroxybutyrate de Na
8. Effect of low dose γ-butyrolactone therapy on forebrain neuronal ischemia in the unrestrained, awake rat
9. The protective effect of γ-hydroxybutyrate in regional intestinal ischemia in the hamster
10. Stimulatory effects of γ-hydroxybutyric acid on growth hormone and prolactin release in humans
11. Studies of gamma-aminobutyric acid (GABA) and its metabolite on the control mechanism of secretion of anterior pituitary hormones. II. Effects of gamma-hydroxybutyric acid (GHB) on secretion of anterior pituitary hormones in human subjects
12. Pyretic action of low doses of γ-hydroxybutyrate in rats
13. Neurobiology. γ-Hydroxybutyrate, a putative neurotransmitter in the central nervous system
14. Metabolism of gamma-hydroxybutyric acid
15. gamma-Hydroxybutyrate degradation in the brain in vivo: Negligible direct conversion to GABA
16. Metabolism of [1-14C]γ-hydroxybutyric acid by rat brain after intraventricular injection
17. Urinary excretion of gamma-hydroxybutyric acid in a patient with neurological abnormalities. The probability of a new inborn error of metabolism
18. Succinic semialdehyde dehydrogenase deficiency: An inborn error of gamma-aminobutyric acid metabolism
19. Purification and characterization of an NADP+-linked alcohol oxido-reductase which catalyzes the interconversion of γ-hydroxybutyrate and succinic semialdehyde
20. Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria
21. TPN-L-gulonate dehydrogenase
22. Purification and characterization of four NADPH-dependent aldehyde reductases from pig brain
23. Kinetics of coupled γ-hydroxybutyrate oxidation and D-glucuronate reduction by an NADP+-dependent oxidoreductase
24. Regulation and properties of an NADP+ oxidoreductase which functions as a γ-hydroxybutyrate dehydrogenase
25. Evidence for a role of high Km aldehyde reductase in the degradation of endogenous γ-hydroxybutyrate from rat brain
26. Inhibition of bovine brain aldehyde reductase by anticonvulsant compounds in vitro
27. Effects of the anticonvulsant sodium valproate on γ-aminobutyrate and aldehyde metabolism in ox brain
28. Evidence for the participation of a cytosolic NADP+-dependent oxidoreductase in the catabolism of γ-hydroxybutyrate in vivo
29. Oxidation of γ-hydroxybutyrate to succinic semialdehyde by a mitochondrial pyridine nucleotide-independent enzyme
30. Effect of acute and chronic anticonvulsant administration on endogenous γ-hydroxybutyrate in rat brain
31. myo-Inositol oxygenase from hog kidney: 1. Purification and characterization of an enzyme complex containing the oxygenase and D-glucuronate reductase
32. Gammahydroxybutyric Acid
33. Evidence that a specific succinic semialdehyde reductase is responsible for γ-hydroxybutyrate synthesis in rat brain tissue slices
34. gamma-Hydroxybutyric acid and sleep
35. Content and release of amino-acids and catecholamines in monkey brain
36. Amino acids of brain and γ-hydroxybutyrate-induced depression
37. Conversion of γ-hydroxybutyrate to γ-aminobutyrate in vitro
38. The nature of γ-aminobutyric acid
39. Isolation and characterization of a mammalian hydroxyacid-oxoacid transhydrogenase