Stereoselective Disposition of Etodolac Enantiomers in Synovial Fluid

The Journal of Clinical Pharmacology

Volumn 31, Issue 8, 1991, Pages 741-746

  Brocks, Dion R ^a   Jamali, Fakhreddin ^a   Russell, Anthony S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ETODOLAC; ETODOLAC DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; AGED; CLINICAL ARTICLE; CONFERENCE PAPER; DRUG DISPOSITION; DRUG PROTEIN BINDING; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; RHEUMATOID ARTHRITIS; STEREOSPECIFICITY; SYNOVIAL FLUID;

AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS; BLOOD PROTEINS; COMPARATIVE STUDY; ETODOLAC; FEMALE; HUMAN; HYALURONIC ACID; INDOLEACETIC ACIDS; MALE; MIDDLE AGE; PROTEIN BINDING; STEREOISOMERISM; SUPPORT, NON-U.S. GOV'T; SYNOVIAL FLUID;

EID: 0025938240     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1991.tb03770.x     Document Type: Article

References (18)

1. Antirheumatic drug concentrations in human synovial fluid and synovial tissue: Observations on extravascular pharmacokinetics
2. Minimum effective dose of etodolac for the treatment of rheumatoid arthritis
3. Evaluation of the efficacy and comparative effects on gastric and duodenal mucosa of etodolac and naproxen in patients with rheumatoid arthritis using endoscopy
4. Stereoselective gas chromatographic analysis of etodolac enantiomers in human plasma and urine
5. Application of a stereospecific high‐performance liquid chromatography assay to a pharmacokinetic study of etodolac enantiomers in humans
6. The pharmacokinetics of etodolac in serum and synovial fluid of patients with arthritis
7. Etodolac (1,8‐diethyl‐1,3,4,9‐tetrahydropyrano[3,4‐b]indole‐1‐acetic acid): A potent anti‐inflammatory drug. Conformation and absolute configuration of its active enantiomer
8. Protein measurement with the Folin phenol reagent
9. Synovial fluid
10. Total and free ketoprofen in serum and synovial fluid after intramuscular injection
11. Synovial and serum levels of methotrexate during methotrexate therapy of rheumatoid arthritis
12. Design and optimization of dosage regimens; pharmacokinetic data
13. Entero‐hepatic cycling of methotrexate estimated by use of the D‐isomer as a reference marker
14. Plasma and synovial fluid meclofenamic acid concentrations in patients with rheumatoid arthritis of the knee
15. Performance of a diffusional clearance model for β‐lactam antimicrobial agents as influenced by extravascular protein binding and interstitial fluid kinetics
16. Synovial fluid glycosidase activity
17. Plasma and synovial fluid concentrations of diclofenac sodium and its hydroxylated metabolites during once‐daily administration of a 100 mg formulation