The role of free radicals in airway obstruction in asthmatic patients

Chest

Volumn 100, Issue 5, 1991, Pages 1319-1322

  Kanazawa, H ^a   Kurihara, N ^a   Hirata, K ^a   Takeda, T ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CYTOCHROME C; FORMYLMETHIONYLLEUCYLPHENYLALANINE; FREE RADICAL; METHACHOLINE; PHORBOL 13 ACETATE 12 MYRISTATE; SUPEROXIDE; SUPEROXIDE DISMUTASE; THEOPHYLLINE;

ADULT; AGED; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN CELL; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION TEST; MALE; NEUTROPHIL; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0025939165     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.100.5.1319     Document Type: Article

References (22)

1. Juniper ET Firth PA Hargreave FE. Airway responsiveness to histamine and methacholine: relationship to minimum treatment control symptoms of asthma. Thorax 36 1981 575 579
2. Chung KF. Role of inflammation in the hyperreactivity of the airways in asthma. Thorax 41 1986 657 662
3. Metzger WJ Richerson HB Worden K Monick M Hunninghake GW. Bronchoalveolar lavage of allergic patients following allergen bronchoprovocation. Chest 89 1986 477 483
4. Metzger WJ Zavala D Richerson HB. Local allergen challenge and bronchoalveolar lavage of allergic asthmatic lungs. Am Rev Respir Dis 135 1987 433 440
5. Gin W Kay AB. The effect of corticosteroids on monocyte and neutrophil activation in bronchial asthma. J Allergy Clin Immunol 76 1985 675 682
6. Gin W Shaw RJ Kay AB. Airways reversibility after predonisolone therapy in chronic asthma is associated with alteration in leukocyte function. Am Rev Respir Dis 132 1985 1199 1203
7. Arm JP Walport JJ Loe TH. Expression of complement receptors type 1 (CR1) and type 3 (CR3) on circulating granulocytes in experimentally provoked asthma. J Allergy Clin Immunol 83 1989 649 655
8. Wang SR Yang CM Wang SSM Han SH Chiang BN. Enhancement of A 23187-induced production of the slow-reacting substance on peripheral leukocytes from subjects with asthma. J Allergy Clin Immunol 77 1986 465 471
9. Mita H Yui Y Taniguchi N Yasuda H Shida T. Increased activity of 5-lipooxygenase in polymorphonuclear leukocytes from asthmatic patients. Life Sci 37 1985 907 914
10. Borgeat P Samuelsson B. Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophone A 23187. Proc Natl Acad Sci USA 76 1979 2148 2152
11. Goldstein IM Malmsten CL Samuelsson B Weissman G. Prostaglandins, thromboxanes, and polymorphonuclear leukocytes. Inflammation 2 1977 309 317
12. Babior BM. Oxygen-dependent microbial killing by phagocytes. N Engl J Med 298 1978 721 725
13. Petrone WF English DK Wong K McCord JM. Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma. 1980 Proc Natl Acad Sci USA 1159 1163
14. Boyum A. Isolation of mononuclear cells and granulocytes from human blood: isolation of mononuclear cells by one centrifugation and of granulocytes by combining centrifugation and sedimentation at 1g. Scand J Clin Lab Invest 21 suppl 97 1968 77 89
15. McCord JM Fredorich I. Superoxide dismutase. J Biol Chem 224 1969 6049 6055
16. Massey V. The microestimation of succinate and the extinction coefficient of cytochrome C. Biochem Biophys Acta 34 1969 225 256
17. Marone G Thomas LL Lichtenstein LM. The role of agonists that active adenylate cyclase in the control of cAHP metabolism and enzyme release by human polymorphonuclear leukocytes. J Immunol 125 1980 2277 2283
18. Neijens HJ Raateep RE Degenhart J Duiverman EJ Kerrebijn KF. Altered leukocyte response in relation to the basic abnormality in children with asthma and bronchial hyperresponsiveness. Am Rev Respir Dis 130 1984 744 747
19. O'Byrne PM Walters EH Gold BD. Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure. Am Rev Respir Dis 130 1984 214 219
20. Holtzman MJ Fabbri LM O'Byrne PM Gold BD Aizawa H Walters EH Importance of airway inflammation for hyperresponsiveness induced by ozone. Am Rev Respir Dis 127 1983 686 690
21. Seltzer J Bigby BG Stulbarg M. Ozone-induced change in bronchial reactivity to methacholine and airway inflammation in humans. J Appl Physiol 60 1986 1321
22. Shasby DM Vandenthuysen KM Tate RM Shasby SS McMurtry I Repine JE. Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with PMA: role of oxygen radicals. Am Rev Respir Dis 125 1982 443 447