Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization

Molecular Endocrinology

Volumn 5, Issue 10, 1991, Pages 1396-1404

  Jenster, Guido ^a   Van Der Korput, Hetty A G M ^a   Vroonhoven, Cor Van ^a   Van Der Kwast, Theo H ^a   Trapman, Jan ^a   Brinkmann, Albert O ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; STEROID BINDING; TRANSCRIPTION REGULATION;

ANIMAL; BINDING SITES; CELL LINE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CHROMOSOME DELETION; DNA-BINDING PROTEINS; GENETIC VECTORS; HELA CELLS; HUMAN; IMMUNOHISTOCHEMISTRY; METRIBOLONE; PLASMIDS; RECEPTORS, ANDROGEN; RECOMBINANT PROTEINS; RESTRICTION MAPPING; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0025935923     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/mend-5-10-1396     Document Type: Article

References (51)

1. Green S, Chambon P 1988 Nuclear receptors enhance our understanding of transcription regulation. Trends Gen 4:309-314
2. Evans RM 1988 The steroid and thyroid hormone receptor superfamily. Science 240:889-895
3. Kumar V, Green S, Stack G, Berry M, Jin J-R, Chambon P 1987 Functional domains of the human estrogen receptor. Cell 51:941-951
4. Giguere V, Hollenberg SM, Rosenfeld MG, Evans RM 1986 Functional domains of the human glucocorticoid receptor. Cell 46:645-652
5. Dobson ADW, Conneely OM, Beattie W, Maxwell BL, Mak P, Tsai M-J, Schrader WT, O’Malley BW 1989 Mutational analysis of the chicken progesterone receptor. J Biol Chem 264:4207-4211
6. Gronemeyer H, Turcotte B, Quirin-Stricker C, Bocquel MT, Meyer ME, Krozowski Z, Jeltsch JM, Lerouge T, Gamier JM, Chambon P 1987 The chicken progesterone receptor: sequence, expression and functional analysis. EMBO J 6:3985-3994
7. Pratt WB, Sanchez ER, Bresnick EH, Meshinchi S, Scher-rer LC, Dalman FC, Welsh MJ 1989 Interaction of the glucocorticoid receptor with the M 90000 heat shock protein: an evolving model of ligand-mediated receptor transformation and translocation. Cancer Res 49:2222s-2229s
8. Howard KJ, Holley SJ, Yamamoto KR, Distelhorst CW1990 Mapping the hsp 90 binding region of the glucocorticoid receptor. J Biol Chem 265:11928-11935
9. Kost SL, Smith DF, Sullivan WP, Welch WJ, Toft DO 1989 Binding of heat shock proteins to the avian progesterone receptor. Mol Cell Biol 9:3829-3838
10. Pratt WB 1990 Interaction of hsp90 with steroid receptors: organizing some diverse observations and presenting the newest concept. Mol Cell Endocrinol 74:c69-c76
11. Tsai SY, Carlstedt-Duke J, Weigel NL, Dahlman K, Gustafsson J-A, Tsai MJ, O’Malley BW 1988 Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation. Cell 55:361-369
12. Fawell SE, Lees JA, White R, Parker MG 1990 Characterization and colocalization of steroid binding and dimerisation activities in the mouse estrogen receptor. Cell60:953-962
13. Guiochon-Mantel A, Loosfelt H, Lescop P, Sar S, Atger M, Perrot-Applanat M, Milgrom E 1989 Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers. Cell 57:1147-1154
14. Picard D, Yamamoto KR 1987 Two signals mediate hormone- dependent nuclear localization of the glucocorticoid receptor. EMBO J 6:3333-3340
15. Ris-Stalpers C, Kuiper GGJ M, Faber PW, Schweikert HU, van Rooij HCJ, Zegers ND, Hodgins MB, Degenhart HJ, Trapman J, Brinkmann AO 1990 Aberrant splicing of androgen receptor mRNA results in synthesis of a nonfunctional receptor protein in a patient with androgen insensitivity. Proc Natl Acad Sci USA 87:7866-7870
16. Sai T, Seino S, Chang C, Trifiro M, Pinsky L, Mhatre A, Kaufman M, Lambert B, Trapman J, Brinkmann AO, Rosenfield RL, Liao S 1990 An exonic point mutation of the androgen receptor gene in a family with complete androgen insensitivity. Am J Hum Genet 46:1095-1100
17. Marcelli M, Tilley WD, Wilson CM, Wilson JD, Griffin JE, McPhaul MJ 1990 A single nucleotide substitution introduces a premature termination codon into the androgen receptor gene of a patient with receptor-negative androgen resistance. J Clin Invest 85:1522-1528
18. Lubahn DB, Brown TR, Simental JA, Higgs HN, Migeon CJ, Wilson EM, French FS 1989 Sequence of the intron/ exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity. Proc Natl Acad Sci USA 86:9534-9538
19. Brown TR, Lubahn DB, Wilson EM, French FS, Migeon CJ, Corden JL 1990 Functional characterization of naturally occurring mutant androgen receptors from subjects with complete androgen insensitivity. Mol Endocrinol4:1759-1772
20. Perrot-Applanat M, Logeat F, Groyer-Picard MT, Milgrom E 1985 Immunocytochemical study of mammalian progesterone receptor using monoclonal antibodies. Endocrinology 116:1473-1483
21. King WJ, Greene GL 1984 Monoclonal antibodies localize estrogen receptor in the nuclei of target cells. Nature 307:745-749
22. Fuxe K, Wikström A-C, Okret S, Agnati LF, Härfstrand A, Yu Z-Y, Granholm L, Zoli M, Vale W, Gustafsson J-A 1985 Mapping the glucocorticoid receptor immunoreac-tive neurons in the rat tel- and diencephalon using monoclonal antibody against rat liver glucocorticoid receptor. Endocrinology 117:1803-1812
23. Wikström A-C, Bakke O, Okret S, Bronnegard M, Gustafsson J-A 1987 Intracellular localization of the glucocorticoid receptor: evidence for cytoplasmic and nuclear localization. Endocrinology 120:1232-1242
24. Husmann DA, Wilson CM, McPhaul MJ, Tilley WD, Wilson JD 1990 Antipeptide antibodies to two distinct regions of the androgen receptor localize the receptor protein to the nuclei of target cells in the rat and human prostate. Endocrinology 126:2359-2368
25. Sar M, Lubahn DB, French FS, Wilson EM 1990 Immu-nohlstochemical localization of the androgen receptor in rat and human tissues. Endocrinology 127:3180-3186
26. vander Kwast Th H, Schalken J, Ruizeveld de Winter JA, van Vroonhoven CCJ, Mulder E, Boersma W, Trapman J 1991 Androgen receptors in endocrine-therapy-resistant human prostate cancer. Int J Cancer 48:189-193
27. Simental JA, Sar M, Lane MV, French FS, Wilson EM 1991 Transcriptional activation and nuclear targeting signals of the human androgen receptor. J Biol Chem 266:510-518
28. Brinkmann AO, Faber PW, van Rooij HCJ, Kuiper GGJM, Ris C, Klaassen P, van der Korput JAGM, Voorhorst MM, van Laar JH, Mulder E, Trapman J 1989 The human androgen receptor: domain structure, genomic organization and regulation of expression. J Steroid Biochem34:307-310
29. Zegers ND, Claassen E, Neelen C, Mulder E, van Laar JH, Voorhorst MM, Berrevoets CA, Brinkmann AO, vander Kwast Th H, de Winter JAR, Trapman J, Boersma WJA 1991 Epitope prediction and confirmation for the human androgen receptor: generation of monoclonal antibodies for multi-assay performance following the synthetic peptide strategy. Biochim Biophys Acta 1073:2332
30. van Laar JH, Voorhorst-Ogink MM, Zegers ND, Boersma WJA, Claassen E, van der Korput JAGM, Ruizeveld de Winter JA, vander Kwast Th H, Mulder E, Trapman J, Brinkmann AO 1989 Characterization of polyclonal antibodies against the N-terminal domain of the human androgen receptor. Mol Cell Endocrinol 67:29-38
31. Schüle R, Muller M, Kaltschmidt C, Renkawitz R 1988Many transcription factors interact synergistically with steroid receptors. Science 242:1418-1420
32. Kuiper GGJM, de Ruiter PE, Grootegoed JA, Brinkmann AO, Synthesis and post-translational modification of the androgen receptor in LNCa P cells. Mol Cell Endocrinol, in press
33. Sheridan PL, Francis MD, Horwitz KB 1989 Synthesis of human progesterone receptors in T47D cells. J Biol Chem264:7054-7058
34. Faber PW, Kuiper GGJ M, van Rooij HCJ, van der Korput JAG M, Brinkmann AO, Trapman J 1989 The N-terminal domain of the human androgen receptor is encoded by one large exon. Mol Cell Endocrinol 61:257-262
35. Denner LA, Schrader WT, O’Malley BW, Weigel NL 1990Hormonal regulation and identification of chicken progesterone receptor phosphorylation sites. J Biol Chem265:16548-16555
36. Simons SS, Sistare FD, Chakraborti PK 1989 Steroid binding activity is retained in a 16 kDa fragment of the steroid binding domain of rat glucocorticoid receptors. J Biol Chem 264:14493-14497
37. Lees JA, Fawell SE, Parker MG 1989 Identification of two transactivation domains in the mouse oestrogen receptor. Nucleic Acids Res 17:5477-5488
38. Rundlett SE, Wu X-P, Miesfeld RL 1990 Functional characterizations of the androgen receptor confirm that the molecular basis for androgen action is transcription regulation. Mol Endocrinol 4:708-714
39. Marcelli M, Tilley WD, Wilson CM, Griffin JE, Wilson JD, McPhaul MJ 1990 Definition of the human androgen receptor gene structure permits the identification of mutants that cause androgen resistance: premature termination of the receptor protein at amino acid residue 588 causes complete androgen resistance. Mol Endocrinol 4:1105-1116
40. Godowski PJ, Rusconi S, Miesfeld R, Yamamoto KR 1987Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. Nature 325:365-368
41. Miesfeld R, Godowski PJ, Maler BA, Yamamoto KR 1987Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation. Science 236:423-427
42. Hollenberg SM, Evans RM 1988 Multiple and cooperative trans- activation domains of the human glucocorticoid receptor. Cell 55:899-906
43. Danielsen M, Northrop JP, Jonklaas J, Ringold GM 1987Domains of the glucocorticoid receptor involved in specific and nonspecific DNA binding, hormone activation and transcriptional enhancement. Mol Endocrinol 1:816-821
44. Hollenberg SM, Giguere V, Segui P, Evans RM 1987Colocalization of DNA binding and transcriptional activation functions in the human glucocorticoid receptor. Cell49:39-46
45. Ptashne M 1988 How eukaryotic transcriptional activators work. Nature 335:683-689
46. Haynes SR, Rebbert ML, Mozer BA, Forquignon F, Dawid IB 1987 Pen repeat sequences are GGN clusters and encode a glycine-rich domain in a Drosophila cDNA homologous to the rat helix destabilizing protein. Proc Natl Acad Sci USA 84:1819-1823
47. 2 encodes a homeobox. Cell 53:339-340
48. Peterson MG, Tanese N, Pugh BF, Tjian R 1990 Functional domains and upstream activation properties of cloned human TATA binding protein. Science 248:1625-1630
49. Chen C, Okayama H 1987 High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752
50. Mulder E, Vrij L, Foekens JA 1981 Extraction of nuclear androgen receptors from rat prostate with different reagents. Mol Cell Endocrinol 23:283-296
51. Seed B, Sheen J-Y 1988 A simple phase-extraction assay for chloramphenicol acetyltransferase activity. Gene 67:271-277