Structure and function of inositol triphosphate receptors

Pharmacology and Therapeutics

Volumn 51, Issue 1, 1991, Pages 97-137

  Taylor, Colin W ^a   Richardson, Alan ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; DRUG RECEPTOR; INOSITOL TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE;

PH; PRIORITY JOURNAL; REVIEW; SECOND MESSENGER; STRUCTURE ACTIVITY RELATION;

ANIMAL; HUMAN; RECEPTORS, CELL SURFACE; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0025939170     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(91)90043-L     Document Type: Article

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48. Characterization of stereospecific binding sites for inositol 1,4,5-trisphosphate in airway smooth muscle
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55. Characterization of a membrane protein from brain mediating the inhibition of inositol 1,4,5-trisphosphate receptor binding by calcium
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65. 2+ release channel activity from sarcoplasmic reticulum by annexin VI (67-kDa calcimedin)
66. 4 receptor from cerebellum
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77. Heterogenous inositol tetrakisphosphate binding sites in the adrenal cortex
78. 4 in bovine parathyroid glands
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83. Biochemistry and biphysics of excitation-contraction coupling
84. Characterization of the inositol 1,4,5-trisphosphate-induced calcium release from permeabilised endocrine cells and its inhibition by decavanadate and p-hydroxymercuribenzoate
85. 2+ in parotid acinar cells
86. The structure of calsequestrin in triads of vertebrate skeletal muscle: a deep-etch study
87. 2+ exchanger
88. MgATP-dependent accumulation of calcium ions and inorganic phosphate in liver reticular pool
89. 400 protein in the mouse cerebellum
90. 400
91. Distribution of inositol 1,4,5-trisphosphate receptor mRNA in mouse tissues
92. 2+ in SH-SY5Y neuroblastoma cells
93. 2+ mobilization in SH-SY5Y cells
94. Competitive, reversible, and potent antagonism of inositol 1,4,5-trisphosphate-activated calcium release by heparin
95. GTP-activated communication between distinct inositol 1,4,5-trisphosphate-sensitive and -insensitive calcium pools
96. Calcium signalling mechanisms in endoplasmic reticulum activated by inositol 1,4,5-trisphosphate and GTP
97. 2+ oscillations and for their frequency encoding through protein phosphorylation
98. Evidence that a cerebellum-enriched, synaptic junction glycoprotein is related to fodrin and resists extraction with triton in a calcium-dependent manner
99. 2+ release activities of inositol 1,4,5-trisphosphate in the bovine adrenal cortex
100. Intracellular receptors for inositol 1,4,5-trisphosphate in angiotensin II target tissues
101. Characterization of inositol 1,4,5-trisphosphate receptors and calcium mobilization in hepatic plasma membrane fractions
102. Differential effects of heparin on inositol 1,4,5-trisphosphate binding, metabolism, and calcium release activity in the bovine adrenal cortex
103. Solubilization and partial characterization of inositol 1,4,5-trisphosphate receptor of bovine adrenal cortex reveal similarities with the receptor of rat cerebellum
104. 2,3-Diphosphoglycerate is a non-selective inhibitor of inositol 1,4,5-trisphosphate action and metabolism
105. Purification and characterization of two types of soluble inositol phosphate 5-phosphomonoesterase from rat brain
106. 3
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108. Rapid formation of inositol, 1,3,4,5,-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate
109. Mechanism of the calcium pump in the endoplasmic reticulum of liver: phosphoproteins as reaction intermediates
110. Guanosine 5′-triphosphate releases calcium from rat liver and guinea pig parotid gland endoplasmic reticulum independently of inositol 1,4,5-trisphosphate
111. Inositol 1,4,5-triphosphate and 5′-GTP induced calcium release from different intracellular pools
112. Semisynthetic derivatives of inositol 1,4,5-trisphosphate substituted at the 1-phosphate group: effects on calcium release from permeabilized guinea-pig parotid acinar cells and comparison with binding to aldolase A
113. Heparin inhibits inositol trisphosphate induced calcium release in permeabilised rat liver cells
114. Inhibition of inositol trisphosphate-stimulated calcium mobilization by calmodulin antagonists in rat liver epithelial cells
115. 2+ sequestration in rat liver cells
116. 2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate
117. 2+
118. Inositol 1,4,5-trisphosphate affinity chromatography
119. Synthetic inositol 1,3,4,5-tetrakisphosphate analogues
120. Changes in cytoplasmic pH and membrane potential in thrombin-stimulated human platelets
121. 2+ mobilization in the apparent absence of inositol 1,4,5-trisphosphate 3-kinase activity
122. Inositol-1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate inhibit inositol-1,3,4,5-tetrakisphosphate 3-phosphatase in rat parotid gland
123. Calcium-dependent inositol trisphosphate-induced calcium release in the guinea-pig taenia caeci
124. 2+ dependence of inositol 1,4,5-trisphosphate-induced Ca release in smooth muscle cells of the guinea pig taenia caeci
125. 2+-transport ATPase
126. 2+ entry inositol phosphates—a possible mechanism
127. Inositol tetrakisphosphate as a second messenger confusions contradictions and a potential resolution
128. 2+
129. Inositol (1,3,4,5)-tetrakisphosphate-induced activation of sea-urchin eggs requires the presence of inositol trisphosphate
130. 3 3-kinase activity in animal tissues
131. 2+ mobilization from Swiss-mouse 3T3 cells
132. Inositol phosphates: proliferation, metabolism and function
133. Calcium oscillations in electrically non-excitable cells
134. Imaging cytoplasmic free calcium in histamine stimulated endothelial cells and in fMet-LeuPhe stimulated neutrophils
135. Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells
136. Calcium modulation of inositol 1,4,5-trisphosphate-induced calcium release from neuroblastoma × glioma hybrid (NG108-15) microsomes
137. Interactions between the effects of α- and β-adrenoceptor agonists and adenine nucleotides on the membrane potential of cells in guinea-pig liver slices
138. 2+-dependent ATPase of sarcoplasmic reticulum in rat skeletal muscle by immunoferritin labeling of ultrathin frozen sections
139. The relationship between inositol trisphosphate receptor density and calcium release in brain microsomes
140. 2+ transient
141. The effect of external calcium and pH on inositol trisphosphate-mediated calcium release from cerebellum microsomal fractions
142. 2+ pool
143. 2+ release from rat liver microsomes. Vesicle fusion is not required
144. 2+ channels
145. 2+ release in smooth muscle
146. Mammalian aldolases are isomer-selective high-affinity inositol polyphosphate binders
147. Sarcoplasmic reticulum proteins in phagocytes: biochemical, immunological and functional characterization
148. 2+ pumping sites in human neutrophils
149. 2+-handling by non-muscle cells: studies in human neutrophils and HL-60 cells
150. 2+ store in HL-60 cells
151. Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes
152. 2+ channel activity
153. Purification and reconstitution of the calcium release channel from skeletal muscle
154. 2+ channels in isolated red beet root vacuole membrane by inositol 1,4,5-trisphosphate
155. Spiral calcium wave propagation and annihilation in Xenopus laevis oocytes
156. 45calcium accumulation in permeable guinea-pig hepatocytes
157. Cyclic GMP and the mechanisms of vasolidation
158. 2+-ATPase gene
159. 2+
160. 400 protein, a glycoprotein characteristic of Purkinje cell, from mouse cerebellum
161. 3 receptor complex
162. Structural and functional characterization of inositol 1,4,5-trisphosphate receptor channel from mouse cerebellum
163. 2+ store
164. 32P]trisphosphate binding to isolated rat liver nuclei: Evidence for inositol trisphosphate receptor-mediated release release from the nucleus
165. Smooth muscle and brain inositol 1,4,5-trisphosphate receptors are structurally and functionally similar
166. Delay of the Ca mobilization response to muscarinic stimulation
167. Hormonal regulation of inositol 1,4,5-trisphosphate receptor in rat liver
168. 2+ release in sarcoplasmic reticulum
169. 2+ storage organelles in nonmuscle cells: heterogeneity and functional assignment
170. Rapid increases in cytosolic free calcium in response to muscarinic stimulation of rat parotid acinar cells
171. Regulation of cytosolic free calcium in fura-2-loaded rat parotid acinar cells
172. Cell signaling by second messenger waves
173. Molecular model for receptor-stimulated calcium spiking
174. Transient calcium release induced by successive increments of inositol 1,4,5-trisphosphate
175. Calcium spiking
176. Highly cooperative opening of calcium channels by inositol 1,4,5-trisphosphate
177. Kinetics of calcium channel opening by inositol 1,4,5-trisphosphate
178. Inositol phospholipids and cell surface receptor function
179. The ligand binding site and transduction mechanism in the inositol-1,4,5-trisphosphate receptor
180. Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor
181. Structure and expression of the rat inositol 1,4,5-trisphosphate receptor
182. Latencies of membrane currents evoked in Xenopus oocytes by receptor activation, inositol trisphosphate and calcium
183. 2+ stores in aortic smooth muscle cells of the rat
184. 2+-uptake mechanism
185. Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores
186. 2+ uptake by intracellular stores
187. 400, has calcium release activity in a fibroblast L cell line
188. + exchange and cytoplasmic pH in the action of growth factors in human fibroblasts
189. 2+ sequestration
190. 1-adrenergic responses in rat liver by a cAMP-dependent mechanism
191. Partial purification and some properties of rat brain inositol 1,4,5-trisphosphate 3-kinase
192. + channels
193. Purification and characterization of the inositol 1,4,5-trisphosphate receptor protein from rat vas deferens
194. G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides
195. Inositol trisphosphate modification of ions transport in rough endoplasmic reticulum
196. Hormone-evoked calcium release from intracellular stores is a quantal process
197. 2+ pool in pancreatic acini
198. Calcium entry into the inositol 1,4,5-trisphosphate-releasable calcium pool is mediated by a GTP-regulatory mechanism
199. Molecular recognition of inositol polyphosphates by intracellular receptors and metabolic enzymes
200. 2+ release
201. Conformations of Torpedo acetylcholine receptor associated with ion transport and desentization
202. 2+ pool in liver nuclei
203. cDNA cloning and characterization of three genes uniquely expressed in cerebellum by Purkinje neurons
204. The inositol 1,4,5-trisphosphate receptor and calcium mobilization
205. 2+-mobilizing receptors
206. Intraluminal calcium and inositol trisphosphate regulate calcium mobilization
207. Molecular target size of inositol 1,4,5-trisphosphate receptors in cerebellum and liver
208. 2+ in guinea-pig isolated hepatocytes
209. 2+ stores
210. 2+ mobilization stimulated by inositol 1,4,5-trisphosphate in permeabilized hepatocytes
211. The inositol 1,4,5-trisphosphate receptor binding sites of platelet membranes: pH-dependency, inhibition by polymeric sulphates, and the possible presence of arginine at the binding site
212. 2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum
213. 2+ release from intracellular membrane systems
214. + channel blockers
215. 3 in unstimulated and vasopressin-stimulated rat hepatocytes
216. 2+
217. Localized all-or-nothing calcium liberation by inositol trisphosphate
218. 2+ in Xenopus oocytes and facilitates responses to inositol trisphosphate
219. Caffeine inhibits inositol trisphosphate-mediated liberation of intracellular calcium in Xenopus oocytes
220. Nonlinearity and facilitation in phosphoinositide signaling studies by the use of caged inositol trisphosphate in Xenopus oocytes
221. The localization of calcium release by inositol trisphosphate in Limulus photoreceptors and its control by negative feedback
222. Feedback inhibition by calcium limits the release of calcium by inositol trisphosphate in Limulus ventral photoreceptors
223. Functional expression of the calcium release channel from skeletal muscle ryanodine receptor cDNA
224. Characterization of two forms of inositol 1,4,5-trisphosphate receptor in rat liver
225. Calcium mediates the interconversion between two states of the liver inositol 1,4,5-trisphosphate receptor
226. Structural and functional aspects of calcium homeostasis in eukaryotic cells
227. Mass changes in inositol tetrakis- and pentakisphosphate isomers induced by chemotactic peptide stimulation in HL-60 cells
228. Metabolism of synthetic inositol trisphosphate analogs
229. 2+ from rat insulinoma microsomes by inositol 1,4,5-trisphosphate
230. 2+-sequestering pools and the action of inositol 1,4,5-trisphosphate
231. 2+ cycle of a rat insulinoma cell line
232. Changes in inositol-1,4,5-trisphosphate binding to hepatic plasma membranes caused by temperature, N-ethylmaleimide and menadione
233. A model for receptor-regulated calcium entry
234. Capacitative calcium entry revisited
235. The control of transepithelial potential oscillations in the salivary gland of Calliphora erythrocephala
236. Frequency encoded biochemical regulation is more accurate than amplitude dependent control
237. Calcium messenger system: an integrated view
238. Odor stimuli trigger influx of calcium into olfactory neurons of the channel catfish
239. 2+ in lymphocytes
240. Inositol 1,4,5-trisphosphate and oxytocin binding in human myometrium
241. Organization of intracellular calcium signals generated by inositol lipid-dependent hormones
242. Agonist-induced cytosolic calcium oscillations originate from a specific locus in single hepatocytes
243. Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons
244. The inositol 1,4,5-trisphosphate-binding site in adrenal cortical cells is distinct from the endoplasmic reticulum
245. Subcellular distribution of the calcium-storing inositol 1,4,5-trisphosphate-sensitive organelle in rat liver
246. 2+-mobilising properties of fluoro-analogues of myo-inositol 1,4,5-trisphosphate and their interaction myo-inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase
247. 2+-releasing D-myoinositol 1,4,5-trisphosphate receptor, and the metabolic enzymes 5-phosphatase and 3-kinase
248. The kinetics of changes in intracellular calcium concentration in fura-2-loaded human platelets
249. Synchronized oscillations in cytoplasmic free calcium concentration in confluent bradykinin-stimulated bovine pulmonary artery endothelial cell monolayers
250. 2+ concentration in fura-2-loaded human neutrophils
251. Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide
252. The inositol 1,4,5-trisphosphate receptor in cerebellar Purkinje cells. Quantitative immunogold labeling reveals concentration in an endoplasmic reticulum subcompartment
253. Synthesis and application of photoaffinity analogues of inositol 1,4,5-trisphosphate selectively substituted at the 1-phosphate group
254. Study of a temperature-sensitive mutant of the ras-related YPT1 gene product ion yeast suggests a role in regulation in intracellular calcium
255. Frequency and amplitude enhancement of calcium transients by cyclic AMP in hepatocytes
256. 2+ pools
257. The formation of inositol 1,2-cyclic 4,5-trisphosphate and inositol 1,2-cyclic 4-bisphosphate on stimulation of mouse pancreatic minilobules with carbamylcholine
258. Potassium-channel blockers inhibit inositol trisphosphate-induced calcium release in the microsomal fractions isolated from the rat brain
259. Kinetic consequences of the inhibition by ATP of the metabolism of inositol (1,4,5)trisphosphate and inositol (1,3,4,5)tetrakisphosphate. Different effects upon the 3- and 5-phosphates
260. Regulation of the metabolism of 1,2-diacylglycerols and inositol phosphates that respond to receptor activation
261. Receptor-activated calcium entry in exocrine cells does not occur via agonist-sensitive intracellular pools
262. Temperature and nucleotide dependence of calcium release by myo-inositol 1,4,5-trisphosphate in cultured vascular smooth muscle cells
263. Cellular site of calcium regulation
264. Inositol trisphosphate, calcium and muscle contraction
265. 32P-inositol-1,4,5-trisphosphate in hepatocytes and neutrophils
266. myo-Inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate
267. 2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol 1,4,5-trisphosphate
268. Effect of inositol-1,4,5-trisphosphate on isolated subcellular fractions of rat pancreas
269. 2+ by inositol 1,4,5-trisphosphate. Comaparison with inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate
270. Decavanadate interacts with inositol polyphosphate binding sites and is a competitive antagonist of the inositol 1,4,5-trisphosphate receptor
271. Inositol (1,4,5)-triphosphate activates a calcium channel in isolated sarcoplasmic reticulum membranes
272. 2+ from saponin-permeabilized single cells of the porcine coronary artery
273. Cyclic AMP-dependent phosphorylation of brain inositol trisphosphate receptor decreases its release of calcium
274. Solubilization, purification and characterization of an inositol trisphosphate receptor
275. Thimerosal enhances calcium-induced calcium release in unfertilized hamster eggs
276. Activation of a low specific activity form of DNA polymerase α by inositol-1,4-bisphosphate
277. 2+/calmodulin-stimulated activity
278. Capacitative calcium entry in parotid acinar cells
279. 2+ fluxes at the plasma membrane
280. Inositol 1,4,5-trisphosphate and inositol 1,2-cyclic 4,5-trisphosphate are minor components of total mass of inositol trisphosphate in th thrombin-stimulated platelets
281. 1 cells induced by thyrotropin-releasing hormone
282. 2+ entry. Secret pathway or secret messenger
283. 2+ stores depends on inositol 1,4,5-trisphosphate concentration
284. Size of the inositol 1,4,5-trisphosphate-sensitive calcium pool in guinea-pig hepatocytes
285. Inositol 1,4,5-trisphosphorothioate, a stable analogue of inositol trisphosphate which mobilizes intracellular calcium
286. Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage
287. 2+-ATPase
288. Regulation of calcium homeostasis in sensory neurones by bradykinin
289. Solubilization and separation of inositol 1,3,4,5-tetrakisphosphate- and inositol 1,4,5-trisphosphate-binding proteins and metabolizing enzymes in rat brain
290. Demonstration of inositol 1,3,4,5-tetrakisphosphate receptor binding
291. Inositol 1,3,4,5-tetrakisphosphate and inositol hexakisphosphate receptor proteins: Isolation and characterization from rat brain
292. +-ion dependent calcium uptake into an inositol 1,4,5-trisphosphate-sensitive calcium pool from rat parotid gland
293. 2+ pools in rat pancreatic acinar cells
294. 2+ pool by GTP in permeabilized hepatocytes
295. The effect of heparin on the inositol 1,4,5-trisphosphate receptor in rat liver microsomes
296. 2+
297. 2+-storage compartments (calciosomes) of liver and brain
298. Fluorescent probes of cell signalling
299. 2+ by sarcoplasmic reticulum in vascular smooth muscle
300. Influence of inositol 1,4,5-trisphosphate and guanine nucleotides on intracellular calcium release within the NIE-115 neuronal cell line
301. Proton gating of calcium release channels in vesicles derived from junctional sarcoplasmic reticulum
302. Are there subtypes of the inositol 1,4,5-trisphosphate receptor?
303. 2+ channels from brain microsomal membranes reconstituted in patch-clamped bilayers
304. Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle
305. Inositol trisphosphate and thapsigargin discriminate endoplasmic reticulum stores of calcium in rat brain
306. 2+ ATPase and of the ER lumenal protein, Bip.
307. Opening of dihydropyridine calcium channels in skeletal muscle membranes by inositol trisphosphate
308. 2+ release. II Effect of cAMP-dependent protein kinase
309. Inositol 1,4,5-trisphosphate induces a calcium release from sarcoplasmic reticulum of skeletal muscle
310. 2+ store of nonmuscle cells?
311. Phosphoinositide metabolism and excitation-contraction coupling in smooth, cardiac and skeletal muscle
312. 2+
313. Three-dimensional architecture of the calcium channel/foot structure of sarcoplasmic reticulum
314. Calcium uptake into acini from rat pancreas: evidence for intracellular ATP-dependent calcium sequestration
315. Pulsatile intracellular calcium release does not depend on fluctuations in inositol trisphosphate concentration
316. r 260,000
317. Kinetics of smooth muscle and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate
318. Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system
319. Ryanodine and inositol trisphosphate receptors coexist in avian cerebellar Purkinje neurons
320. Inositol 1,4,5-trisphosphate stimulates phosphorylation of a 62,000-dalton protein in monkey fibroblast and bovine brain cell lysates
321. 3H]inositol 1,4,5-trisphosphate to its receptor
322. 3H]inositol 1,4,5-trisphosphate in particulate preparations of rat cerebellum
323. Inositol 1:2-cyclic,4,5-trisphosphate is only a weak agonist at inositol 1,4,5-trisphosphate receptors
324. Characteristics of inositol 1,4,5-trisphosphate binding to rat cerebellar and bovine cortical membranes: evidence for the heterogeneity of binding sites
325. 2+ release in permeabilized pancreatic acinar cells
326. Second messenger role for inositol trisphosphate for mobilization of intracellular calcium in liver
327. Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes
328. Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes
329. 2+
330. Purification and characterization of inositol 1,4,5-trisphosphate 3-kinase from pig aortic smooth muscle
331. Inositol-1,4,5-trisphosphate releases calcium from skinned cultured smooth muscle cells
332. 2+ release from skinned rat aortic smooth muscle cells in primary culture
333. 2+ release from skinned and cultured smooth muscle cells
334. 3H inositol trisphosphate binding to dog cerebellar membranes
335. 2+ release from bovine adrenal medullary secretory vesicles
336. 2+ in cells from peripheral tissues
337. 2+ release in permeabilized UMR-106-01 cells
338. 2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum