Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in parkinson's disease

Annals of Neurology

Volumn 30, Issue 4, 1991, Pages 563-571

  Hattori, Nobutaka ^a   Tanaka, Masashi ^b   Ozawa, Takayuki ^b   Mizuno, Yoshikuni ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME SUBSTRATE COMPLEX; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MITOCHONDRION; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

ADULT; AGED; AGED, 80 AND OVER; CASE REPORT; CYTOCHROME-C OXIDASE; ELECTRON TRANSPORT; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGE; MITOCHONDRIA; MULTIENZYME COMPLEXES; NAD(P)H DEHYDROGENASE (QUINONE); OXIDOREDUCTASES; PARKINSON DISEASE; SUBSTANTIA NIGRA; SUCCINATE DEHYDROGENASE; SUPPORT, NON-U.S. GOV'T; UBIQUINOL-CYTOCHROME-C REDUCTASE;

EID: 0025942723     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.410300409     Document Type: Article

References (35)

1. Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys
2. +, inhibit mitochondrial NADH‐ubiquinone oxidoreductase activity
3. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase
4. Inhibition of mitochondrial alphaketoglutarate dehydrogenase by 1‐methyl‐4‐phenylpyridinium ion
5. Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease
6. Postmortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease
7. Mitochondrial complex I deficiency in Parkinson's disease
8. Mitochondriál complex I deficiency in Parkinson's disease
9. Abnormalities of the electron transport chain in idiopathic Parkinson's disease
10. Immunocytochemical demonstration of cytochrome c oxidase with an immunoperoxidase method
11. Extensive defects of mitochondrial electron‐transfer chain in muscular cytochrome c oxidase deficiency
12. Electron‐transfer complexes of plexes Ascaris suum muscle mitochondria. III. Composition and fumarate reductase activity of complex II
13. Immunocytochemical demonstration of cytochrome c oxidase and complex III in tissues from patients with mitochondrial encephalomyopathy
14. Mitochondrial function in Parkinson's disease
15. Deficient NADH: coenzyme Q oxidoreductase activity in Leber's hereditary optic neuropathy
16. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy
17. Inhibition of NADH‐linked oxidation in brain mitochondria by 1‐methyl‐4‐phenyl‐pyridine, a metabolite of the neurotoxin, 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine
18. Energy‐dependent uptake of N‐methyl‐4‐phenylpyridinium, the neurotoxic metabolite of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine, by mitochondria
19. + metabolite of MPTP, by brain synaptosomes
20. Parkinsonism‐inducing neurotoxin, N‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine: uptake of the metabolite N‐methyl‐4‐phenylpyridine by dopamine neurons explains selective toxicity
21. Melanin affinity of 1‐methyl‐4‐phenyl‐1,2,5,6‐tetrahydropyridine, an inducer of chronic parkinsonism in humans
22. + binds to neuromelanin
23. Presence of tetrahydroisoquinoline and 2‐methyl‐tetrahydroquinoline in parkinsonian and normal human brains
24. Tetrahydroisoquinoline and 1‐methyl‐tetrahydroisoquinoline are present in the human brain: relation to Parkinson's disease
25. An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions
26. N‐Methylisoquinolinium ion as an inhibitor of tyrosine hydroxylase, aromatic L‐amino acid decarboxylase and monoamine oxidase
27. Inhibition of mitochondrial NADH‐ubiquinone oxidoreductase activity and ATP synthesis by tetrahydroisoquinoline
28. Selective inhibition of complex I of the brain electron transport system by tetrahydroisoquinoline
29. Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory‐chain NADH dehydrogenase
30. URF 6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit
31. Repair of pyrimidine dimers in nuclear and mitochondrial DNA of yeast irradiated with low doses of ultraviolet light
32. Normal oxidative damage to mitochondrial and nuclear DNA is extensive
33. Mitochondrial DNA mutations as an important contributor to ageing and degenerative disease
34. Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence