Complexities of the Protein Kinase C Pathway

Molecular Carcinogenesis

Volumn 4, Issue 5, 1991, Pages 339-344

  Blumberg, Peter M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE C;

CARCINOGENESIS; PRIORITY JOURNAL; REVIEW;

ANIMAL; CALCIUM; CARCINOGENS; ENDOPEPTIDASES; ENZYME ACTIVATION; HUMAN; ISOENZYMES; PHORBOL ESTERS; PROTEIN BINDING; PROTEIN KINASE C; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0025939859     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.2940040502     Document Type: Review

References (40)

1. The family of protein kinase C for signal transduction
2. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
3. Hormonal regulation of phosphatidylcholine breakdown
4. The phorbol ester receptor: A phospholipid‐regulated protein kinase
5. Specific receptors for phorbol ester tumor promoters and their involvement in biological responses
6. Zum Wirkungsmechanismus cocarcinogener Pflanzeninhaltsstoffe
7. Tumour‐promoting and hyperplastic effects of phorbol and daphnane esters in CD‐1 mouse skin and a synergistic effect of calcium ionophore with the nonpromoting activator of protein kinase C, sapintoxin A
8. Nonpromoting 12‐deoxyphorbol 13‐esters inhibit induction by phorbol 12‐myristate 13‐acetate of hyperplasia and ornithine decarboxylase in CD‐1 mouse skin
9. Studies on the mechanism of skin tumor promotion: Evidence for several stages in promotion
10. Skin tumor promotion by phorbol esters is a two‐stage process
11. Two‐stage tumor promotion in mouse skin: An alternative interpretation
12. Simple phorbol esters as inhibitors of tumor promotion by TPA in mouse skin
13. Protein kinase C as the receptor for the phorbol ester tumor promoters: Sixth Rhoads Memorial Award Lecture
14. Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor
15. Human brain n‐chimaerin cDNA encodes a novel phorbol ester receptor
16. rac
17. Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells
18. Differentiate action of K252a on protein kinase C and a calcium‐unresponsive, phorbol ester/phospholipid‐activated protein kinase
19. Protein kinase C as a possible receptor protein of tumor‐promoting phorbol esters
20. Activation of protein kinase C by Triton X‐100 mixed micelles containing diacylglycerol and phosphatidylserine
21. Phorbol ester binding to protein kinase C requires a cysteine‐rich zinc finger‐like sequence
22. 3H‐phorbol 12, 13‐di‐butyrate binding to brain
23. Differences in the effects of phorbol esters and diacylglycerols on protein kinase C
24. Structural basis of protein kinase C activation by tumor promoters
25. Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs
26. Influence of side chains on phorbol ester binding to protein kinase C
27. Specificity and mechanism of protein kinase C activation by sn‐1,2‐diacylglycerols
28. Activation and regulation of protein kinase C enzymes
29. Okadaic acid: An additional non‐phorbol‐12‐tetradecanoate‐13‐acetate‐type tumor promoter
30. Phosphatidylinositol‐4,5‐bisphosphate may antecede diacylglycerol as activator of protein kinase C
31. + + dependency of phorbol ester receptors
32. Mechanism of protein kinase C activation by phosphatidylinositol 4,5‐bisphosphate
33. Proteins that bind calcium in a phospholipid‐dependent manner
34. The peptidyl‐prolyl isomerase, FK506‐binding protein, is most likely the 12‐kd endogenous inhibitor 2 of protein kinase C
35. The immunosuppressant FK‐506, like cyclosporins and didemnin B, inhibits calmodulin‐dependent phosphorylation of the elongation factor 2 in vitro and biological effects of the phorbol ester TPA on mouse skin in vivo
36. A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester
37. Effect of microinjected catalytic fragment of protein kinase C on morphological change in Swiss 3T3 cells
38. Mutagenesis of the pseudosubstrate site of protein kinase C leads to activation
39. Distinct mechanisms of regulation of protein kinase C‐epsilon by hormones and phorbol diesters
40. Three distinct forms of rat brain protein kinase C: Differential response to unsaturated fatty acids