Structure-Activity Studies of Antitumor Agents Based on Pyrrolo[1,2-a]benzimidazoles: New Reductive Alkylating DNA Cleaving Agents

Journal of Medicinal Chemistry

Volumn 34, Issue 10, 1991, Pages 2954-2961

  Islam, Imadul ^a   Skibo, Edward B ^a   Dorr, Robert T ^b   Alberts, David S ^b  

^a ARIZONA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ACETOXY 6 (1 AZIRIDINYL) 2,3 DIHYDRO 7 METHYL 1H PYRROLO[1,2 A]BENZIMIDAZOLE 5,8 DIONE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; DOXORUBICIN; MITOMYCIN C; PYRROLO[1,2 A]BENZIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARDIOTOXICITY; CROSS RESISTANCE; DNA CROSS LINKING; DNA STRAND BREAKAGE; FEMALE; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA P 388; MOUSE; MYELOMA CELL; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ALKYLATION; ANTINEOPLASTIC AGENTS; AZIRIDINES; BENZIMIDAZOLES; COLONIC NEOPLASMS; DNA; FEMALE; FREE RADICALS; HUMAN; MOLECULAR STRUCTURE; MULTIPLE MYELOMA; OVARIAN NEOPLASMS; OXIDATION-REDUCTION; OXYGEN; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0025931154     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00114a003     Document Type: Article

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